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Neurotoxins can affect neurotransmitter release and have potential in treating muscle, pain, and cancer conditions, but more research is needed on how they work.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Transglutaminases help form strong hair by linking proteins, and can potentially alter hair properties.

Transamidases are present in the epidermis but their exact role is unclear.

Sphingosine 1-phosphate helps control mechanical pain.

The availability of certain hormones and specific stimulation patterns affect long-term synaptic changes in the male rat brain.

TRPV3 channels are involved in skin processes and are affected by shear stress, influencing itch and mechanotransduction.

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

Acetylcholine receptors might be involved in the development of acne inversa and smoking could worsen the condition.

Mechanoreceptors convert physical touch into electrical signals through specialized nerve structures.

A new skin-whitening agent using a peptide from wheat is safe and effective at reducing skin pigmentation.

GLP-1 therapies, especially semaglutide and tirzepatide, may cause hair loss, particularly in women and with rapid weight loss.

GLABRA 2 controls ethylene production to help root hair growth during nutrient deficiency.

Transglutaminase activity is important for skin and is found in both mammals and birds.

MSG-based hair hardener improves hair thickness, strength, and wave retention after perms.

Sinapic acid and glabridin together help hair growth in androgenetic alopecia.

GLP1-RAs may have higher reports of suicide and hair loss, but no strong evidence links them to these issues.

Keloid fibroblasts cause itch and pain by releasing more histamine.

The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.

HSD11b1 affects skin nerves and increases non-histaminergic itch.

The VMH AMPK-SNS-BAT axis may help treat cachexia and obesity.

AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.

Benzothiazepines like diltiazem reduce anxiety in mice by making neurosteroids.

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

TRPV4 helps sense pressure in mouse skin.

Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.