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GlossaryEpithelial Cell Proliferation

process where cells lining organs multiply and increase

Epithelial cell proliferation refers to the process by which epithelial cells, which are the cells that line the surfaces of organs and structures in the body, multiply and increase in number. This process is crucial for wound healing, tissue regeneration, and maintaining the integrity of barriers like the skin and the lining of the gut. For professionals, understanding this process is essential for developing treatments for conditions like cancer, where cell proliferation is uncontrolled, or for promoting healing in injuries and surgeries.

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The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization, and Hair Growth in a Porcine Model

research The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model

16 citations , April 2016 in “PLoS ONE”

Negative pressure treatment improved skin thickness, blood vessel growth, and hair growth.

research 1458 EMT-inhibiting transcription factor Ovol2 regulates directional cell migration and proliferation in adult skin epithelia

April 2018 in “Journal of Investigative Dermatology”

Ovol2 is important for proper skin healing and hair growth.

research β1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis and Migration of Their Progeny

20 citations , December 2013 in “PLoS ONE”

β1 integrin is essential for the survival, growth, and movement of human epithelial progenitor cells.

research Dihydroartemisinin attenuates benign prostatic hyperplasia in rats by inhibiting prostatic epithelial cell proliferation

4 citations , August 2021 in “Annals of Translational Medicine”

Dihydroartemisinin helps reduce prostate enlargement in rats by stopping the growth of prostate cells.

research Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells

45 citations , September 2001 in “Journal of Investigative Dermatology”

Cyclosporin A promotes hair cell growth and affects protein kinase C levels.

research Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity

24 citations , July 2018 in “Stem cells”

Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research Pigment epithelium‑derived factor short peptides facilitate full‑thickness cutaneous wound healing by promoting epithelial basal cell and hair follicle stem cell proliferation

6 citations , September 2017 in “Experimental and Therapeutic Medicine”

Shortened PEDF peptides speed up skin wound healing by boosting cell growth.

Wnt7a Can Up-Regulate Cell Adhesion Related Protein Fibronectin Expression and Promote Cell Proliferation in Corneal Epithelial Cells

research Wnt7a can up-regulates cell adhesion related protein fibronectin expression and promotes cell proliferation in corneal epithelial cells

April 2023

Wnt7a helps corneal cells grow and stick together, aiding in repair.

research The Krüppel-like Factor Epiprofin Is Expressed by Epithelium of Developing Teeth, Hair Follicles, and Limb Buds and Promotes Cell Proliferation

88 citations , December 2003 in “Journal of Biological Chemistry”

Epiprofin helps cells grow in developing teeth, hair, and limbs.

research hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

3 citations , December 2023 in “Aging”

hsa_circ_0002980 can help stop liver cancer cells from growing and spreading.

research Macrophage ferroportin is essential for stromal cell proliferation in wound healing

45 citations , August 2018 in “Haematologica”

Macrophage iron release is crucial for hair growth and wound healing.

research An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation

30 citations , November 2018 in “EMBO Reports”

The Ovol2-Zeb1 circuit is crucial for skin healing and hair growth by guiding cell movement and growth.

research Hair growth inhibition by heparin in mice: a model system for studying the modulation of epithelial cell growth by glycosaminoglycans?

46 citations , May 1991 in “British Journal of Dermatology”

Heparin can inhibit hair growth in mice when injected.

research Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth

124 citations , December 1983 in “Developmental Biology”

EGF receptors are crucial for skin cell growth and decrease with age.

research Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

80 citations , April 2018 in “Trends in Molecular Medicine”

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

research Biological actions of oligomeric procyanidins: Proliferation of epithelial cells and hair follicle growth

8 citations , January 2001 in “Methods in enzymology on CD-ROM/Methods in enzymology”

Oligomeric procyanidins may help hair grow by affecting cell growth and the hair growth cycle.

research 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification

1 citations , April 2018 in “Journal of Investigative Dermatology”

PRC1 is essential for proper skin development and stem cell formation by controlling gene activity.

research Stereological Quantification of Cell-Cycle Kinetics and Mobilization of Epithelial Stem Cells during Wound Healing

1 citations , January 2016 in “Methods in molecular biology”

The method helps estimate and track skin cell growth and movement during healing.

research Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris

71 citations , October 2017 in “Journal of Investigative Dermatology”

PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.

research 621 An apple stem cell-derived extract increases epithelial stem cells number in the hair follicle bulge

September 2019 in “Journal of Investigative Dermatology”

Apple stem cell extract may increase the number of stem cells in a part of the hair follicle.

research Local Microenvironment Provides Important Cues for Cell Differentiation in Lingual Epithelia

6 citations , April 2012 in “PloS one”

The local environment is crucial for cell development in the tongue.

research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions

61 citations , July 2011 in “PLOS ONE”

Spermidine may help reduce hair loss and deserves further testing as a treatment.

research Injury suppresses Ras cell competitive advantage through enhanced wild-type cell proliferation

1 citations , January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Injury boosts normal skin cell growth, reducing cancer cell advantage.

research Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer

13 citations , September 2019 in “EBioMedicine”

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

ERK1/2 Pathway Involvement in Enhancement of Fatty Acids from Phaeodactylum Tricornutum Extract on Hair Follicle Cell Proliferation

research ERK1/2 Pathway Is Involved in the Enhancement of Fatty Acids from Phaeodactylum tricornutum Extract (PTE) on Hair Follicle Cell Proliferation

2 citations , January 2020 in “BioMed Research International”

Phaeodactylum tricornutum extract helps hair follicle cells grow by activating the ERK1/2 pathway.

Improvement of Androgenetic Alopecia with Topical Sophora Flavescens Aiton Extract, and Identification of the Two Active Compounds in the Extract That Stimulate Proliferation of Human Hair Keratinocytes

research Improvement of androgenetic alopecia with topicalSophora flavescensAiton extract, and identification of the two active compounds in the extract that stimulate proliferation of human hair keratinocytes

11 citations , October 2015 in “Clinical and Experimental Dermatology”

Sophora flavescens extract helps hair growth and treats hair loss.

research The HPV16 oncogenes cause aberrant stem cell mobilization

23 citations , May 2013 in “Virology”

HPV16 oncogenes disrupt the normal activity of hair follicle stem cells.

research Runx Family Genes in Tissue Stem Cell Dynamics

6 citations , January 2017 in “Advances in Experimental Medicine and Biology”

Runx genes are important for stem cell regulation and their roles in aging and disease need more research.

The Pathological Changes and Polymorphonuclear and Mast Cell Responses in the Skin of Specific Pathogen-Free Lambs Following Primary and Secondary Challenge with Orf Virus

research The Pathological Changes and Polymorphonuclear and Mast Cell Responses in the Skin of Specific Pathogen‐free Lambs Following Primary and Secondary Challenge with Orf Virus

18 citations , September 1990 in “Veterinary Dermatology”

Lambs' skin showed similar but more severe responses to a second orf virus infection, involving immune cells and new skin formation.