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Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells

research Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome K_ATPChannel Mutations in Intact Cells

1 citations , August 2023 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

research Canadian Expert Recommendations on Safety Overview and Toxicity Management Strategies for Sacituzumab Govitecan Based on Use in Metastatic Triple-Negative Breast Cancer

6 citations , September 2024 in “Current Oncology”

Sacituzumab Govitecan is effective for certain breast cancers but requires careful management of side effects.

research Scraggly, a new hair loss mutation on mouse Chromosome 19

14 citations , September 1999 in “Mammalian genome”

The scraggly mutation causes hair loss and skin defects in mice.

research HOTTIP Mediated Therapy Resistance in Glioma Cells Involves Regulation of EMT-Related miR-10b

10 citations , March 2022 in “Frontiers in Oncology”

HOTTIP and miR-10b contribute to glioma therapy resistance by affecting cell behavior, suggesting they could be targets for treatment.

research Induction of Vascular Endothelial Growth Factor Messenger Ribonucleic Acid Expression in Stored Micrografts by Aminoguanidine

3 citations , November 2005 in “Dermatologic Surgery”

Aminoguanidine increases a specific growth signal in stored hair grafts, which may help them survive better after being transplanted.

research Decision letter: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma

August 2021

The microenvironment affects the behavior and survival of melanocytes with the GNAQ oncogene in melanoma.

research EGFR: stopping stathmin to start the cycle

March 2016 in “Experimental Dermatology”

EGFR helps hair follicles transition properly by controlling Stathmin levels.

research Mice Expressing a Mutant Krt75 (K6hf) Allele Develop Hair and Nail Defects Resembling Pachyonychia Congenita

46 citations , September 2007 in “Journal of Investigative Dermatology”

research Insertional mutation of the hairless locus on mouse Chromosome 14

19 citations , November 1993 in “Mammalian Genome”

A gene mutation in mice causes permanent hair loss and skin issues.

research Pitfalls of PCR-Based Strategy for Genotyping Cre-Loxpi> Mice

6 citations , March 2007 in “BioTechniques”

PCR genotyping in cre-loxP mice can be inaccurate due to unintended gene deletions in non-target tissues.

research Gfp-Expressing Vascularization of Gelfoam® as a Rapid in Vivo Assay of Angiogenesis Stimulators and Inhibitors
15 citations , March 2007 in “BioTechniques”

The assay quickly identifies substances that increase or decrease blood vessel growth.

research 420 Severe thiopurine-induced myelotoxicity and hair loss in Japanese patients with NUDT15 gene variant: A retrospective case-control study
April 2018 in “Journal of Investigative Dermatology”

Screening for the NUDT15 gene variant can prevent severe side effects from thiopurine drugs in East-Asian people.

research Molecular modeling and structural characterization of a high glycine–tyrosine hair keratin associated protein
16 citations , January 2017 in “Physical chemistry chemical physics/PCCP. Physical chemistry chemical physics”

The 3D structure of a key hair protein was modeled, revealing specific helical structures and stabilization features.

research Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
65 citations , February 2011 in “Molecular cancer therapeutics”

CCT128930 is a promising new drug that effectively targets and inhibits a cancer-related protein, showing potential for cancer treatment.

research One Transgene: Two Outcomes
July 2002 in “Science s STKE”

Modified β-catenin causes different effects in hair and skin cells, leading to cysts or tumors.

research Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway
137 citations , October 2009 in “The American journal of pathology”

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

research Hague (Hagi>): A New Mouse Hair Mutation With an Unstable Semidominant Allele
11 citations , October 2002 in “Genetics”

A new mouse hair mutation, called hague, is semidominant and unstable, but the exact cause is unknown.

research Type A insulin resistance syndrome due to a novel heterozygous c.3486_3503del (p. Arg1163_Ala1168del) INSR gene mutation in an adolescent girl and her mother
January 2024 in “Archives of Endocrinology and Metabolism”

A new gene mutation causes insulin resistance in a girl and her mother.

research Virtual Screening for the Discovery of Microbiome β-Glucuronidase Inhibitors to Alleviate Cancer Drug Toxicity
9 citations , March 2022 in “Journal of Chemical Information and Modeling”

New inhibitors may reduce gut toxicity from cancer drugs.

research The Relationship Between Glycine and Gephyrin in Synapses of the Rat Spinal Cord
110 citations , January 1995 in “European Journal of Neuroscience”

Glycine is a key transmitter in rat spinal cord synapses, often alongside GABA.

research 199 Impairment of notch 1 signaling is a common defect in lesions from patients with hidradenitis suppurativa
2 citations , September 2017 in “Journal of Investigative Dermatology”

Notch1 signaling is impaired in hidradenitis suppurativa, affecting skin and hair cells.

research Pathological findings in a case of stiff person syndrome with anti‐GAD antibodies
17 citations , May 2011 in “Movement Disorders”

Finasteride significantly reduced tics and obsessive-compulsive symptoms in patients with Tourette syndrome.

research Abstracts
7 citations , March 2023 in “Lasers in Surgery and Medicine”

Ablative fractional laser treatment nearly matches the gene reduction effects of topical vismodegib in skin cancer.

research SF-066-4 線維芽細胞+血管内皮前駆細胞共培養シートを用いた新たな膵断端処理法の開発(膵-2,サージカルフォーラム,第110回日本外科学会定期学術集会)
March 2010 in “日本外科学会雑誌”

Metabolic processes and key genes like FGF5, FGFR1, and RRAS significantly affect hair follicle growth in Inner Mongolian Cashmere goats.

research More about X‐linked testicular feminization of the mouse as a noninducible (i^s) mutation of a regulatory locus: 5α‐androstan‐3α‐17ß‐diol as the true inducer of kidney alcohol dehydrogenase and ß‐glucuronidase
38 citations , May 1971 in “Clinical genetics”

A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.

research Maximizing surgical outcomes with gender affirming hormone therapy in gender affirmation surgery
9 citations , May 2024 in “Journal of Clinical & Translational Endocrinology”

Gender affirming hormone therapy improves outcomes in gender affirmation surgery.

research CD8-positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice
7 citations , February 2015 in “Journal of comparative pathology”

CD8+ T cells play a key role in graft-versus-host disease in certain mice models.

research Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells
35 citations , April 2009 in “Journal of Neuroscience Research”

HDAC inhibitors help brain cells grow and improve brain function.

research New intranasal and injectable gene therapy for healthy life extension
June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Gene therapy in mice increased lifespan and improved health without causing cancer.

research Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation
2 citations , January 2014 in “Photochemical & photobiological sciences”

Grasp protein helps maintain skin health after UVB exposure.

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