research Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF Activation
Plerixafor may help treat pigmentation disorders by promoting skin repigmentation.
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research Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying
Lack of a certain enzyme causes hair to grey early by damaging stem cells, but an antioxidant can help prevent this.
research Dissecting the Impact of Chemotherapy on the Human Hair Follicle
Chemotherapy damages hair follicles, causing hair loss and other cellular changes.
research Chemotherapy Targets the Hair-Follicle Vascular Network but Not the Stem Cells
Chemotherapy affects blood vessels in hair follicles, not stem cells, allowing hair regrowth.
research Prevention of chemotherapy drug-mediated human hair follicle damage: combined use of cooling with antioxidant suppresses oxidative stress and prevents matrix keratinocyte cytotoxicity
Cooling with antioxidants helps protect hair during chemotherapy.
research Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis
New hair follicles could be created to treat hair loss.
research Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study
N-acetylcysteine may prevent hair loss caused by chemotherapy.
research Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
Fat tissue under the skin affects hair growth and aging; reducing its inflammation may help treat hair loss.
research Emerging interactions between skin stem cells and their niches
Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
research Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells
Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.
research Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications
Melanocyte stem cells are crucial for skin pigmentation and have potential in disease modeling and regenerative medicine.
research Three Streams for the Mechanism of Hair Graying
Hair graying may be caused by stem cell depletion from stress or melanocyte damage.
research Wnt/β-catenin signaling promotes aging-associated hair graying in mice
A certain signaling pathway in mice, when increased, causes hair to gray by depleting the cells that give hair its color.
research Birth, life, and death of the MAGE3 hypothesis of alopecia areata pathobiology
The MAGE3 hypothesis for alopecia areata did not lead to a significant breakthrough.
research SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling
SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.
research BMI1 is required for melanocyte stem cell maintenance and hair pigmentation
BMI1 is essential for preventing hair greying and maintaining hair color.
research Down-regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in XenopusMelanophores
Agouti protein affects melanocortin receptors through competitive antagonism and receptor down-regulation.
research Concise Review: Translating Regenerative Biology into Clinically Relevant Therapies: Are We on the Right Path?
We need to understand more about regeneration to improve human tissue healing.
research Alopecia totalis successfully treated with modified platelet-rich plasma therapy in a patient recalcitrant to traditional treatment modalities
Modified PRP therapy successfully treated severe alopecia unresponsive to traditional methods.
research Hair loss severity and its impact on quality of life in patients suffering from androgenic alopecia: A one-year cross-sectional study
Severe hair loss significantly worsens quality of life.
research Headcover and male-pattern hair loss: A cross-sectional study
Wearing headcovers doesn't affect male-pattern hair loss severity.
research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions
Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.
research Miz1 is required for hair follicle structure and hair morphogenesis
Miz1 is essential for proper hair structure and growth.
research Human Hair Graying Revisited: Principles, Misconceptions, and Key Research Frontiers
Hair graying is caused by damage and cell depletion but might be temporarily reversible with drugs and hormones.
research Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
Suppressing eIF4E can prevent hair loss from chemotherapy.
research Chitosan Nanoparticles for Topical Drug Delivery in Chemotherapy-Induced Alopecia: A Comparative Study of Five Repurposed Pharmacological Agents
Phenobarbital-loaded chitosan nanoparticles are promising for preventing hair loss from chemotherapy.
research New Plant Extracts Exert Complementary Anti‐Hair Loss Properties in Human In Vitro and Ex Vivo Models
The plant extracts may help treat hair loss by promoting hair growth and reducing DHT levels.
research Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles
Human hair follicles can provide stem cells for regenerative medicine.
research Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
Inhibiting Bmp signaling disrupts hair growth and differentiation.
research Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells
Stress can cause hair to turn gray by depleting stem cells.