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GlossaryDerminator 2

The Derminator 2 is a microneedling device designed to promote hair growth and improve scalp health by creating micro-injuries in the skin. This process stimulates the body's natural healing response, which can enhance blood circulation and increase the absorption of topical treatments for hair loss. Its relevance to hair biology lies in its ability to potentially activate dormant hair follicles and improve the overall condition of the scalp, making it a popular choice among individuals seeking non-invasive hair restoration methods. Key distinguishing characteristics include its adjustable needle depth and speed settings, allowing for personalized treatment based on individual needs.

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research The Rotterdam Study: 2016 objectives and design update

336 citations , August 2015 in “European Journal of Epidemiology”

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

research The Epidemiology of Hospital-Treated Alopecia Areata in Denmark, 1995–2016

April 2024 in “Dermatology and therapy”

In Denmark from 1995 to 2016, hospital-treated alopecia areata cases increased, mostly affecting women and those over 50.

research Prostate Cancer Early Detection, Version 2.2015

67 citations , December 2015 in “Journal of the National Comprehensive Cancer Network”

The guidelines aim to find treatable prostate cancer early while avoiding unnecessary tests and treatments.

research Bibliometric evaluation of Anais Brasileiros de Dermatologia (2013-2022)

9 citations , September 2023 in “Anais Brasileiros de Dermatologia”

The journal Anais Brasileiros de Dermatologia has grown significantly in influence and visibility over the past decade.

research Clinical and Molecular Diagnostic Criteria of Congenital Atrichia with Papular Lesions11This paper originally appeared in issue 117:1662–1665, 2001. Following publication the authors indicated that important corrections at page proof were not taken in. To ensure that the paper is published as intended, the editors have decided to reproduce the contents in full.

69 citations , May 2002 in “Journal of Investigative Dermatology”

Congenital atrichia with papular lesions is often misdiagnosed, and new diagnostic criteria can improve accuracy.

research Global sex disparities in lifetime risk of alopecia areata: a systematic analysis from the global burden of disease study, 1990 to 2021

September 2025 in “Biology of Sex Differences”

Females have a higher lifetime risk of alopecia areata than males.

Association of Gly972Arg Variant of Insulin Receptor Substrate-1 and Gly1057Asp Variant of Insulin Receptor Substrate-2 with Polycystic Ovary Syndrome in the Chinese Population

research Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population

10 citations , October 2014 in “Journal of Ovarian Research”

The IRS-2 Asp/Asp genotype may increase the risk of PCOS in Chinese women, especially if they are not obese.

Efficacy, Safety, and Dose Response of STS01, a Topical Controlled Release Nanoparticle Formulation (Dithranol/Prosilic), in Adults with Mild to Moderate Patchy Alopecia Areata: A Randomized, Double-Blind, Multicenter, Phase 2 Trial

research Efficacy, safety and dose response of STS01, a topical controlled release nanoparticle formulation (dithranol/Prosilic), in adults with mild to moderate patchy alopecia areata: A randomised, double-blind, multicentre, phase 2 trial

April 2026 in “medRxiv”

STS01 1% effectively promotes hair regrowth with minimal side effects.

Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program

research Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program

January 2024 in “American journal of clinical dermatology”

Ritlecitinib is safe and well-tolerated for treating alopecia areata in patients aged 12 and older.

research Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids

36 citations , August 2021 in “Nature Cell Biology”

Organoids can help study COVID-19 and develop treatments, but face challenges like instability and limited renewal.

Patched-Associated Tumors: Modifier Genes and Pathogenesis

research Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese

February 2022

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

research Finding Long-COVID: Temporal Topic Modeling of Electronic Health Records from the N3C and RECOVER Programs

September 2023 in “medRxiv (Cold Spring Harbor Laboratory)”

Long-COVID has diverse, long-term health impacts, especially in young people.

Cicatricial (Scarring) Alopecia: Clinical Presentations, Etiologies, and Histopathologic Features

research Cicatricial (scarring) alopecia

13 citations , April 2001 in “International Journal of Dermatology”

Different types of scarring alopecia may be stages of one disease, and accurate diagnosis is crucial to prevent permanent hair loss.

research The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report

1540 citations , October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

research Overweight and Obesity in Children and Adolescents

356 citations , September 2014 in “Journal of Clinical Research in Pediatric Endocrinology”

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

Skin Aging and Menopause: Implications for Treatment

research Skin Aging and Menopause

180 citations , January 2003 in “American Journal of Clinical Dermatology”

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Aging of hair

99 citations , June 2005 in “Journal of Cosmetic Dermatology”

Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.

Elucidating the Roles of Three β-Glucuronosyltransferases Acting on Arabinogalactan-Proteins Using a CRISPR-Cas9 Multiplexing Approach in Arabidopsis

research Elucidating the roles of three β-glucuronosyltransferases (GLCATs) acting on arabinogalactan-proteins using a CRISPR-Cas9 multiplexing approach in Arabidopsis

28 citations , May 2020 in “BMC plant biology”

The study concluded that three enzymes are important for plant development by affecting sugar composition and calcium binding in plants.

research Trichoscopy of Alopecia Areata: Hair Loss Feature Extraction and Computation Using Grid Line Selection and Eigenvalue

10 citations , September 2020 in “Computational and Mathematical Methods in Medicine”

Researchers developed an algorithm for self-diagnosing scalp conditions with high accuracy using smart device-attached microscopes.

Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium

research Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium

10 citations , May 2020 in “Dermatology Research and Practice”

Proteoglycans are important for hair growth, and a specific treatment can help reduce hair loss.

Methodology and Challenges to Recruitment to a Randomized, Double-Blind, Placebo-Controlled Trial of Oral DHEA in Postmenopausal Women

research Methodology and Challenges to Recruitment to a Randomized, Double-Blind, Placebo-Controlled Trial of Oral DHEA in Postmenopausal Women

9 citations , November 2008 in “Journal of Womens Health”

Researchers had trouble finding enough participants for a trial on DHEA's effects on postmenopausal women's sexual desire.

research A new locus for hereditary hypotrichosis simplex maps to chromosome 13q12.12∼12.3 in a Chinese family

7 citations , May 2010 in “Journal of Cutaneous Pathology”

A new genetic area linked to a rare hair loss condition was found on chromosome 13 in a Chinese family.

research HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth

6 citations , January 2020 in “Skin Pharmacology and Physiology”

HIF-1α stimulators, like deferiprone, work as well as popular hair loss treatments, minoxidil and caffeine, in promoting hair growth.

Detection of a Novel Missense Mutation in Atrichia with Papular Lesions

research Detection of a Novel Missense Mutations in Atrichia with Papular Lesions

4 citations , January 2011 in “Annals of Dermatology”

Researchers found a new mutation in the HR gene linked to a rare hair loss condition.

research A novel homozygous variant in the dsp gene underlies the first case of non-syndromic form of alopecia

2 citations , July 2015 in “Archives of Dermatological Research”

A new gene variant in the DSP gene is linked to a unique type of hair loss.

research Acne-Associated Syndromes

January 2019 in “Springer eBooks”

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

research Further Aspects of Hair Transplantation

November 2018 in “Springer eBooks”

The document concludes that hair transplant clinics should focus on effective marketing, online presence, and quality patient care, while the industry should promote high standards and education through organizations like FUE Europe.

research Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats

40 citations , December 2016 in “Journal of Ovarian Research”

Rutin may help treat symptoms of polycystic ovary syndrome (PCOS) in rats.

research Restorative effect of hair follicular dermal cells on injured human hair follicles in a mouse model

4 citations , January 2015 in “Experimental Dermatology”

Human hair follicle dermal cells can help repair damaged hair follicles.