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GlossaryGene Editing

technique to precisely alter an organism's DNA sequence

Gene editing, also known as genome editing, is a technique that allows scientists to alter an organism's DNA with high precision. This process involves adding, removing, or modifying specific genetic material at particular locations in the genome, often using tools like CRISPR-Cas9. It holds potential for treating genetic disorders, improving crop resilience, and even addressing hair loss conditions like alopecia by targeting and correcting the underlying genetic causes.

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research 312 CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells

1 citations , September 2019 in “Journal of Investigative Dermatology”

The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.

research Effect of gamma-ray exposure on the genome-editing efficiency of improved genome-editing via oviductal nucleic acids delivery (i-GONAD)

January 2025 in “EXPERIMENTAL ANIMALS”

Gamma-ray exposure improves genome editing efficiency in mice using the i-GONAD method.

research 476 Development of an intrinsic skin sensor for blood glucose level with CRISPR-mediated genome editing in epidermal stem cells

April 2017 in “Journal of Investigative Dermatology”

Researchers created a skin graft that senses blood glucose and could treat diabetes using CRISPR-edited stem cells.

research Genome-wide detection of RNA editing events during the hair follicles cycle of Tianzhu white yak

October 2022 in “BMC genomics”

RNA editing significantly affects hair growth and follicle cycling in the Tianzhu white yak.

Recent Advances in Genome-Editing Technology with CRISPR/Cas9 Variants and Stimuli-Responsive Targeting Approaches within Tumor Cells: A Future Perspective of Cancer Management

research Recent Advances in Genome-Editing Technology with CRISPR/Cas9 Variants and Stimuli-Responsive Targeting Approaches within Tumor Cells: A Future Perspective of Cancer Management

1 citations , April 2023 in “International Journal of Molecular Sciences”

New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa

research 924 Efficient genome editing using CRISPR/Cas9 ribonucleoprotein approach in iPS cells for recessive dystrophic epidermolysis bullosa

April 2019 in “Journal of Investigative Dermatology”

Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.

research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

60 citations , July 2020 in “ACS Nano”

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

research Generation of Cashmere Goats Carrying an EDAR Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing

33 citations , January 2018 in “International Journal of Biological Sciences”

CRISPR-Cas9 can successfully edit genes in large mammals like Cashmere goats.

research In vivo delivery of CRISPR-Cas9 genome editing components for therapeutic applications

46 citations , October 2022 in “Biomaterials”

research Emerging lipid–polymer hybrid nanoparticles for genome editing

10 citations , January 2024 in “Polymer Chemistry”

Lipid–polymer hybrid nanoparticles can improve genome editing delivery and outcomes.

research Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing

7 citations , August 2022 in “Journal of Nanobiotechnology”

Advancements in nanoformulations for CRISPR-Cas9 genome editing can respond to specific triggers for controlled gene editing, showing promise in treating incurable diseases, but challenges like precision and system design complexity still need to be addressed.

Recent Updates of the CRISPR/Cas9 Genome Editing System: Novel Approaches to Regulate Its Spatiotemporal Control by Genetic and Physicochemical Strategies

research Recent Updates of the CRISPR/Cas9 Genome Editing System: Novel Approaches to Regulate Its Spatiotemporal Control by Genetic and Physicochemical Strategies

June 2024 in “International Journal of Nanomedicine”

CRISPR/Cas9 has improved precision and control but still faces clinical challenges.

research Liposome-Based Carriers for CRISPR Genome Editing

August 2023 in “International Journal of Molecular Sciences”

Liposomes show promise for delivering CRISPR for gene editing but face challenges like delivery efficiency and safety concerns.

research CRISPR–Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing

149 citations , August 2022 in “Biochemistry (Moscow)”

CRISPR-Cas9 allows precise DNA editing but raises ethical concerns about modifying human embryos.

research A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing

9 citations , October 2022 in “Nature Communications”

The DiLiCre mouse model is an effective tool for precise genome editing using light.

research Generation of Genetically Modified Rats Using CRISPR/Cas9 Genome-Editing System to Reveal Novel Vitamin D Actions

January 2021 in “Medical Research Archives”

Genetically modified rats help reveal how vitamin D affects bone and skin health.

research Progress in Research and Prospects for Application of Precision Gene-Editing Technology Based on CRISPR–Cas9 in the Genetic Improvement of Sheep and Goats

March 2024 in “Agriculture”

CRISPR/Cas9 gene-editing shows promise for improving sheep and goat breeding but faces challenges with efficiency and accuracy.

The Prospect and Application Research Progress of Precision Gene Editing Technology Based on CRISPR/Cas9 in Livestock Genetics and Breeding

research The Prospect and Application Research Progress of Precision Gene Editing Technology Based on CRISPR/Cas9 in Livestock Genetics and Breeding

December 2023

CRISPR/Cas9 gene-editing shows promise for livestock breeding but faces challenges like low efficiency and off-target effects.

research Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia

119 citations , March 2020 in “Frontiers in Bioengineering and Biotechnology”

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

research An induced pluripotent stem cell-based approach for hair follicle development and regeneration

June 2024 in “Regenerative Therapy”

iPSCs show promise for hair regeneration but need more research to improve reliability and effectiveness.

research Structural Elements of DNA and RNA Eukaryotic Expression Vectors for In Vitro and In Vivo Genome Editor Delivery

5 citations , December 2022 in “Molecular Biology”

Effective delivery of gene editors is crucial for safe and successful gene editing in healthcare and agriculture.

research Efficient Editing of CSLD2 Orthologue by CRISPR/Cas9 Affects Cell Morphogenesis of Root Hair in Spinach

1 citations , January 2022 in “Research Square (Research Square)”

CRISPR/Cas9 editing in spinach affects root hair growth by altering specific genes.

research 688 Precise and efficient editing of the COL7A1 gene in RDEB derived iPSCs with CRISPR/Cas9 and prime editing

July 2024 in “Journal of Investigative Dermatology”

CRISPR/Cas9 and prime editing can potentially fix skin disorder genes safely and effectively.

research Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations

6 citations , October 2022 in “International Journal of Molecular Sciences”

Male mice with FGF5 mutations grow longer hair than females.

research Editorial overview: Embroidering the canvas of life

October 2018 in “Current Opinion in Genetics & Development”

The document emphasizes the importance of ongoing research and ethical considerations in genome editing and cellular reprogramming.

research Abstracts

2 citations , January 2019 in “Medizinische Genetik”

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

Developmental Mechanisms Controlling Cell Fate Evolution

research Current and prospective strategies for advancing the targeted delivery of CRISPR/Cas system via extracellular vesicles

21 citations , June 2023 in “Journal of Nanobiotechnology”

Engineered extracellular vesicles could improve CRISPR/Cas delivery, making gene editing safer and more effective.