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GlossaryFibroblast Growth Factor

promotes cell growth, tissue repair, and development

Fibroblast Growth Factor (FGF) is a family of proteins that play a crucial role in cell growth, tissue repair, and development. One well-known member, FGF-2 or Basic Fibroblast Growth Factor (bFGF), is particularly important for promoting the proliferation and differentiation of cells, including those involved in hair growth and wound healing.

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research Radiofrequency treatment induces fibroblast growth factor 2 expression and subsequently promotes neocollagenesis and neoangiogenesis in the skin tissue

32 citations , May 2017 in “Lasers in medical science”

Radiofrequency treatment helps rejuvenate skin by boosting collagen and blood vessel growth.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

28 citations , October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

research Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth

19 citations , May 2016 in “Clinical, cosmetic and investigational dermatology”

FGF-2&D/P nanoparticles can help treat hair loss.

research Suppression of Cutibacterium acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin

7 citations , March 2022 in “International Journal of Molecular Sciences”

FGF21 can help reduce skin inflammation caused by C. acnes.

research De novo follicular regeneration of the skin by wingless int 3 and bone morphogenetic protein 2 genes introduced into dermal fibroblasts and fibroblast growth factor‐2 protein

4 citations , May 2009 in “Wound Repair and Regeneration”

Genetically modified cells can regenerate skin and hair in rats.

research Structure-guided PEGylated fibroblast growth factor 2 variants accelerate wound healing with improved stability

1 citations , May 2020

Compound 6 is a promising candidate for better wound healing.

research Fibroblast Growth Factor 21 is Differentially Expressed in Flank Skin and Regulates the Proliferation of Hair Follicle Cells in Yak

January 2025 in “SSRN Electronic Journal”

research The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development

125 citations , February 2007 in “The EMBO Journal”

Fgfr2b helps maintain healthy skin and prevent cancer.

research FC 2-2 : Therapeutic Effects of Growth Factor Cocktail (CellcurinTM) containing FGF5s (fibroblast growth factor 5 short) and NMN (nicotinamide mononucleotide) applied on the scalp in the patients with androgenetic alopecia: a split study

January 2020 in “프로그램북(구 초록집)”

The treatment increased hair growth and thickness in patients with hair loss.

research Stimulation of mouse vibrissal follicle growth by recombinant human fibroblast growth factor 20

4 citations , April 2018 in “Biotechnology Letters”

Human growth factor 20 can boost mouse whisker growth.

CRISPR/Cas9-Mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

research CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

13 citations , March 2020 in “Genes”

Disrupting the FGF5 gene in rabbits leads to longer hair by extending the hair growth phase.

Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice

research Fibroblast Growth Factors Stimulate Hair Growth throughβ-Catenin and Shh Expression in C57BL/6 Mice

64 citations , January 2015 in “BioMed Research International”

Certain growth factors can promote hair growth in mice by activating hair growth-related proteins.

research Growth factor mimetics for skin regeneration: In vitro profiling of primary human fibroblasts and keratinocytes

3 citations , May 2021 in “Archiv der Pharmazie”

SUN11602 and ONO-1301 could help in skin healing and creating artificial skin.

research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

9 citations , March 2019 in “Molecular & cellular proteomics”

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

research Enriched-GF: A Reproducible High-Yield Autologous Blood-Derived Growth Factor Method for Regenerative Medicine

March 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

The Enriched-GF method efficiently produces high-yield growth factors for tissue repair.

research 316 Role of platelet and growth factor concentration in platelet rich plasma therapeutic response to alopecia

July 2022 in “Journal of Investigative Dermatology”

High platelet numbers in PRP may not be essential for hair growth, and certain growth factors could negatively affect treatment outcomes for hair loss.

research 730 M2 macrophages promote wound induced hair neogenesis through the production of growth factors

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

M2 macrophages help hair regrowth in wounds by making growth factors.

Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

research Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations , February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

Transforming Growth Factor-β Signaling-Mediated Wound Healing Is Required for Hair Follicle Neogenesis

research 484 Transforming growth factor-β signaling-mediated wound healing is required hair follicle neogenesis

November 2024 in “Journal of Investigative Dermatology”

TGF-β signaling is essential for new hair growth after wounds.

research Cashmere growth control in Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 and decorin genes

7 citations , March 2018 in “Asian-Australasian journal of animal sciences”

OCIAD2 and DCN genes affect hair growth in goats by having opposite effects on a growth signaling pathway and inhibiting each other.

research Engineered Nanovesicles from Fibroblasts Modulate Dermal Papillae Cells In Vitro and Promote Human Hair Follicle Growth Ex Vivo

4 citations , December 2022 in “Cells”

Engineered nanovesicles from fibroblasts may help treat hair loss by promoting hair growth.

Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways

research Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways

1 citations , July 2023 in “International Journal of Molecular Sciences”

Treating fat stem cells with low oxygen boosts hair growth cell growth through specific signaling pathways.

Hair Regenerative Effect of Silk Fibroin Hydrogel with Incorporation of FGF-2-Liposome and Its Potential Mechanism in Mice with Testosterone-Induced Alopecia Areata

research Hair regenerative effect of silk fibroin hydrogel with incorporation of FGF-2-liposome and its potential mechanism in mice with testosterone-induced alopecia areata

12 citations , September 2018 in “Journal of Drug Delivery Science and Technology”

The silk fibroin hydrogel with FGF-2-liposome can potentially treat hair loss in mice.

research Chemically induced transformation of human dermal fibroblasts to hair‐inducing dermal papilla‐like cells

8 citations , July 2019 in “Cell Proliferation”

Researchers found a way to turn skin cells into cells that can grow new hair.

research miR-129-5p Participates in Hair Follicle Growth by Targeting HOXC13 in Rabbit

5 citations , April 2022 in “Genes”

miR-129-5p affects hair growth by targeting the HOXC13 gene.

research Modulation of AR-FGF-2-TGF beta Axis by Cosmos caudatus Suppresses Prostatic Epithelial Proliferation in a BPH Rat Model: A Comparative Study with Finasteride

March 2026 in “Journal of Multidisciplinary Applied Natural Science”

Cosmos caudatus extract is as effective as finasteride for treating benign prostatic hyperplasia without its side effects.

The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β-Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells

research The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β- Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells

November 2024 in “Research Square (Research Square)”

Moracin M boosts hair growth by activating key pathways and promoting cell growth.