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GlossaryDifferentially Expressed miRNAs

small RNA molecules with varying expression levels in different conditions

Differentially Expressed miRNAs (microRNAs) are small RNA molecules that show different levels of expression in different conditions, such as between healthy and diseased tissues. These variations can help identify specific biological processes or pathways that are altered in conditions like alopecia, providing insights into potential targets for treatment or diagnosis.

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research 496 Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers found that certain miRNAs, which affect immune system regulation, are differently expressed in mice with a hair loss condition compared to healthy mice.

research Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways

14 citations , March 2017 in “Genes and immunity”

Certain microRNAs may help treat alopecia areata by targeting immune pathways.

research Integrated analysis of miRNAs and mRNA profiling reveals the potential roles of miRNAs in sheep hair follicle development

5 citations , October 2022 in “BMC genomics”

Certain microRNAs are important for sheep hair follicle development and could help improve wool quality.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

The research found genes and miRNAs that may control hair growth in Forest Musk Deer.

research Integrated Analysis of miRNAs and mRNA Profiling Reveals the Potential Role of miRNAs in Sheep Hair Follicle Development

July 2022 in “Research Square (Research Square)”

Certain miRNAs may play a role in sheep hair follicle development, which could help improve wool production.

research Comparative Analysis of mRNA and miRNA Expression between Dermal Papilla Cells and Hair Matrix Cells of Hair Follicles in Yak

December 2022 in “Cells”

Different genes and pathways are active in yak skin and hair cells, affecting hair growth and immune responses.

research Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

24 citations , May 2022 in “BMC Veterinary Research”

lncRNAs play a key role in hair follicle development, affecting cashmere quality and yield.

research Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats’ Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

2 citations , July 2023 in “Animals”

FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.

research 202 MicroRNAs in the pathogenesis of male pattern baldness

August 2016 in “Journal of Investigative Dermatology”

Different levels of microRNAs in different parts of the scalp can cause male pattern baldness.

research An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats

26 citations , April 2019 in “Genes”

lncRNA XLOC_008679 and gene KRT35 affect cashmere fineness in goats.

research Identification of Potential Hub Genes in Alopecia Areata

4 citations , October 2024 in “Experimental Dermatology”

CD8A and FOXD2-AS1 may be key for diagnosing and treating alopecia areata.

research Molecular Basis of Maintaining Circannual Rhythm in the Skin of Cashmere Goat

1 citations , April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Goat skin changes with the seasons due to genes affected by daylight and hormones.

Whole-Transcriptome RNA Sequencing Reveals Global Expression Dynamics and ceRNA Regulatory Networks Related to Hair Follicle Development and Melanogenesis in Goats

research Whole-transcriptome RNA sequencing reveals global expression dynamics and ceRNA regulatory networks related to hair follicle development and melanogenesis in goats

March 2025 in “Animal Bioscience”

Goats' hair and color traits are linked to specific RNA expressions, useful for breeding and textiles.

research Molecular Basis of Maintaining Circannual Rhythm in the Skin of Cashmere Goat 

September 2020 in “Research Square (Research Square)”

Goat skin adapts to seasonal changes through genes that respond to daylight length, affecting hormone levels and potentially making skin cells light-sensitive.

Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data

research Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data

7 citations , July 2018 in “Journal of Investigative Dermatology”

Gene differences found in hair follicles linked to male baldness.

research 139 Identification of long noncoding RNAs in mouse hair follicle stem cells using computational methods

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists found new and known long non-coding RNAs in mouse hair follicle stem cells that may be important for stem cell function and could be targets for cancer treatment.

Network Analysis Reveals Potential Mechanisms That Determine the Cellular Identity of Keratinocytes and Corneal Epithelial Cells Through the Hox/Gtl2-Dio3 miRNA Axis

research Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis

January 2025 in “Frontiers in Cell and Developmental Biology”

Hox proteins help maintain keratinocyte identity by regulating miRNA expression.

research Integrated miRNA-mRNA analysis reveals regulatory pathways underlying the curly fleece trait in Chinese tan sheep

17 citations , May 2018 in “BMC genomics”

Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.

research Discovery and Functional Analysis of Secondary Hair Follicle miRNAs during Annual Cashmere Growth

3 citations , January 2023 in “International journal of molecular sciences”

Certain miRNAs play a key role in the growth of cashmere by affecting hair follicle development and regeneration.

research Integrated miRNA and mRNA Analysis Provides New Insight into Mechanism of dermal papilla in Androgenetic Alopecia

June 2024 in “Research Square (Research Square)”

Increased cell death and reduced cell growth in hair follicles contribute to baldness.

research Application of lncRNA-miRNA-mRNA ceRNA network analysis in the treatment of androgenic alopecia.

1 citations , December 2022 in “PubMed”

The lncRNA LOXL1-AS1 may help diagnose and treat androgenic alopecia.

research The Identification and Characteristics of miRNAs Related to Cashmere Fiber Traits in Skin Tissue of Cashmere Goats

5 citations , February 2023 in “Genes”

Certain miRNAs may influence cashmere fiber traits in goats by affecting hair follicle activities.

research Transcriptomes reveal microRNAs and mRNAs in different photoperiods influencing cashmere growth in goat

1 citations , March 2023 in “PloS one”

Different amounts of daylight affect cashmere growth in goats by changing the activity of certain genes and molecules.

Transcriptome Sequencing Reveals the Expression Profiles of lncRNAs and mRNAs in Goat Skin Tissues With Different Types of Wool Coats

research Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats

1 citations , May 2025 in “Scientific Reports”

The study identified key genes and pathways that influence goat wool quality and growth.

research Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin

37 citations , May 2018 in “Frontiers in physiology”

Certain RNA molecules are important for the development of wool follicles in sheep.

Transcriptome Sequencing Reveals Expression Profiles of lncRNAs and mRNAs in Goat Skin Tissues with Different Wool Coat Types

research Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats

April 2025

Different wool coat types in goats are linked to specific gene expressions, which could improve cashmere quality.

research Identification of microRNAs involved in growth arrest and cell death in hydrogen peroxide-treated human dermal papilla cells

12 citations , April 2014 in “Molecular Medicine Reports”

Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.

research Identification and profiling of microRNA between back and belly Skin in Rex rabbits (Oryctolagus cuniculus)

1 citations , June 2018 in “World rabbit science”

Different miRNAs in Rex rabbit skin affect cell processes and hair growth.

research Analysis of LncRNA and mRNA Expression Profiles in Skin Tissues of Super Merino Sheep and Small-Tailed Han Sheep

November 2023

Researchers found genes in sheep that may affect hair growth and wool quality.

research An Integrated Analysis of MicroRNA and mRNA Expression Profiles to Identify RNA Expression Signatures in Lambskin Hair Follicles in Hu Sheep

22 citations , July 2016 in “PLoS ONE”

Certain miRNAs and genes influence wave patterns in Hu sheep hair follicles.