125 citations
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September 2019 in “Journal of Clinical Immunology” Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.
27 citations
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May 2007 in “Archives of dermatological research” Diphencyprone treatment increases CD8 lymphocytes in the scalp, which is associated with hair regrowth in alopecia areata patients.
7 citations
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March 2012 in “Journal of Investigative Dermatology” Some thymic peptides can increase human hair growth, while others may inhibit it.
3 citations
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September 2019 in “Clinical and experimental dermatology” Basal cell carcinomas may differentiate similarly to hair follicles and could be influenced by hair cycle-related treatments.
788 citations
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February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
222 citations
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October 2014 in “Annual Review of Pharmacology and Toxicology” Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.
176 citations
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January 2003 in “Journal of Investigative Dermatology” Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.
150 citations
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October 2010 in “The American Journal of Pathology” The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.
150 citations
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August 1992 in “Genes & Development” TNF alpha in skin cells causes weight loss, hair and fat issues, and skin inflammation in mice.
149 citations
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July 2017 in “PLoS Biology” Hair follicle patterns form through a mix of self-organization and signaling interactions.
112 citations
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January 2014 in “Molecular and cellular therapies” Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.
89 citations
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January 2009 in “Advances in Clinical Chemistry” Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.
86 citations
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April 2016 in “Nature Communications” Notch1 helps skin heal by attracting specific immune cells.
86 citations
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October 2005 in “Experimental Dermatology” The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
85 citations
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October 2006 in “Current opinion in cell biology” Feather growth and regeneration involve complex patterns, stem cells, and evolutionary insights.
82 citations
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October 2019 in “Frontiers in Immunology” Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.
81 citations
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October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology” Certain genes control the color of human hair by affecting pigment production.
81 citations
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January 2003 in “The FASEB Journal” Follistatin helps hair growth and cycling, while activin prevents it.
66 citations
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August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
59 citations
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March 2020 in “Journal of Biomedical Science” Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.
52 citations
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September 2020 in “Cell Death and Disease” Overactive sonic hedgehog signaling worsens uterine scarring by reducing cell recycling.
46 citations
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March 2019 in “Journal of Pineal Research” Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.
45 citations
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February 2018 in “Journal of basic and clinical physiology and pharmacology/Journal of basic & clinical physiology & pharmacology” *Acorus calamus* has many medicinal benefits but needs more safety research.
42 citations
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January 2014 in “Cold Spring Harbor Perspectives in Medicine” Hair growth is influenced by various body and external factors, and neighboring hairs communicate to synchronize regeneration.
37 citations
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September 2018 in “Psychoneuroendocrinology” Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.
35 citations
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July 2018 in “Cell Reports” The study found that a specific area of the hair follicle helps start hair growth by reducing the blocking effects on certain cells and controlling growth signals.
31 citations
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February 2019 in “International Journal of Cosmetic Science” Caffeine applied to the scalp can protect hair follicles from UV damage.
30 citations
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December 2018 in “Trends in Endocrinology and Metabolism” Both immature and mature fat cells are important for hair growth cycles, with immature cells promoting growth and mature cells possibly inhibiting it.
29 citations
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July 2014 in “PLoS ONE” Inactivating β-catenin is essential for chick retina regeneration.
27 citations
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March 2024 in “Frontiers in Pharmacology” Natural products can help overcome cancer drug resistance.