research Keratin intermediate filaments in the colon: guardians of epithelial homeostasis
Keratin proteins are essential for keeping the cells in the human colon healthy and stable.
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research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix
CIP/KIP proteins help stop cell division and support hair growth.
research The protease corin regulates electrolyte homeostasis in eccrine sweat glands
Corin helps control salt and sweat release in sweat glands.
research Organizational principles of integumentary organs: Maximizing variations for effective adaptation
Integumentary organs adapt and evolve for survival, with potential uses in regenerative medicine.
research Functional ectodermal organ regeneration as the next generation of organ replacement therapy
The document concludes that regenerating functional ectodermal organs like teeth and hair is promising for future therapies.
research Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates
Newly divided skin cells quickly move to join skin structures due to tissue tension and specific signals.
research The thrill of scientific discovery and leadership with my group
The author felt excited and honored to receive the 2016 Early Career Life Scientist Award.
research The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice
ARHGEF3 is essential for proper hair follicle development in mice.
research Convergent evolution has led to the loss of claw proteins in snakes and worm lizards
Snakes and worm lizards lost claw proteins due to similar evolutionary changes.
research DNMT1 targets SRD5A2 to induce mitochondrial homeostasis and EMT in urothelial cells of hypospadias
DNMT1 may help treat hypospadias by improving cell function and preventing unwanted cell changes.
research Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells
Macrophages help activate hair follicle stem cells, affecting hair growth and skin repair.
research Tracing the cellular origin of cancer
Understanding where cancer cells come from helps create better prevention and treatment methods.
research Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer
A specific chemical change in the S100A3 protein leads to the formation of a four-part structure important for hair formation.
research The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties
Keratin 19 forms less stable and shorter filaments than keratin 14, giving unique traits to certain skin cells.
research Neuregulin3 alters cell fate in the epidermis and mammary gland
Neuregulin3 affects cell development in the skin and mammary glands.
research Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin
Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.
research Severe Abnormalities in the Oral Mucosa Induced by Suprabasal Expression of Epidermal Keratin K10 in Transgenic Mice
Abnormal keratin expression in mice causes severe oral issues, affecting feeding.
research Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression
A specific signal from hair cells controls the tightening of the surrounding muscle, which is necessary for hair shedding.
research Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture
Mechanical forces are crucial for shaping cells and forming tissues during development.
research Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics
Removing Mediator 1 from certain mouse cells causes teeth to grow hair instead of enamel.
research Wound Healing Induced Hair Follicle Regeneration
New hair can grow at wound sites, which could help improve treatments for hair loss and wound healing.
research Hair curvature: a natural dialectic and review
The document concludes that hair curvature can be explained by the growth patterns caused by the shape and separation of cells in the hair follicle and is affected by specific molecular pathways.
research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.
Hair and nail cells share similar proteins, indicating a common differentiation pathway.
research Types I and II Keratin Intermediate Filaments
Keratins are crucial for cell structure, growth, and disease risk.
research Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation.
Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.
research Hair follicle stem cells: Walking the maze
Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.
research Early inductive events in ectodermal appendage morphogenesis
Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.
research Mouse notch: expression in hair follicles correlates with cell fate determination.
Mouse Notch is important for determining cell roles in hair follicles.
research Stem cell dynamics in the hair follicle niche
Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.
research Chapter 2 The Human Keratin Genes and Their Differential Expression
Different keratin proteins are expressed in various epithelial cells at different stages, affecting cell structure and function.