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930-960 / 1000+ resultsresearch Synthesis of mimics of steroid A ring as potential enzyme inhibitors
Mimicking the steroid A-ring may help create effective enzyme inhibitors for prostate disease treatment.
research Synergistic effect of carbodiimide and dehydrothermal crosslinking on acellular dermal matrix
Combining DHT and EDC improves the strength and stability of PADM scaffolds for tissue engineering.
research The targeted overexpression of a Claudin mutant in the epidermis of transgenic mice elicits striking epidermal and hair follicle abnormalities
research Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening
The Spherical Skin Model improves drug and cosmetic testing by accurately mimicking human skin for efficient compound screening.
research HAIR COAT AND STEROIDAL IMPLANT EFFECTS ON STEERS GRA ZING NDOPHYTE-INFECTED TALL FESCUE DURING THE SUMMER
Steers with winter hair coats and reduced sweating struggled with heat, leading to less grazing and poor performance.
research Zinc‐Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post‐Pancreatectomy Cutaneous Wound Healing
The zinc-coordinated nanogel therapy speeds up wound healing after pancreas surgery by balancing metabolism and fighting bacteria.
research Functional characterization and unraveling the structural determinants of novel steroid hydroxylase CYP154C7 from Streptomyces sp. PAMC26508
CYP154C7 enzyme can effectively modify steroids and is promising for commercial use.
research Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling
SH-340 may improve skin barrier and help treat atopic dermatitis.
research Parasitic angiosperms, semagenesis and general strategies for plant–plant signaling in the rhizosphere
Reactive oxygen species are key for parasitic plant attachment and affect root development in various plants.
research A Biodegradable Supramolecular Adhesive with Robust Instant Wet Adhesion for Urgent Hemostasis and Wound Repair
The adhesive quickly stops bleeding and repairs wounds in wet conditions.
research Pyrene Excimer Nucleic Acid Probes for Biomolecule Signaling
Pyrene excimer nucleic acid probes are promising for detecting biomolecules accurately with potential for biological research and drug screening.
research Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida
Sterculia foetida seed extract shows promise for therapeutic use due to its anti-inflammatory and pain-relief properties.
research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways
Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.
research ToF‐SIMS characterization of the lipid layer on the hair surface. II : Effect of the 18‐MEA lipid layer on surface hydrophobicity
18-MEA is essential for hair's water resistance, and a conditioner with 18-MEA and SPDA can restore it.
research 965 The importance of CD206+ macrophages in squaric acid dibutylester-induced hair cycle activation
CD206+ macrophages are crucial for hair growth in alopecia areata treatment.
research ISID1448 – Ligand-dependent Wnt signaling attenuates mechanotransduction and protects against wound occlusion-mediated abolishment of hair follicle regeneration
research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis
Increasing SSAT makes skin more prone to cancer.
research Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.
Neuroactive steroids affect cocaine's rewarding effects through the sigma1 receptor.
research Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome
Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.
research Carbon quantum dots applied to the chemical sensing of cobalt ions and methylcobalamin
Carbon Quantum Dots can effectively detect cobalt ions and methylcobalamin in water.
research 1331 Glutathione (GSH) distribution by quantitative MALDI imaging in reconstructed human skin upon activation of GSH biosynthesis by Nrf2 pathway activator
Resveratrol activates the Nrf2 pathway in human skin, significantly increasing the production and distribution of the antioxidant glutathione.
research Drug Discovery Insights from a Computational QSAR Study on Alpha-Reductase Inhibitors and Layered Double Hydroxides Electrocatalysts
Computational techniques can improve drug development for treating certain conditions.
research Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery
The new dutasteride formula can be applied to the skin, may promote hair growth, and has fewer side effects.
research An injectable photocuring silk fibroin-based hydrogel for constructing an antioxidant microenvironment for skin repair
The hydrogel speeds up wound healing and improves skin repair better than commercial options.
research Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents
Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.
research Table 1_Contact sensitization to hair care allergens in scalp seborrheic dermatitis: associations with disease severity and microbiota profiles.docx
Allergen reactivity in scalp seborrheic dermatitis should be managed with barrier repair and microbiome-focused strategies.
research Rapidly Gelling Sprayable Hydrogels Integrating Carbon Quantum Dots and Plant Extracellular Vesicles Enable Multifunctional Wound Care via Photothermal Management, Immunomodulation, and Ferroptosis
A new sprayable hydrogel helps heal wounds faster and reduces inflammation.
research Subcision: A Further Modification, an Ever Continuing Process
New subcision technique with a bent needle and syringe improves ease, effectiveness, and comfort for treating acne scars.
![[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs](/images/research/4eb017dc-711d-4926-bcd0-c3b8f48e3a99/small/19974.jpg)
research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs
ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.