Intelligent Nanotherapeutic Strategies for the Delivery of CRISPR System

December 2022 in “ Acta Pharmaceutica Sinica B ”

Chao Chen, Wu Zhong, Shiyu Du, Yayao Li, Yunfei Zeng, Kunguo Liu, Jingjing Yang, Xiaoxiang Guan, Xin Han

TLDR Smart delivery methods for CRISPR gene editing are crucial for clinical success.

This review discussed the therapeutic application and translational potential of CRISPR gene editing, highlighting the importance of developing intelligent and precise delivery strategies for clinical use. It analyzed the challenges of delivering the CRISPR system in vivo and its inherent limitations. The focus was on stimuli-responsive nanocarriers, which showed promise in delivering the CRISPR-Cas9 system by responding to various endogenous and exogenous signals. Additionally, the review covered new genome editors mediated by nanotherapeutic vectors and explored future prospects for genome editing using existing nanocarriers in clinical settings.

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