research Past and Future Strategies for GPCR Deorphanization
Finding functions for unknown GPCRs is hard but key for making new drugs.
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960-990 / 1000+ results research Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole
Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.
research Prevention and treatment of adverse effects related to chemotherapy for recurrent ovarian cancer
Nurses are crucial in managing chemotherapy side effects for ovarian cancer patients to improve their quality of life.
research The N‑K Healing Series: Complete Geometric Restoration for Wounds, Pain, and Burns PAIN-GM1, REGEN-GM1, and BURN-GM1 — Complete Geometric Analysis Using N‑K Universal Computer, 1 Million Virtual Injuries Simulated, 100% Accuracy Comparison with Mainstream Medicine — Why Current Treatments Fail and How N‑K Geometry Succeeds
N-K Geometric Medicine heals wounds, pain, and burns better and faster than current treatments, without side effects.
research The N‑K Healing Series: Complete Geometric Restoration for Wounds, Pain, and Burns PAIN-GM1, REGEN-GM1, and BURN-GM1 — Complete Geometric Analysis Using N‑K Universal Computer, 1 Million Virtual Injuries Simulated, 100% Accuracy Comparison with Mainstream Medicine — Why Current Treatments Fail and How N‑K Geometry Succeeds
N-K Geometric Medicine heals wounds, pain, and burns better and faster than current treatments, without side effects.
research Platelet-rich plasma and fat grafting for the treatment of inferior alveolar nerve neuropathy: The first case report
Using platelet-rich plasma and fat grafting to treat nerve pain showed promising results with no side effects.
research The role of oclacitinib in the management of ischaemic dermatopathy in four dogs
Oclacitinib effectively treated a skin condition in dogs that didn't respond to other immunosuppressants.
research Successful deslorelin implant treatment in a neutered female Pomeranian dog with Alopecia X
Deslorelin implant successfully regrew hair in a female Pomeranian with alopecia X.
research SAT-127 Localization and Treatment of the Ectopic ACTH Syndrome Using Somatostatin Analogues
Somatostatin analogues effectively manage ectopic ACTH syndrome when surgery isn't possible.
research Abstract P5-09-21: Selective androgen receptor modulators (SARMs): Enobosarm as targeted therapy for the treatment of androgen receptor-positive breast cancer
Enobosarm may effectively treat androgen receptor-positive breast cancer with fewer side effects.
research Can we teach old drugs new tricks?—Repurposing of neuropharmacological drugs for inflammatory skin diseases
Old neuropharmacological drugs might be effective for treating inflammatory skin diseases.
research Most recent findings of curative drugs for lower urinary tract symptoms in clinical practice
Current treatments for lower urinary tract symptoms include α1-blockers, 5ARIs, PDE5 inhibitors, anticholinergic agents, and β3-adrenergic receptor agonists.
research Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing
Activating ER-β, not ER-α, improves skin cell growth and wound healing.
research Formulasi dan Evaluasi Sediaan Axillary Krim Ekstrak Kunyit (Curcuma longa Linn.) dengan Kombinasi Jahe (Zingiber officinale) sebagai Penghambat Pertumbuhan Bulu pada Aksila
The cream with turmeric and ginger extracts can potentially reduce underarm hair growth effectively.
research Dutasteride infusion in male androgenetic alopecia using a novel drug delivery technique: MMP®
Dutasteride microinfusion and microneedling both effectively treat male hair loss.
research Bioabsorbable nano-micelle hybridized hydrogel scaffold prevents postoperative melanoma recurrence
A special gel with medicine helps prevent melanoma from coming back after surgery.
research Estrogens
research Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic Alopecia: A Pilot Study
Skin patting and iontophoresis with dutasteride gel improved hair growth in people with androgenetic alopecia.
research Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice
Natural honey protects against Doxorubicin's harmful effects.
research Direct Vasodilators and Sympatholytic Agents
Direct vasodilators and sympatholytic agents are still useful for certain conditions despite being less common due to side effects and newer drugs.
research Lokivetmab improved pruritus in a dog with cutaneous epitheliotropic lymphoma
Lokivetmab reduced itching in a dog with skin lymphoma.
research Experience with sonidegib in patients with advanced basal cell carcinoma: case reports
Sonidegib effectively treated advanced basal cell carcinoma with mild side effects.
research Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications
Special gels help heal diabetic foot sores and reduce the risk of amputation or death.
research Synergistic therapeutic effect of systemic steroids and dithranol in a patient of alopecia totalis—A case report
Combining systemic steroids and dithranol can effectively regrow hair in severe alopecia areata.
research Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery
Polymeric microneedles offer a less invasive, long-lasting drug delivery method that improves patient compliance and reduces side effects.
research Combined AlloDerm® and thin skin grafting for the treatment of postburn dyspigmented scar contracture of the upper extremity
Technique effectively treats deformities, achieves re-pigmentation, and releases scar contractures.
research Advances in nitric oxide-releasing hydrogels for biomedical applications
![Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)](/images/research/d743d32f-3115-48ff-9697-2f2d56130701/small/14175.jpg)
research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)
The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.
research Capryloyl glycine and soy isoflavonoids in hypertrichosis: An experimental and placebo‐controlled clinical study
The cream effectively reduced hair growth on forearms.
research 468 Use of calcitonin gene-related peptide monoclonal antibodies in patients with rosacea: An exploratory, comparative case series
CGRP MAbs treatment for migraines may also improve rosacea symptoms, but more research is needed to confirm its effectiveness and safety.