January 2026 in “Advanced Science” The study explores the role of DDRGK1-mediated ER-phagy in noise-induced hearing loss (NIHL), revealing that ER-phagy is crucial for maintaining ER homeostasis and cell survival. It was found that noise exposure decreases XIAP and DDRGK1 protein levels, inhibiting ER-phagy. XIAP binds to DDRGK1, enhancing its stability and activating ER-phagy. In noise-exposed CBA/CaJ mice, gastrodin, a traditional Chinese medicine ingredient, mitigates cochlear hair cell loss, synaptic damage, and hearing loss by promoting XIAP expression, which increases DDRGK1 levels and activates ER-phagy. These results suggest that targeting XIAP-DDRGK1-mediated ER-phagy could be a novel therapeutic approach for treating NIHL.
21 citations
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December 1994 in “Journal of Investigative Dermatology” November 2025 in “Advanced Science” A new nanozyme using EGCG and L-arginine boosts hair growth by safely increasing beneficial oxidative stress.
March 2024 in “International journal of molecular sciences” Three specific genetic variants cause severe skin issues in children with EBS, highlighting the need for early genetic screening.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Stress in hair follicle cells increases certain immune-related proteins, which might contribute to hair loss conditions.
Plakophilin 1 helps control skin cell immune responses to prevent excessive inflammation.
UBC13 and UBC22 enzymes are important for plant growth and development in Arabidopsis thaliana.
13 citations
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February 2007 in “British Journal of Dermatology” EF and PXE not closely related.
7 citations
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October 2018 in “BMC genomics” Key genes can rewire networks, changing skin appendage types.
5 citations
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April 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” A new therapy for a skin blistering condition has not been developed yet.
10 citations
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February 2019 in “Journal of Cellular Biochemistry” Specific RNA patterns are linked to alopecia areata.
5 citations
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January 2011 in “Archives de Pédiatrie” A severe form of Netherton syndrome caused by a specific gene mutation led to neonatal deaths in a family.
3 citations
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April 2021 in “Biomolecules & Therapeutics” The protein ER71/ETV2 helps regrow hair after chemotherapy by improving the growth of new blood vessels.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” New RIPK4 gene mutations were found to cause a type of skin and limb birth defect.
1 citations
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October 2018 in “PubMed” EK significantly improved wound healing and reduced infection in burn wounds.
February 2013 in “Journal of the American Academy of Dermatology” Certain gene variations might increase the risk of a hair loss condition in Koreans.
1 citations
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December 2016 in “Revista română de medicină de laborator” The NIPAL4 mutation c.527C>A is common in Romanian patients with autosomal recessive congenital ichthyosis.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” ARQ-234, a protein designed to treat atopic dermatitis, shows increased effectiveness in early testing.
2 citations
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August 2025 in “Pharmaceutics” PN hydrates skin; PDRN heals and regenerates skin and hair.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” Double-stranded RNA helps regenerate hair follicles by increasing retinoic acid production and signaling.
1 citations
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January 2020 in “Benha Journal of Applied Sciences” Certain gene variations may increase the risk and severity of alopecia areata.
November 2022 in “Journal of Investigative Dermatology” Scientists found a new type of skin cell that could help with skin repair and these cells work better with a certain protein.
1 citations
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January 2025 in “Journal of Fungi” Erythema nodosum linked to kerion can be treated effectively with antifungals and steroids to reduce scarring.
April 2023 in “Journal of Investigative Dermatology” RNase L suppresses regeneration in mammals.
November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Dermal EZH2 controls skin cell growth and differentiation in mice.
4 citations
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April 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” Krt16-deficient mice help understand skin disorders like PC and FNEPPK.
1 citations
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April 2018 in “Journal of Investigative Dermatology” PRC1 is essential for proper skin development and stem cell formation by controlling gene activity.
13 citations
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July 2016 in “Indian Journal of Dermatology” DPR can show different hair characteristics, as seen in two brothers with normal hair.
April 2024 in “Anais Brasileiros de Dermatologia” 15 citations
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August 2022 in “The Application of Clinical Genetics” ABCD1 gene mutations cause adrenomyeloneuropathy, leading to symptoms like limb weakness and spasticity, with management focusing on rehabilitation and spasticity treatment.