These medications for BPH have known risks and may have new side effects.
October 2024 in “Iraqi postgraduate medical journal” 
March 2026 in “Critical Care Medicine” Methylene blue can effectively treat severe low blood pressure from minoxidil overdose when standard treatments fail.
5 citations
,
September 2024 in “Maturitas” The study evaluated the efficacy of an ultra-low dose combination of 0.5 mg estradiol and 0.25 mg dydrogesterone in alleviating vasomotor symptoms in a multi-ethnic population of 583 postmenopausal women from Europe and China. Participants were randomized to receive the treatment or a placebo for 12 weeks. Results showed a significant reduction in the number of hot flushes per day with the treatment compared to placebo, along with improvements in health-related quality of life, including psychological symptoms and vaginal dryness. The treatment was well tolerated, with no significant differences in serious adverse events or changes in body weight between the groups. The study concludes that this treatment is consistently effective for menopause-related symptoms across different ethnicities.
11 citations
,
December 2011 in “PubMed” 5% minoxidil solution effectively treats hair loss in men and women.
1 citations
,
December 2019 in “Journal of medicine and life science” Docosahexaenoic acid (DHA) may help hair growth by promoting dermal papilla cell proliferation.
49 citations
,
December 1997 in “Urology” Tamoxifen effectively treats gynecomastia without causing impotence.
4 citations
,
June 2017 in “Irish veterinary journal” The deltamethrin solution effectively and safely treats and prevents lice in horses for up to one month.
33 citations
,
January 2009 in “Contraception” Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.
306 citations
,
August 2011 in “Journal of cachexia, sarcopenia and muscle” Enobosarm significantly increased muscle mass and improved physical function in elderly men and postmenopausal women without serious side effects.
January 2021 in “International Journal of Research in Dermatology” Combination therapies are more effective for treating androgenetic alopecia than single treatments.
16 citations
,
March 2020 in “Journal of The American Academy of Dermatology” Oral bicalutamide is safe and effective for female hair loss.
40 citations
,
January 2013 in “Clinical Cosmetic and Investigational Dermatology” Desonide is more effective than niacinamide for reducing underarm darkening.
1 citations
,
April 2025 in “Drug Delivery and Translational Research” 
36 citations
,
July 1977 in “The Journal of Pediatrics” Minoxidil helps lower blood pressure in kids with severe hypertension, but may cause temporary excessive hair growth.
July 2025 in “SKIN The Journal of Cutaneous Medicine” Adding dupilumab led to almost complete hair regrowth in a patient with alopecia areata who only partially responded to baricitinib.
14 citations
,
December 1998 in “The Journal of Clinical Endocrinology and Metabolism” MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.
36 citations
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March 1989 in “British journal of dermatology/British journal of dermatology, Supplement” DPCP is more effective than tretinoin gel for treating severe alopecia.
1 citations
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October 2006 in “Urology” Alpha-blocker therapy may not be needed long-term when combined with finasteride for BPH.
December 2024 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft” Deucravacitinib helped a man regrow hair significantly.
62 citations
,
January 2004 in “PubMed” 5alpha-reductase inhibitors like finasteride and dutasteride effectively treat BPH by reducing DHT, offering symptom relief and potential future uses.
June 2023 in “Journal of chemical metrology” A new method found unlisted drugs in two popular hair serums, posing a health risk.
January 2023 in “Skin appendage disorders” Low-dose oral minoxidil may help treat hair loss but is not FDA-approved and can cause side effects like unwanted hair growth and heart issues.
Some drugs can reduce male semen quality.
2 citations
,
September 2024 in “PLoS ONE” Bendamustine combined with tucidinostat may effectively treat adult T-cell leukemia.
January 2026 in “Yonsei Medical Journal” Finasteride and dutasteride have little effect on Type 2 Diabetes risk.
2 citations
,
February 2023 in “Actas Dermo-Sifiliográficas” Baricitinib effectively improved both atopic dermatitis and alopecia areata symptoms in a patient.
August 2025 in “Archives of Dermatological Research” Oral minoxidil may help with pediatric hair disorders but has notable side effects.
23 citations
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June 1993 in “PubMed” Medication 1 improved hair quality and growth more effectively than medication 2 and the placebo.
December 2024 in “Asian Journal of Pharmaceutical and Clinical Research” Adding PRP to minoxidil and finasteride is more effective for hair loss.