119 citations
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November 2016 in “American journal of human genetics” Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
January 2025 in “SSRN Electronic Journal” 210 citations
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February 2008 in “Nature genetics” Mutations in the P2RY5 gene cause autosomal recessive woolly hair.
15 citations
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February 1999 in “The anatomical record” Some mutant mice have hair with abnormal cross-linking, mainly in the cuticle, not affecting other hair parts.
142 citations
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February 2016 in “Science” Foxc1 helps keep hair follicle stem cells inactive, preventing hair loss.
1 citations
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October 2008 in “Expert Review of Dermatology” Frontal Fibrosing Alopecia is a slowly progressing hair loss condition, likely underdiagnosed, with ineffective treatments, needing more research to understand it fully.
54 citations
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November 2007 in “Actas Dermo-Sifiliográficas” Early diagnosis of frontal fibrosing alopecia is crucial to prevent permanent hair loss.
January 2015 in “Hair transplant forum international” The document's conclusion cannot be provided because the content is not available.
78 citations
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May 2012 in “Journal of Investigative Dermatology” A specific gene mutation causes woolly hair and hair loss.
339 citations
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February 2014 in “Journal of The American Academy of Dermatology” Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.
21 citations
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October 2017 in “Journal of the European Academy of Dermatology and Venereology” Various potential triggers may be causing the rise in frontal fibrosing alopecia, and avoiding these could help stop the disease's increase.
1 citations
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June 2022 in “International Journal of Dermatology” FFA in men shows unique features and treatment results vary widely.
161 citations
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June 1993 in “Journal of Biological Chemistry” Trichohyalin helps in hair and skin cell structure and function by binding calcium and linking proteins.
September 2017 in “Journal of Investigative Dermatology” Thermal imaging is a useful non-invasive method to diagnose active inflammation in frontal fibrosing alopecia.
53 citations
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September 1999 in “Journal of Synchrotron Radiation” Keratinous tissues have multiple structural layers, including ordered keratin and lipid granules.
35 citations
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September 2003 in “Archives of dermatology” Tiger tail bands in hair are caused by wavy hair fibers with melanin, unlike straight fibers in normal hair.
8 citations
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June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” A boy's skin fragility and sparse hair were caused by a genetic mutation affecting skin cell adhesion.
4 citations
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January 2021 in “Acta Dermato Venereologica” Titanium nanoparticles may trigger frontal fibrosing alopecia, so avoid products with them.
45 citations
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April 2016 in “Journal of Dermatological Science” The Wnt/β-catenin pathway can activate melanocyte stem cells and may help regenerate hair follicles.
25 citations
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January 2014 in “Annals of Dermatology” Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.
19 citations
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August 2012 in “Cell death and differentiation” Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.
14 citations
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July 2021 in “Biomolecules” Centipeda minima extract helps hair grow by activating important growth signals and could be a promising hair loss treatment.
1 citations
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January 2011 in “International Journal of Trichology” Hair follicle stem cells have significant potential for treating various disorders.
March 2022 in “Indian Journal of Animal Research” Dog hair follicle stem cells can turn into fat cells.
April 2020 in “Journal of animal research” Canine hair follicles have stem cells in the bulge region.
June 2015 in “Vestnik dermatologii i venerologii” Growth factors influence hair growth and hair loss.
October 2024 in “Skin Research and Technology” Pili annulati causes zebra-striped hair but doesn't affect hair strength or quality of life.
1 citations
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June 2025 in “Journal of Clinical Medicine” Frontal fibrosing alopecia often occurs after menopause, with delayed diagnosis and possible links to certain medications and conditions.
2 citations
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January 2010 in “PubMed” Current treatments for postmenopausal frontal fibrosing alopecia stop hair loss but don't regrow hair.
2 citations
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August 2025 in “JAAD reviews.” Frontal fibrosing alopecia significantly affects men, often causing hair loss in eyebrows, beard, and sideburns.