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Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

53 citations , October 2014 in “Free radical biology & medicine”

Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.

Novel Synthesis of Nicotinamide Derivatives with Cytotoxic Properties

research Novel synthesis of nicotinamide derivatives of cytotoxic properties

51 citations , March 2006 in “Bioorganic & Medicinal Chemistry”

Newly made nicotinamide compounds could potentially treat cancer.

research Promotion of homology-directed DNA repair by polyamines

47 citations , January 2019 in “Nature communications”

Polyamines help fix DNA damage accurately in cells.

research Strengthening the Skin with Topical Delivery of Keratinocyte Growth Factor-1 Using a Novel DNA Plasmid

23 citations , January 2014 in “Molecular Therapy”

Applying a special DNA plasmid to the skin can make it thicker and stronger.

Hypothalamic DNA Methylation in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome: Effects of Low-Frequency Electro-Acupuncture

research Hypothalamic DNA methylation in rats with dihydrotestosterone‐induced polycystic ovary syndrome: effects of low‐frequency electro‐acupuncture

18 citations , September 2018 in “Experimental physiology”

Electro-acupuncture may help treat PCOS in rats by changing brain DNA methylation.

research Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2

9 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

research Promotion of hair growth by newly synthesized ceramide mimetic compound

8 citations , July 2017 in “Biochemical and biophysical research communications”

A new compound, BOI, can help hair grow by changing hair cycle phases and increasing certain cell contents.

Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase

5 citations , July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research Araliadiol Protects Human Keratinocytes From Oxidative Stress, DNA Damage, and Apoptosis via Activation of Antioxidant Signaling

January 2026 in “Frontiers in Bioscience-Landmark”

Araliadiol protects skin cells from damage by boosting antioxidant defenses.

research DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging

December 2025 in “Clinical Cosmetic and Investigational Dermatology”

ZDHHC17 methylation may help treat or identify facial skin aging.

Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence

research Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence

January 2024 in “GeroScience”

Using radiation to make mice's hair turn gray helps study and find ways to prevent or reverse hair graying.

Modeling Androgen Synthesis and Action During Human Sexual Differentiation

research Modelling androgen synthesis and action during human sexual differentiation

February 2010 in “ePrints Soton (University of Southampton)”

Male sexual differentiation is regulated independently, while female differentiation occurs in an androgenic environment, affecting conditions like congenital adrenal hyperplasia.

research An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging

12 citations , December 2021 in “Aging”

A new painless method to collect hair follicles helps study DNA damage and aging.

research A Simple Method to Extract DNA from Hair Shafts Using Enzymatic Laundry Powder

8 citations , July 2013 in “PLoS ONE”

DNA can be quickly and effectively extracted from hair using laundry powder.

research Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

45 citations , August 2005 in “Bioorganic & medicinal chemistry”

New compounds with carborane showed anti-androgen effects similar to flutamide.

Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner

research Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

42 citations , December 2016 in “Cell Death & Differentiation”

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

Genetic Ablation of Myelin Protein Zero-Like 3 in Mice Increases Energy Expenditure, Improves Glycemic Control, and Reduces Hepatic Lipid Synthesis

research Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis

14 citations , May 2013 in “American Journal of Physiology-endocrinology and Metabolism”

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety

research Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety

7 citations , August 2019 in “Bioorganic & medicinal chemistry”

Analog 23 is a promising compound for prostate cancer treatment.

research Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents

6 citations , January 2016 in “Bioorganic & Medicinal Chemistry Letters”

Some minoxidil combinations can help differentiate leukemia cells without harming other cells.

Synthesis of Cu4O3 Nanoparticles Using Pumpkin Seed Extract: Optimization, Antimicrobial, and Cytotoxicity Studies

research Synthesis of Cu ₄ O ₃ nanoparticles using pumpkin seed extract: Optimization, antimicrobial, and cytotoxicity studies

January 2025 in “Nanotechnology Reviews”

Pumpkin seed extract can create copper oxide nanoparticles with potential antibacterial and cancer-fighting properties.

Dermapen Treatments for Healing Pockmarked Skin in Male Wistar Rats (Rattus Norvegicus): A Study Comparing Platelet-Rich Plasma with Salmon DNA Serum

research Dermapen Treatments for Healing Pockmarked Skin in Male Wistar Rats (Rattus norvegicus): A Study Comparing Platelet-Rich Plasma with Salmon DNA Serum

December 2023 in “Jurnal Penelitian Pendidikan IPA”

PRP heals pockmarked skin better than salmon DNA serum.

Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes

research Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota

14 citations , January 2020 in “International Journal of Biological Sciences”

Ranitidine and finasteride lower TMAO levels, reducing heart and kidney damage by changing gut bacteria.

Pantothenic Acid Promotes Dermal Papilla Cell Proliferation in Hair Follicles of American Minks via Inhibitor of DNA Binding 3/Notch Signaling Pathway

research Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway

11 citations , April 2020 in “Life sciences”

Pantothenic acid helps mink hair follicles grow by affecting certain cell signals.

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