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This study explored the efficacy and tolerance of a hair serum containing Silybum marianum extract, manganese PCA, and Lespedeza capitata extract in 30 men with androgenic alopecia following hair transplantation. Over 1 year, participants were divided into two groups: one using the serum with shampoo and the other using shampoo alone. Results indicated that the serum improved scalp tightness and discomfort shortly after use and enhanced hair condition and growth over time, with significant improvements noted from 1 to 12 months post-transplant. The serum was well-tolerated and accepted by patients, suggesting it as a beneficial dermocosmetic adjuvant for post-transplant hair care.

Cutaneous fibrosis is characterized by abnormal tissue remodeling due to chronic inflammation, tissue trauma, or autoimmune reactions, leading to decreased tissue function and reduced quality of life. The epithelial–mesenchymal transition (EMT) is identified as a critical factor in the development of fibrotic disorders, although its exact contribution compared to other cell sources is not fully understood. Recent findings highlight EMT's role in fibrogenesis and suggest new molecular targets for therapy. This review aims to enhance understanding of EMT's regulatory mechanisms in cutaneous fibrosis and explore potential treatment strategies.

This review discusses the advancement of hair follicle organoids towards immune-competent hair follicle microphysiological systems (HF-MPS), which aim to better replicate the immune, vascular, neural, and dynamic regulatory features of native hair follicles. These systems are particularly important for studying immune-mediated hair disorders like alopecia areata, where immune privilege collapse and inflammatory infiltration are key issues. The review outlines the structural basis of HF engineering and defines immune competence as maintaining immune privilege, regulating hair follicle cycling and regeneration, and managing inflammatory injury. It also explores engineering strategies such as local immune microenvironment control and dynamic perfusion. The applications of HF-MPS in disease modeling, drug evaluation, and regenerative medicine are discussed, emphasizing that these systems are evolving platforms rather than complete replacements for existing models.

The article introduces Homeodynamic Rejuvenation as a framework for addressing skin aging by restoring the skin's ability to manage stress and recover efficiently, rather than merely reversing visible signs of aging. This approach emphasizes homeodynamic plasticity, which is the skin's capacity to maintain function under stress. It integrates homeodynamics with exposome biology to reactivate cellular systems responsible for stress sensing, repair, and recovery. Five core processes—intracellular quality control, regenerative competence, metabolic resilience, cellular integrity, and structural integrity—are crucial for maintaining skin function. Disruption of these processes leads to skin aging, with dermatoporosis as a severe outcome. Homeodynamic Rejuvenation is evaluated through dynamic perturbation–recovery kinetics, linking biological processes to functional and clinical outcomes, thus providing a framework for enhancing skin resilience.

This study used single-cell RNA sequencing on skin tissues from six fine-wool sheep to explore the molecular mechanisms regulating hair follicle development and fiber diameter. A transcriptional atlas of the hair follicle microenvironment was constructed, identifying 14 distinct cell types and revealing that the ultra-fine wool group had a higher proportion of dermal papilla cells (DPCs), hair follicle stem cells, and outer root sheath cells. The study highlighted the role of DPCs in hair follicle growth, identifying three distinct states of DPCs and analyzing differentially expressed genes, such as CRABP1, which influences DPC proliferation. These findings provide insights into hair follicle biology and potential molecular targets for breeding ultra-fine wool sheep.

This paper challenges the traditional "stem cell–centric" view of hair follicle miniaturization in alopecia, suggesting instead a "niche-centered" perspective that emphasizes the role of collagen networks. While hair follicle stem cells (HFSCs) may remain present, their conversion into progenitor cells is impaired, contributing to miniaturization. The authors propose "niche identity," focusing on structural and mechanical constraints within the follicular niche, defined by five state variables: basement membrane integrity, adhesion apparatuses, fibrillar organization, mechanical set-points, and dynamic remodeling windows. These elements may be affected by androgen-biased remodeling, inflammation, and aging, leading to a low-output state. The paper also introduces the concept of "signal–structure mismatch" as a reason for unstable therapeutic outcomes and suggests a niche identity–oriented framework for future research.

Hair follicle organoids (HFOs) are emerging as valuable in vitro models that mimic the structure and function of native hair follicles, offering new insights into hair biology and disorders. This review discusses the construction of HFOs, emphasizing the importance of epithelial–mesenchymal interactions and comparing various generation strategies, such as primary cell-based co-culture systems and iPSC-derived methods. HFOs have applications in disease modeling, drug screening, and regenerative medicine, but face challenges like large-scale cultivation and standardization. Future advancements in biomaterials and bioengineering are anticipated to improve their physiological relevance and clinical translation potential.

This study investigated the impact of long-term 5α-reductase inhibitor (5-ARI) use on survival in men with renal cell carcinoma (RCC) using data from 31,927 men in Korea. The study found that long-term use of 5-ARIs, such as finasteride or dutasteride, was associated with significantly lower all-cause mortality, particularly in patients who did not undergo surgery or systemic therapy and had low comorbidity. The results suggest that androgen modulation through 5-ARIs may positively influence RCC progression, indicating potential for these inhibitors as adjunctive treatments in specific clinical scenarios.

The study investigates the effects of Dendrobium officinale polysaccharide (DOP) on hair regrowth in androgenetic alopecia (AGA) mice. Results indicate that DOP improves hair regrowth in a dose-dependent manner, with the high-dose group showing significant improvements in hair coverage, follicle density, dermal thickness, hair bulb diameter, and anagen phase proportion. The treatment was linked to decreased SRD5A1 expression, increased CYP19A1 expression, reduced local dihydrotestosterone and testosterone levels, and elevated p-ESR1 and KRT28/KRT71 expression. These changes suggest that DOP influences local steroid metabolism, ESR1 activation, and keratin-related follicular responses, enhancing follicular morphology and cycling. The findings propose a framework for further exploration of DOP in treating AGA.