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Did you mean Diacylglycerol O-Acyltransferase 1?

GlossaryDiacylglycerol O-Acyltransferase 1

enzyme that catalyzes the final step in triglyceride synthesis

Diacylglycerol O-Acyltransferase 1 (DGAT1) is an enzyme that plays a crucial role in the body's ability to store fat. It catalyzes the final step in the synthesis of triglycerides, which are the main form of stored energy in fat cells. This enzyme is important for energy metabolism and has been studied for its potential links to obesity and metabolic disorders.

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The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner

research The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5‐Independent Manner

May 2025 in “Experimental Dermatology”

Triphenylphosphine oxide can increase oil production and reduce inflammation in skin cells without affecting TRPM5.

research 696 MEK and BRAF inhibitors augment the production and accumulation of sebum in hamster sebocytes

April 2016 in “Journal of Investigative Dermatology”

MEK and BRAF inhibitors increase sebum production and accumulation, which could cause acne-like side effects.

research The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters

258 citations , July 2005 in “Journal of lipid research”

DGAT1 enzyme helps make diacylglycerols, waxes, and retinyl esters.

research The acyl-CoA binding protein is required for normal epidermal barrier function in mice

31 citations , July 2012 in “Journal of Lipid Research”

ACBP is crucial for healthy skin in mice.

research Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia

14 citations , October 2018 in “PloS one”

Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.

research Potential role and therapeutic interests of myo-inositol in metabolic diseases

369 citations , June 2013 in “Biochimie”

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

research Syndromes of Severe Insulin Resistance (SSIRs)

November 2004

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

research Decay of Skin-Specific Gene Modules in Pangolins

1 citations , May 2023 in “Journal of molecular evolution”

Pangolins have lost some skin-related genes, but kept others, leading to their unique scales and skin features.

research Endogenous retinoids in the hair follicle and sebaceous gland

50 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

research Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

124 citations , June 2020 in “Cell Stem Cell”

Fat cells in the skin help start healing and form important repair cells after injury.

research Circadian clocks: from stem cells to tissue homeostasis and regeneration

84 citations , December 2017 in “EMBO Reports”

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

research Dermal niche signaling and epidermal stem cells

January 2019 in “Advances in stem cells and their niches”

Skin health and repair depend on the signals between skin stem cells and their surrounding cells.

research Adipocytes in Skin Health and Disease

77 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

research Hair cycle control by leptin as a new anagen inducer

41 citations , November 2013 in “Experimental Dermatology”

Leptin, a hormone, is important for starting hair growth.

Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

research Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome

200 citations , October 2009 in “European journal of endocrinology”

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

research Beyond acne: Current aspects of sebaceous gland biology and function

97 citations , September 2016 in “Reviews in Endocrine and Metabolic Disorders”

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex

research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract ofQuercus acutissimaCortex

37 citations , January 2015 in “Evidence-based Complementary and Alternative Medicine”

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Low Humidity Alters Epidermal Gene Expression in vivo

February 2026 in “Clinical Cosmetic and Investigational Dermatology”

Low humidity changes skin gene expression, but emollients can help manage these changes.

research A guide to studying human dermal adipocytes in situ

21 citations , March 2018 in “Experimental Dermatology”

The guide explains how to study human skin fat cells and their tissue, aiming to improve research and medical treatments.

research A review of adipocyte lineage cells and dermal papilla cells in hair follicle regeneration

35 citations , January 2014 in “Journal of Tissue Engineering”

Cell-based therapies using dermal papilla cells and adipocyte lineage cells show potential for hair regeneration.

research Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances

112 citations , May 2019 in “Pharmacological Research”

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research Development and homeostasis of the sebaceous gland

107 citations , August 2012 in “Seminars in Cell & Developmental Biology”

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

research An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

23 citations , December 2020 in “Frontiers in Cell and Developmental Biology”

Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.

research The Role of Non-Aromatizable Testosterone Metabolite in Metabolic Pathways

21 citations , April 2011 in “Physiological Research”

Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

Genetic Ablation of Myelin Protein Zero-Like 3 in Mice Increases Energy Expenditure, Improves Glycemic Control, and Reduces Hepatic Lipid Synthesis

research Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis

14 citations , May 2013 in “American Journal of Physiology-endocrinology and Metabolism”

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.