research Determination of Exemestane in Human Plasma by LC-MS-MS
The method effectively showed that the two exemestane preparations are bioequivalent.
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research Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor.
Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.
research Rapid and Sensitive LC–MS–MS Method for the Simultaneous Estimation of Alfuzosin and Dutasteride in Human Plasma
A fast and accurate method was developed to measure alfuzosin and dutasteride in human plasma.
research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles
The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.
research Rapid Blood Pressure Control With Minoxidil
Minoxidil effectively lowers blood pressure and initially increases plasma renin activity without raising aldosterone levels.
research A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function
Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.
research Determination of finasteride in human plasma by liquid chromatography–electrospray ionization tandem mass spectrometry with flow rate gradient
Researchers developed a quick and sensitive way to measure finasteride in blood using a small sample size.
research STABILITY-INDICATING MICELLAR ELEKTROKINETIC CHROMATOGRAPHY METHOD FOR DETERMINATION OF FINASTERIDE IN PHARMACEUTICAL PREPARATIONS
Method accurately measures finasteride concentration in medicine.
research Impact of Ester Promoieties on Transdermal Delivery of Ketorolac
Balancing lipophilicity and solubility is key for effective and safe ketorolac prodrugs.
research Optimization of LC method for the determination of testosterone and epitestosterone in urine samples in view of biomedical studies and anti-doping research studies
Researchers developed a reliable method to measure testosterone and epitestosterone in urine for medical and anti-doping use.
research LB1076 Using the frog embryonic epidermis as a model to study desmosome function during development
Frog skin cells need the protein desmoplakin for proper development and cell layer formation.
research Selective inhibition of glucuronidation and sulfation in vitro and in vivo
research In vitro biotransformation of finasteride in rat hepatic microsomes. Isolation and characterization of metabolites.
research Disposition and metabolism of finasteride in dogs.
research Determination of finasteride and its metabolite in urine by dispersive liquid–liquid microextraction combined with field-enhanced sample stacking and sweeping
New method accurately measures finasteride and M3 in urine, helping evaluate pharmacokinetics.
research Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry. Application to a Comparative Pharmacokinetics Study
New method measures finasteride in plasma, finds two formulations bioequivalent.
research Pharmacokinetics and Bioequivalence of Finasteride Tablets in Healthy Subjects
The two finasteride tablet formulations are bioequivalent.
research A regulatory perspective on pharmacokinetic/pharmacodynamic modelling
The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.
research Saturable Binding of Finasteride to Steroid 5α-reductase as Determinant of Nonlinear Pharmacokinetics
Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.
research Determination of finasteride in healthy volunteers by optimized liquid chromatography-tandem spectrometry
The method accurately measures finasteride levels in the body.
research Screening and confirmation methods of the major urinary metabolite of finasteride–carboxy-finasteride by liquid chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry
New methods can detect finasteride's major urinary metabolite in urine for up to 49 hours.
research Percutaneous Absorption of Minoxidil in Man
Minoxidil absorbs poorly through skin, with low risk of side effects at 1-2% concentration.
research Determination of finasteride in human plasma by LC-MS and its pharmacokinetics
The method accurately measures finasteride in plasma, and the test tablets are as effective as the reference ones.
research Selective and rapid determination of tadalafil and finasteride using solid phase extraction by high performance liquid chromatography and tandem mass spectrometry
Quick, selective detection of tadalafil and finasteride in human plasma developed.
research Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry
The method effectively measures drug impact on DHT levels in prostate treatments.
research Evaluation of glucuronide metabolite stability in dried blood spots
Dried blood spots can be as stable as frozen liquid samples for storing certain metabolites.
research Diseases of Hair and Nails
The document says that there are treatments for hair and nail diseases.
research Miscellaneous Steroids
The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.
research Determination the Dissolution of Finasteride Tablets by HPLC
The method accurately measures finasteride tablet dissolution.
research BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FINASTERIDE, TADALAFIL, AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN RAT PLASMA BY USING LC-MS/MS
A reliable method was developed to measure Finasteride and Tadalafil in rat blood.