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GlossaryFibronectin

protein aiding cell adhesion and tissue repair

Fibronectin is a protein found in the extracellular matrix and blood plasma that plays a crucial role in cell adhesion, growth, migration, and wound healing. It helps cells stick to each other and to the surrounding environment, which is essential for tissue repair and maintaining the structural integrity of tissues.

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research Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle.

45 citations , August 1992 in “PubMed”

The rat vibrissa follicle can quickly remodel its basement membrane during hair growth, affecting cell signaling and activity.

research Expression of laminin, type IV collagen and fibronectin molecules is related to embryonal skin and epidermal appendage morphogenesis.

10 citations , January 2001 in “PubMed”

Laminin, type IV collagen, and fibronectin help develop skin and hair structures in embryos.

research Acoustic Fabrication of Collagen–Fibronectin Composite Gels Accelerates Microtissue Formation

7 citations , April 2020 in “Applied Sciences”

Ultrasound helps create gels that speed up tissue formation.

research An injectable fibronectin3-alginate hydrogel driven by dynamic dissolving equilibrium for irregular wound repair

2 citations , July 2024 in “Materials Today Communications”

The FN3-Alg hydrogel effectively heals irregular wounds and promotes hair growth.

research Fibronectin Connecting Cell Sheet Based on Click Chemistry for Wound Repair

1 citations , January 2024 in “Advanced science”

Fibronectin-attached cell sheets improve wound healing and are safe and effective.

research Strength and Tenderness: Fibronectin Joins Hair Follicle Stem Cell Niche

August 2025 in “Journal of Investigative Dermatology”

Fibronectin is essential for hair follicle regeneration and may help rejuvenate aged skin.

research Epithelial Fibronectin meshwork controls skin regeneration

April 2025 in “Journal of Investigative Dermatology”

Fibronectin is essential for hair follicle regeneration by supporting stem cells.

research Responses of type II spiral ganglion neurites to stripes of laminin and fibronectin

January 2011

Type II spiral ganglion neurites avoid high concentrations of laminin and fibronectin.

research Inhibitory effect of angiogenin on the expression of type I collagen and fibronectin in dermal papilla cells from androgenetic alopecia areas

September 2018 in “Chinese Journal of Dermatology”

Angiogenin may help treat hair loss by reducing certain proteins in hair cells.

research EDA Fibronectin Microarchitecture and YAP Translocation During Wound Closure

September 2024

Correcting EDA fibronectin organization and YAP translocation can improve wound healing in fibrotic conditions.

research Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model

68 citations , March 2018 in “Biomaterials”

Large-scale fibronectin nanofibers help heal wounds and repair tissue in a skin model of a mouse.

Wnt7a Can Up-Regulate Cell Adhesion Related Protein Fibronectin Expression and Promote Cell Proliferation in Corneal Epithelial Cells

research Wnt7a can up-regulates cell adhesion related protein fibronectin expression and promotes cell proliferation in corneal epithelial cells

April 2023

Wnt7a helps corneal cells grow and stick together, aiding in repair.

research Immunofluorescent localization of collagen types I, III and IV, fibronectin, laminin, and basement membrane proteoglycan in developing mouse skin

20 citations , July 1987 in “Development Genes and Evolution”

research Intradermal adipocytes mediate fibroblast recruitment during skin wound healing

238 citations , March 2013 in “Development”

Fat cells help recruit healing cells and build skin structure during wound healing.

Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair

research Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair

204 citations , October 1999 in “EMBO journal”

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

research Human Wharton's Jelly Stem Cells and Its Conditioned Medium Enhance Healing of Excisional and Diabetic Wounds

84 citations , August 2013 in “Journal of Cellular Biochemistry”

Human Wharton's jelly stem cells improve wound healing.

research A current review of the cutaneous manifestations of renal disease

67 citations , September 2003 in “Journal of cutaneous pathology”

Skin problems are very common in people with end-stage kidney disease.

research Expression of basement membrane components through morphological changes in the hair growth cycle

53 citations , April 1985 in “Developmental Biology”

Fibronectin and other basement membrane components increase during hair growth and decrease during rest.

research Distribution of Extracellular Matrix Molecules in Human Hair Follicles

45 citations , December 1991 in “Annals of the New York Academy of Sciences”

ECM molecules are crucial for hair growth and development.

The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

research The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility

44 citations , June 2009 in “Biomaterials”

Skin cell clumping for hair growth is improved by a protein called fibronectin, which helps cells stick and move better.

research Nonviral in Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells

43 citations , September 2009 in “Stem Cells”

A nonviral method was developed to label and culture human hair follicle stem cells.

research Understanding the Nano‐topography Changes and Cellular Influences Resulting from the Surface Adsorption of Human Hair Keratins

41 citations , May 2012 in “Advanced Healthcare Materials”

Human hair keratins improve cell adhesion and growth on culture surfaces.

research The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites

28 citations , January 2015 in “Journal of Cell Science”

PINCH-1 is crucial for skin cell adhesion and movement, working with EPLIN and ILK.

Combination of Media, Biomaterials, and Extracellular Matrix Proteins to Enhance the Differentiation of Neural Stem/Precursor Cells into Neurons

research Combination of media, biomaterials and extracellular matrix proteins to enhance the differentiation of neural stem/precursor cells into neurons

25 citations , April 2012 in “Acta Biomaterialia”

Using certain small proteins with a growth factor and specific materials can increase the creation of neurons from stem cells.

research A woman with iatrogenic androgenetic alopecia responding to finasteride

13 citations , February 2007 in “British Journal of Dermatology”

EF and PXE not closely related.

research Isolation of Multipotent Nestin-Expressing Stem Cells Derived from the Epidermis of Elderly Humans and TAT-VHL Peptide-Mediated Neuronal Differentiation of These Cells

12 citations , May 2013 in “International Journal of Molecular Sciences”

Stem cells from elderly skin can become neurons, offering potential for brain therapy.

research The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes

11 citations , February 2022 in “Scientific Reports”

CD26+ fibroblasts improve skin healing and integration better than CD26− fibroblasts.

research Endothelin-1 combined with extracellular matrix proteins promotes the adhesion and chemotaxis of amelanotic melanocytes from human hair follicles in vitro

11 citations , August 2006 in “Cell Biology International”

Endothelin-1 helps amelanotic melanocytes stick and move better on certain proteins.

research Skin morphology of the mutant hairless USP mouse

11 citations , January 2005 in “Brazilian Journal of Medical and Biological Research”

Hairless USP mice have enlarged skin cysts as they age.

research Rice bran mineral extract increases the expression of anagen-related molecules in human dermal papilla through wnt/catenin pathway

9 citations , January 2017 in “Food & Nutrition Research”

Rice bran mineral extract may help promote hair growth and prevent hair loss.