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GlossaryFibroblast Growth Factor

promotes cell growth, tissue repair, and development

Fibroblast Growth Factor (FGF) is a family of proteins that play a crucial role in cell growth, tissue repair, and development. One well-known member, FGF-2 or Basic Fibroblast Growth Factor (bFGF), is particularly important for promoting the proliferation and differentiation of cells, including those involved in hair growth and wound healing.

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research Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats’ Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

2 citations , July 2023 in “Animals”

FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.

Branching of Spiral Ganglion Neurites Induced by Focal Application of Fibroblast Growth Factor-1

research Branching of Spiral Ganglion Neurites Is Induced by Focal Application of Fibroblast Growth Factor‐1

15 citations , May 2003 in “The Laryngoscope”

FGF-1 causes spiral ganglion neurites to branch more.

Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum Copticum Seeds

research Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds

August 2018

Ajwain seed extract improved skin healing and hair growth in a mouse skin irritation model.

research Expression of bioactive recombinant human fibroblast growth factor 10 in Carthamus tinctorius L. seeds

20 citations , September 2015 in “Protein expression and purification”

Scientists made safflower seeds produce a human growth factor that could help with hair growth and wound healing.

Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice

research Fibroblast Growth Factors Stimulate Hair Growth throughβ-Catenin and Shh Expression in C57BL/6 Mice

64 citations , January 2015 in “BioMed Research International”

Certain growth factors can promote hair growth in mice by activating hair growth-related proteins.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts

20 citations , January 2019 in “Journal of dermatological science”

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

Dermal Fibroblasts Enhance Growth Factors Production by Androgens and Modulate Keratinocyte Proliferation and Differentiation

research 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Androgens increase growth factors in skin cells, which may lead to acne.

Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

research Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats

42 citations , September 2015 in “Gene”

FGF5s can block the effects of FGF5, which may help control hair growth in cashmere goats.

research Suppression of Cutibacterium acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin

7 citations , March 2022 in “International Journal of Molecular Sciences”

FGF21 can help reduce skin inflammation caused by C. acnes.

In Vitro Effects of the Phytocomplex TrichoTech on Human Fibroblasts: Proliferative Potential and Effects on Gene Expression of FGF-7 and FGF-10

research In <i>Vitro</i> Effects of the Phytocomplex TrichoTech<sup>TM</sup> on Human Fibroblasts: Proliferative Potential and Effects on Gene Expression of FGF-7 and FGF-10

2 citations , January 2017 in “Journal of Cosmetics, Dermatological Sciences and Applications”

TrichoTech™ may help hair growth and skin repair by increasing fibroblast growth and activity.

research 730 M2 macrophages promote wound induced hair neogenesis through the production of growth factors

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

M2 macrophages help hair regrowth in wounds by making growth factors.

research Effects of FGF5-mediated LncRNA on the skin fibroblast growth of Liaoning Cashmere goats

July 2023 in “Indian Journal of Animal Health”

FGF-5 promotes Cashmere goat hair growth by increasing keratin genes and reducing certain LncRNA and target genes.

Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

research Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations , February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

research Induction of Vascular Endothelial Growth Factor Messenger Ribonucleic Acid Expression in Stored Micrografts by Aminoguanidine

3 citations , November 2005 in “Dermatologic Surgery”

Aminoguanidine increases a specific growth signal in stored hair grafts, which may help them survive better after being transplanted.

Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways

research Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways

1 citations , July 2023 in “International Journal of Molecular Sciences”

Treating fat stem cells with low oxygen boosts hair growth cell growth through specific signaling pathways.

research Induction of Vascular Endothelial Growth Factor Messenger Ribonucleic Acid Expression in Stored Micrografts by Aminoguanidine

1 citations , November 2005 in “Dermatologic Surgery”

Aminoguanidine increases VEGF in stored hair micrografts, potentially improving their viability after transplant.

research Hair growth promoting activity of discarded biocomposite keratin extract

3 citations , June 2017 in “Journal of Biomaterials Applications”

Keratin extract from human hair was found to promote hair growth in mice.

Heat-Treated Limosilactobacillus Fermentum LM1020 with Menthol, Salicylic Acid, and Panthenol Promotes Hair Growth and Regulates Scalp Microbiome Balance in Androgenetic Alopecia: A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial

research Heat‐treated Limosilactobacillus fermentumLM1020 with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double‐blind, randomized and placebo‐controlled clinical trial

May 2024 in “Journal of cosmetic dermatology”

Heat-treated Limosilactobacillus fermentum with menthol, salicylic acid, and panthenol promotes hair growth and balances scalp microbiome in people with androgenetic alopecia.

research Cucurbitacin promotes hair growth in mice by inhibiting the expression of fibroblast growth factor 18

1 citations , October 2022 in “Annals of Translational Medicine”

Cucurbitacin helps mice grow hair by blocking a protein that stops hair growth.

research The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development

125 citations , February 2007 in “The EMBO Journal”

Fgfr2b helps maintain healthy skin and prevent cancer.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

research Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

44 citations , March 2015 in “PLOS ONE”

Fibroblast Growth Factor-9 (FGF-9) can help improve heart function in diabetic mice after a heart attack by reducing inflammation and harmful changes to the heart's structure.

research Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth

19 citations , May 2016 in “Clinical, cosmetic and investigational dermatology”

FGF-2&D/P nanoparticles can help treat hair loss.

research Cashmere growth control in Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 and decorin genes

7 citations , March 2018 in “Asian-Australasian journal of animal sciences”

OCIAD2 and DCN genes affect hair growth in goats by having opposite effects on a growth signaling pathway and inhibiting each other.

Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors to Improve Skin Regeneration

research Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors To Improve Skin Regeneration

5 citations , September 2019 in “ACS Applied Bio Materials”

The hydrogel with bioactive factors improves skin healing and regeneration.

research Immunohistochemical localization of fibroblast growth factor 18 in hair follicles of healthy beagle dogs

2 citations , March 2011 in “Veterinary Dermatology”

FGF18 is present in beagle dog hair follicles, mainly in the inner root sheath.

research An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice

1 citations , December 2022 in “Current Issues in Molecular Biology”

Annurca apple extract improved hair growth in mice and could potentially prevent hair loss.

Therapeutic Effects of Growth Factor Cocktail Including Fibroblast Growth Factor 9 in Patients with Androgenetic Alopecia: A Split Study

research Therapeutic-effects-of-growth-factor-cocktail-including-fibroblast-growth-factor-9-in-patients-with-androgenetic-alopecia-a-split-study

January 2016 in “Global dermatology”

A treatment called Cellcurin, combined with microneedling, significantly increased hair density and diameter in patients with hair loss.

research Fibroblast‐derived growth factors and exosomes as cosmeceuticals

October 2023 in “Dermatological reviews”

Fibroblast-derived growth factors and exosomes can significantly improve skin aging.

research Tannic Acid Accelerates Cutaneous Wound Healing in Rats Via Activation of the ERK 1/2 Signaling Pathways

26 citations , April 2019 in “Advances in wound care”

Tannic acid helps wounds heal faster in rats by activating certain cell signals and reducing inflammation.