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GlossaryDerminator 2

The Derminator 2 is a microneedling device designed to promote hair growth and improve scalp health by creating micro-injuries in the skin. This process stimulates the body's natural healing response, which can enhance blood circulation and increase the absorption of topical treatments for hair loss. Its relevance to hair biology lies in its ability to potentially activate dormant hair follicles and improve the overall condition of the scalp, making it a popular choice among individuals seeking non-invasive hair restoration methods. Key distinguishing characteristics include its adjustable needle depth and speed settings, allowing for personalized treatment based on individual needs.

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The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain

70 citations , December 2004 in “Differentiation”

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

research Characterization of a 300 kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain

77 citations , March 2000 in “Journal of Investigative Dermatology”

The research identified six functional hair keratin genes and four pseudogenes, providing insights into hair formation and gene organization.

research A Variable Monilethrix Phenotype Associated With a Novel Mutation, Glu402Lys, in the Helix Termination Motif of the Type II Hair Keratin hHb1

47 citations , July 1998 in “Journal of Investigative Dermatology”

A new mutation, Glu402Lys, in hair keratin is linked to variable symptoms of monilethrix.

research Monilethrix: A Novel Mutation (Glu402Lys) in the Helix Termination Motif and the First Causative Mutation (Asn114Asp) in the Helix Initiation Motif of the Type II Hair Keratin hHb6

29 citations , August 1999 in “Journal of Investigative Dermatology”

New mutations in hair keratin genes cause the rare hair disorder monilethrix.

research Two Different Mutations in the Same Codon of a Type II Hair Keratin (hHb6) in Patients with Monilethrix

20 citations , December 1999 in “Journal of Investigative Dermatology”

Mutations in the hHb6 gene cause the hair disorder monilethrix.

research Adrenal Cortex Tumors and Hyperplasias

2 citations , November 2011 in “InTech eBooks”

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

Reporting in Clinical Studies on Platelet-Rich Plasma Therapy Among All Medical Specialties: A Systematic Review of Level I and II Studies

research Reporting in clinical studies on platelet-rich plasma therapy among all medical specialties: A systematic review of Level I and II studies

18 citations , April 2021 in “PLOS ONE”

The review concluded that reporting on PRP therapy is often incomplete, leading to uncertainty about its effectiveness.

research PTCH1 Germline Mutations and the Basaloid Follicular Hamartoma Values in the Tumor Spectrum of Basal Cell Carcinoma Syndrome (NBCCS)

21 citations , January 2018 in “Anticancer Research”

NBCCS and BFHS might be the same syndrome, helping better identify and manage cases.

research NUDT15,FTO, andRUNX1genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases

40 citations , January 2017 in “Intestinal Research”

Genotyping for NUDT15 p.Arg139Cys can help predict thiopurine side effects in Japanese IBD patients.

research Trichoblastoma with sebaceous and sweat gland differentiation

12 citations , May 2001 in “British journal of dermatology/British journal of dermatology, Supplement”

A rare benign skin tumor showed unusual features of sebaceous and sweat glands, important for correct diagnosis.

research Fluridil, a Rationally Designed Topical Agent for Androgenetic Alopecia

August 2002 in “Dermatologic Surgery”

Fluridil safely promotes hair growth in men with androgenetic alopecia.

research Genetic Variation at the MC1R Locus and the Time since Loss of Human Body Hair

152 citations , January 2004 in “Current anthropology”

Humans lost body hair relatively recently in evolution.

research The logic of follicular unit transplantation

77 citations , April 1999 in “Dermatologic Clinics”

The document concludes that follicular unit transplantation offers more natural results and better graft survival than older hair transplant methods.

Frontal Fibrosing Alopecia: Reflections and Hypotheses on Etiology and Pathogenesis

research Frontal fibrosing alopecia: reflections and hypotheses on aetiology and pathogenesis

68 citations , May 2016 in “Experimental dermatology”

FFA's causes may include environmental triggers and genetic factors.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert.

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

Quantification of Reproductive Hormones in Hair of Captive Adult Brown Bears and Their Application as Indicators of Sex and Reproductive State

research The quantification of reproductive hormones in the hair of captive adult brown bears and their application as indicators of sex and reproductive state

33 citations , January 2017 in “Conservation physiology”

Measuring reproductive hormones in brown bear hair could help identify their sex and reproductive state, but better collection methods or lab techniques are needed.

research Psychotropic Medication and Drug-Related Alopecia

30 citations , May 1991 in “Psychosomatics”

Some psychiatric medications can cause reversible hair loss.

research KERATINS AND SKIN DISORDERS

28 citations , April 1996 in “Cell biology international”

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

The VEGF +405 G>C 5' Untranslated Region Polymorphism and Risk of PCOS: A Study in South Indian Women

research The VEGF +405 G>C 5' untranslated region polymorphism and risk of PCOS: a study in the South Indian Women

28 citations , August 2014 in “Journal of Assisted Reproduction and Genetics”

The VEGF +405G allele may increase the risk of PCOS in South Indian women.

research Integrated safety analysis of baricitinib in adults with severe alopecia areata from two randomized clinical trials

25 citations , November 2022 in “British journal of dermatology/British journal of dermatology, Supplement”

Baricitinib for severe alopecia areata is generally safe, with common side effects like infections and acne, and low rates of serious complications.

research Novel cycle changes in scalp hair are caused by etretinate therapy

24 citations , March 1995 in “British Journal of Dermatology”

Etretinate therapy can cause hair loss by disrupting the hair growth cycle.

Cicatricial (Scarring) Alopecia: Clinical Presentations, Etiologies, and Histopathologic Features

research Cicatricial (scarring) alopecia

13 citations , April 2001 in “International Journal of Dermatology”

Different types of scarring alopecia may be stages of one disease, and accurate diagnosis is crucial to prevent permanent hair loss.

A Disease-Causing Novel Missense Mutation in the ST14 Gene Underlies Autosomal Recessive Ichthyosis with Hypotrichosis Syndrome in a Consanguineous Family

research A disease-causing novel missense mutation in the ST14 gene underlies autosomal recessive ichthyosis with hypotrichosis syndrome in a consanguineous family

9 citations , March 2018 in “European journal of dermatology/EJD. European journal of dermatology”

A new mutation in the ST14 gene causes a rare skin and hair disorder in a specific family.

research A 17-Year-Old Mother Seeking Contraception

8 citations , October 1996 in “JAMA”

The document suggests a young mother use effective contraception like the Copper-T IUD while considering her health and the need for STD prevention.

research Keratin function and regulation in tissue homeostasis and pathogenesis

7 citations , April 2012 in “Biomolecular concepts”

Keratin is crucial for keeping skin cells healthy and its changes can lead to diseases and affect cell behavior.

research A new locus for hereditary hypotrichosis simplex maps to chromosome 13q12.12∼12.3 in a Chinese family

7 citations , May 2010 in “Journal of Cutaneous Pathology”

A new genetic area linked to a rare hair loss condition was found on chromosome 13 in a Chinese family.

research Hereditary vitamin D-resistant rickets in Lebanese patients: the p.R391S and p.H397P variants have different phenotypes

4 citations , January 2017 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism”

Two different mutations in the vitamin D receptor gene cause different symptoms and responses to treatment in Lebanese patients with hereditary rickets.

Cutaneous Drug Eruptions Associated with the Use of Biologics and Cutaneous Drug Eruptions Mimicking Specific Skin Diseases

research Cutaneous Drug Eruptions Associated with the Use of Biologies and Cutaneous Drug Eruptions Mimicking Specific Skin Diseases

4 citations , January 2012 in “Chemical Immunology”

Some drugs, especially biologics, can cause skin reactions that look like other skin diseases, and stopping the drug usually helps clear up these reactions.

research Restorative effect of hair follicular dermal cells on injured human hair follicles in a mouse model

4 citations , January 2015 in “Experimental Dermatology”

Human hair follicle dermal cells can help repair damaged hair follicles.

Genotypes of Single-Nucleotide Polymorphisms on DENND1A in Association with Polycystic Ovary Syndrome Among Saudi Arabian Females

research Genotypes of Single-nucleotide polymorphisms on DENND1A in an association with polycystic ovary syndrome among Saudi Arabian females

July 2025

SNP rs2479106 in the DENND1A gene may increase PCOS risk in Saudi Arabian females.