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research Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways

30 citations , December 2021 in “Frontiers in Microbiology”

Cepharanthine effectively reduces Herpes Simplex Virus Type 1 by blocking certain cell pathways and promoting cell death.

research Anthracycline analogs The past, present, and future

168 citations , December 1986 in “Cancer Chemotherapy and Pharmacology”

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

research Steroid 5α-Reductase Inhibitors

42 citations , May 2003 in “Mini-reviews in Medicinal Chemistry”

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

research ChemInform Abstract: Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α‐Reductase Inhibitor.

April 2011 in “ChemInform”

A new compound may effectively inhibit the enzyme linked to BPH and hair loss.

Cyproterone Acetate for Topical Treatment of Androgen-Dependent Diseases

research Cyproteronacetat zur topischen Therapie androgenabhängiger Erkrankungen

January 2006

Cyproterone acetate is used for topical treatment of diseases dependent on male hormones.

research Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives as dual 5α-reductase inhibitors and androgen receptor antagonists

3 citations , May 2017 in “Bioorganic & medicinal chemistry letters”

New compounds were made that are promising for prostate cancer therapy.

Computational Screening of Repurposed Drugs and Natural Products Against SARS-CoV-2 Main Protease as Potential COVID-19 Therapies

research Computational screening of repurposed drugs and natural products against SARS-Cov-2 main protease (Mpro) as potential COVID-19 therapies

September 2020 in “arXiv (Cornell University)”

Some existing drugs and natural products might work against COVID-19 by targeting the virus's main protease.

research Pharmacology of antiandrogens

97 citations , November 1986 in “Journal of Steroid Biochemistry”

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

research Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

18 citations , December 2005 in “Journal of Medicinal Chemistry”

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

research The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.

44 citations , May 1998 in “PubMed”

The retinoid receptor antagonist effectively disrupts vitamin A-related development in embryos.

research First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours.

33 citations , May 2017 in “Journal of Clinical Oncology”

ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.

research A combination of low-dose systemic etretinate and topical calcipotriol/betamethasone dipropionate treatment for hyperkeratosis and itching in Olmsted syndrome associated with a TRPV3 mutation

5 citations , May 2017 in “Journal of dermatological science”

The combined treatment effectively managed severe skin issues in Olmsted syndrome.

research 5α-reduced progestogens ameliorate mood-related behavioral pathology, neurotoxicity, and microgliosis associated with exposure to HIV-1 Tat

47 citations , January 2016 in “Brain Behavior and Immunity”

5α-reduced progestogens may reduce mood issues and brain damage linked to HIV-1 Tat.

research 5alpha-reductase inhibitors/finasteride.

4 citations , January 1996 in “PubMed”

research Emerging Strategies in Smart Nano-PROTAC for Stimuli-Responsive Protein Degradation and Precision Cancer Therapy

6 citations , June 2025 in “Nano Biomedicine and Engineering”

Smart nano-PROTACs improve cancer treatment by targeting proteins more precisely and reducing side effects.

research Charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping

10 citations , November 2017 in “Letters in drug design & discovery”

Researchers identified promising inhibitors for the BRD4 protein, including finasteride and amentoflavone.

research New potential chemotherapy for ovarian cancer — Combined therapy with WP 631 and epothilone B

12 citations , March 2016 in “Life Sciences”

The new chemotherapy combination of WP 631 and Epothilone B shows enhanced effectiveness against ovarian cancer but requires more research on its safety.

research The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor

16 citations , August 2021 in “Tumor Biology”

TMPRSS2 helps viruses enter cells and protects the prostate from inflammation-related cancer.

Prostaglandin E2 Prevents Radiotherapy-Induced Alopecia by Attenuating Transit Amplifying Cell Apoptosis Through Promoting G1 Arrest

research 1503 Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Prostaglandin E2 helps prevent hair loss from radiotherapy by protecting hair growth cells and aiding self-repair.

research Both Retinoic Acid Receptors α (RARα) and γ (RARγ) Are Able to Initiate Mouse Upper-Lip Skin Glandular Metaplasia

10 citations , August 1998 in “Journal of Investigative Dermatology”

research Optimizing finasteride chemoprevention

April 2010 in “Nature Reviews Urology”

research Effect of a novel steroid (PM-9) on the inhibition of 5α-reductase present in Penicillium crustosum broths

22 citations , March 2003 in “Steroids”

PM-9 and finasteride effectively inhibit the enzyme that converts testosterone to DHT.

research Preliminary toxicity profile of arotinoids SMR-2 and SMR-6 in male B6D2F1 mice*1

15 citations , May 1987 in “Fundamental and applied toxicology”

SMR-2 and SMR-6 are much more toxic than retinoic acid, causing severe side effects.

research Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest

November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Prostaglandin E2 helps prevent hair loss from radiotherapy by protecting hair cells.

research 566 Staphylococcus epidermidis for the topical treatment of epidermal growth factor receptor (EGFR) inhibitor-induced dermal toxicity

July 2024 in “Journal of Investigative Dermatology”

ATR04-484 ointment shows promise for treating skin issues from cancer therapies.

research finasteride, n.

March 2023 in “Oxford University Press eBooks”

research The antiviral activity of a small molecule drug targeting the NSP1-ribosome complex against Omicron, especially in elderly patients

6 citations , March 2023 in “Frontiers in Cellular and Infection Microbiology”

Golvatinib shows promise as a treatment for Omicron in elderly patients.

research EFFECT OF "AMINOPTERIN" ON EPITHELIAL TISSUES

3 citations , June 1983 in “Archives of Dermatology”

Aminopterin effectively improves skin conditions but has toxic side effects that need careful monitoring.

research Preliminary Toxicity Profile of Arotinoids SMR-2 and SMR-6 in Male B6D2F1 Mice

January 1987 in “Toxicological sciences”

SMR-2 and SMR-6 are much more toxic than retinoic acid, causing severe symptoms and organ damage in mice.

research AB032. Development of new treatment modality for male infertility by using phytopharmaceuticals

September 2018 in “Translational andrology and urology”

MOTILIPERM may help treat male infertility by reducing stress in cells.

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