January 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Newly born mesenchymal cells quickly spread out in response to tissue tension during early development.
359 citations
,
January 2015 in “Cold Spring Harbor Perspectives in Medicine” Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
93 citations
,
June 2011 in “Journal of Neuroscience” p63 is essential for activating and differentiating stem cells in the nose's olfactory tissue.
57 citations
,
December 2021 in “Nature Communications” Non-canonical Wnt signaling helps intestinal stem cells move to injury sites for tissue repair.
9 citations
,
April 2025 in “International Journal of Nanomedicine” An injectable ibuprofen gel speeds up diabetic wound healing by reducing inflammation and promoting tissue growth.
9 citations
,
April 2019 in “International Journal of Molecular Sciences” Kojyl cinnamate ester derivatives can promote hair growth by increasing adiponectin production in fat tissues.
24 citations
,
April 2017 in “Oncology Reports” The hair keratin gene KRT81 is found in both normal and breast cancer cells and helps them invade surrounding tissues.
52 citations
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October 1999 in “Developmental Dynamics” Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.
April 2024 in “Exploratory Animal and Medical Research” Sarcoptes mites cause severe skin issues in dogs, which can be fatal if untreated.
291 citations
,
April 2010 in “Gastroenterology” Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.
34 citations
,
June 2014 in “The BMJ” Pregnancy can change skin disease severity, with some conditions improving and others worsening, and treatment should balance benefits and fetal safety.
10 citations
,
October 2020 in “Frontiers in Cell and Developmental Biology” Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
2 citations
,
May 2017 in “Springer eBooks” Pregnancy can cause skin changes and affect existing skin conditions, with limited treatment options due to the need for fetal safety.
1 citations
,
January 2024 in “Advances in Engineering Technology Research” Bone marrow stem cells from Guizhou miniature pigs can grow well and become different cell types, useful for tissue engineering.
March 2011 in “Journal of clinical and experimental investigations” Thallium poisoning can cause hair loss, skin rashes, and nerve damage, and can be fatal if not correctly diagnosed and treated.
November 2008 in “Medical & surgical dermatology” A device was made in 2008 to measure hair loss severity. Other findings include: frizzy mutation in mice isn't related to Fgfr2, C/EBPx marks preadipocytes, Cyclosporin A speeds up hair growth in mice, blocking plasmin and metalloproteinases hinders healing, hyperbaric oxygen helps ischemic wound healing, amniotic membranes heal wounds better than polyurethane foam, rhVEGF165 from a fibrin matrix improves tissue flap viability and induces VEGF-R2 expression, and bFGF enhances wound healing and reduces scarring in rabbits.
5 citations
,
December 2018 in “Frontiers in Endocrinology” Differences in androgen receptor expression and tissue properties may lead to higher cryptorchidism risk in certain rats.
80 citations
,
January 2020 in “Journal of Nanobiotechnology” Nanomaterials can aid tissue repair and healing but need more safety research.
39 citations
,
August 2017 in “Annual Review of Genetics” Understanding tissue regeneration in animals can improve regenerative medicine.
36 citations
,
April 2013 in “Cell and Tissue Research” Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” Double-stranded RNA helps regenerate hair follicles by increasing retinoic acid production and signaling.
52 citations
,
August 2021 in “Microorganisms” Higher ACE2 levels in certain tissues may worsen COVID-19 in people with other health issues, especially older adults.
13 citations
,
September 2014 in “BMC Complementary and Alternative Medicine” Tanshinone IIA helps protect skin tissue from low oxygen damage by boosting certain cell markers.
6 citations
,
October 2014 in “International Journal of Molecular Sciences” Tanshinone IIA helps protect tissue from low oxygen damage by activating certain cell pathways.
3 citations
,
January 2023 in “Journal of Hard Tissue Biology” Wnt10a may help regenerate dental pulp and form dentine.
May 2025 in “Frontiers in Immunology” Autoimmune diseases with high tissue recovery often relapse and remit, while those with low recovery rarely remit.
52 citations
,
January 2023 in “Annual Review of Immunology” Immune-epithelial interactions are crucial for tissue repair, but unchecked can cause diseases.
1036 citations
,
August 2019 in “Cells” Mesenchymal stem cells can help repair body tissues with low risk of rejection.
11 citations
,
July 2024 in “Biomimetics” Injectable biomimetic gels can help heal tissues and deliver drugs but need improvements in strength and delivery.
6 citations
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June 2024 in “Gels” 5% hydroxyapatite in scaffolds improves bone tissue formation and mechanical properties.