May 2022 in “The Journal of Clinical Pharmacology” Metformin reduces certain hormone levels in men with early-onset hair loss.
December 2021 in “Biomarkers” Men with early baldness have similar heart risk factors as others, but certain proteins are linked to higher heart disease risk.
July 2020 in “Benha Journal of Applied Sciences” Young men with early hair loss and high SAA3 levels are at higher risk for heart disease.
3 citations
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June 2022 in “Journal of the European Academy of Dermatology and Venereology” COVID-19 may cause early hair loss by infecting hair follicles.
1 citations
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August 2021 in “Journal of The American Academy of Dermatology” Baricitinib was effective in treating both early and late onset alopecia areata.
October 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Six new genes linked to early hair loss were found, which also surprisingly connect to Parkinson's disease and lower fertility.
October 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Six new genes linked to early hair loss were found, which also surprisingly connect to Parkinson's disease and lower fertility.
June 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Six new risk spots for early hair loss were found, which also link to Parkinson's disease and lower fertility. Two genes, FOXA2 and HDAC4, could be new treatment targets. Hair loss might also be connected to heart disease, metabolic syndrome, and prostate cancer.
195 citations
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June 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
2 citations
,
May 2023 in “Anais Brasileiros de Dermatologia”
October 2025 in “Communications Medicine” Combining genetic and physical data improves diagnosis and treatment for early-onset monogenic diabetes.
A rare skin condition in a 17-year-old was diagnosed late, stressing the need for careful evaluation and genetic testing.
July 2022 in “British Journal of Dermatology” October 2021 in “QJM: An International Journal of Medicine” N-acetyl-cysteine improves hair growth and is safe for treating early male hair loss.
January 2025 in “International Journal of Medicine in Developing Countries” Many in Saudi Arabia experience early hair loss but lack awareness of treatments.
5 citations
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June 2021 in “Pharmacological Reports” Vitamin D may help reduce antibody levels in men with autoimmune thyroiditis and early-onset androgenic alopecia, but has no significant impact on thyroid function.
3 citations
,
May 2024 in “BMC Medical Genomics” A new ARID1B gene variation causes Coffin-Siris syndrome 1 and early high myopia in a Chinese family.
2 citations
,
July 2021 in “Journal of Cardiovascular Pharmacology” Lisinopril improves heart health more in men with normal hair than those with early hair loss.
1 citations
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December 2017 in “Turkderm” People with a family history of hair loss are more likely to experience it, and the severity of hair loss is linked to insulin resistance. The connection between early hair loss and oxidative stress needs more investigation.
July 2022 in “British Journal of Dermatology”
May 2025 in “Clinical Endocrinology” Metformin lowers prolactin in men with normal hair but not in those with early hair loss.
2 citations
,
January 2025 in “Allergy” Having asthma, atopic dermatitis, or Hashimoto's thyroiditis increases the risk of severe and long-lasting alopecia areata.
2 citations
,
January 2018 in “Annals of Dermatology” Early hair loss may be linked to metabolic syndrome.
1 citations
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December 2023 in “Experimental Dermatology” Children with alopecia areata before age 4 may have better short-term hair regrowth.
February 2026 in “Mendeley Data” Early hair loss may indicate higher risk of diabetes and heart disease.
Early combination therapy can effectively regrow hair in frontal fibrosing alopecia.
29 citations
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February 2019 in “Environment international” Higher early lead exposure is linked to delayed puberty in girls.
58 citations
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December 2018 in “Nature Communications” Male pattern baldness is mostly inherited, involves many genes, and is linked to other traits like early puberty and strong bones.
48 citations
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May 2015 in “PLOS ONE” DNA variants can predict male pattern baldness, with higher risk scores increasing baldness likelihood.
38 citations
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February 2012 in “British Journal of Dermatology” AR/EDA2R gene linked to early-onset female hair loss, but 20p11 gene not involved.