10 citations
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September 2018 in “Regenerative Medicine” New hair can grow from large wounds in mice, but less so as they age, involving reprogramming of skin cells and specific molecular pathways.
387 citations
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November 2003 in “Journal of Investigative Dermatology” The K15 promoter effectively targets stem cells in the hair follicle bulge.
36 citations
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July 2014 in “Experimental Dermatology” Skin and hair can regenerate after injury due to changes in gene activity, with potential links to how cancer spreads. Future research should focus on how new hair follicles form and the processes that trigger their creation.
14 citations
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January 2019 in “Advances in experimental medicine and biology” Skin stem cells are promising for healing wounds and skin regeneration due to their accessibility and regenerative abilities.
April 2018 in “Journal of Investigative Dermatology” The research found that a specific skin cell type not only triggers hair growth but also controls hair color, and that aging can lead to hair loss and color changes.
January 2008 in “The Year book of dermatology” After skin injury, adult mice can grow new hair follicles, and this process can be increased or stopped by manipulating Wnt signals.
5 citations
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January 2023 in “Cell proliferation” Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.
16 citations
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March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.
1 citations
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October 2022 in “JCI insight” Deleting the BRD4 protein in certain skin cells causes hair loss and skin inflammation.
555 citations
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July 2001 in “Genes & Development” Tcf3 and Lef1 are key in deciding skin stem cell roles.
118 citations
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January 2016 in “Current Topics in Developmental Biology” The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.
25 citations
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May 2020 in “EMBO reports” Calcium is important for stem cell function and maintenance, especially in blood and skin cells.
16 citations
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September 2019 in “Journal of biological chemistry/The Journal of biological chemistry” Mice without certain skin enzymes have faster hair growth and bigger eye glands.
January 2012 in “Durham e-Theses (Durham University)” Keratin 15 affects cell behavior and characteristics in skin cells.
The new biomimetic skin heals wounds faster and better than traditional treatments, without scarring.
72 citations
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November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
30 citations
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November 2018 in “EMBO Reports” The Ovol2-Zeb1 circuit is crucial for skin healing and hair growth by guiding cell movement and growth.
4 citations
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July 2022 in “Annals of translational medicine” Scientists created complete hair-like structures by growing mouse skin cells together in a special gel.
1 citations
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April 2016 in “CRC Press eBooks” Skin aging reflects overall body aging and can indicate internal health conditions.
1 citations
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January 2016 in “Elsevier eBooks” The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.
37 citations
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January 2022 in “Frontiers in Genetics” Aging reduces dermal sheath cells, affecting youthful skin appearance.
8 citations
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April 2017 in “Journal of Dermatological Science” Hair loss is caused by the breakdown of a protein called COL17A1 in hair follicle stem cells.
3 citations
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November 2011 in “Small GTPases” Researchers found that hair follicle stem cells can become squamous cell carcinoma due to Ras activation, which could lead to new treatments.
April 2021 in “Journal of Investigative Dermatology” Bacteria can help skin regenerate through a process called IL-1β signaling.
April 2017 in “Journal of Investigative Dermatology” Blocking JAK-STAT5 signaling in mice leads to hair growth.
May 2023 in “International journal of molecular sciences” The ABCA4 gene protects hair follicle stem cells from toxic vitamin A byproducts.
16 citations
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August 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” MED1 is essential for normal hair growth and maintaining hair follicle stem cells.
28 citations
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May 2012 in “Veterinary Dermatology” Different types of dog hair loss are linked to problems starting the hair growth phase and early hair cycle ending.
1 citations
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September 2015 in “Elsevier eBooks” SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.
May 2014 in “Journal of Investigative Dermatology” Scientists developed tools to observe hair regeneration in real time and assess skin health, using glowing mice and light-controlled genes.