research Dopamine is a novel, direct inducer of catagen in human scalp hair folliclesin vitro
Dopamine stops hair growth and pigment production in human scalp hair follicles.
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research The promise and challenges of cell therapy for psoriasis*
Cell therapy shows promise for treating severe psoriasis but needs more research to confirm safety and effectiveness.
research Utilizing the hair follicle to dissect the regulation and autocrine/paracrine activities of prolactin in humans
Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.
research Topical Treatments for Scalp Psoriasis
Some topical treatments like corticosteroids and vitamin D analogues are effective for scalp psoriasis, but more long-term data is needed.
research Epidermal growth factor receptor/mitogen-activated kinase inhibitor treatment induces a distinct inflammatory hair follicle response that includes collapse of immune privilege
EGFRi/MEKi treatments cause hair follicles to lose some immune protection, leading to inflammation.
research 1616 Cross-comparison of inflammatory skin disease transcriptomics identifies PTEN as a pathogenic disease classifier in cutaneous lupus erythematosus
PTEN was identified as a specific marker for the skin disease cutaneous lupus erythematosus, and it helps increase the expression of harmful type I interferons.
research 861 EGFR/MEK inhibitor therapy induces partial hair follicle immune privilege collapse in vivo and ex vivo
research Issue Information
research Issue Information
research 422 Human hair follicles express PD-L1, whose expression is down-regulated by EGFR and MEK inhibitors ex vivo. A potential mechanism for EGFR inhibitor induced sterile folliculitis
EGFR and MEK inhibitors reduce PD-L1 in hair follicles, possibly causing inflammation.
research LIGA R and D and prototyping[Lithography, Electroforming, and Assembly]
research Response
The authors agree they didn't follow the original criteria strictly but found the Ottawa rule effective in all tested patients and suggest it might have wider use.
research LGR5 is a Marker of Poor Prognosis in Glioblastoma and is Required for Survival of Brain Cancer Stem‐Like Cells
High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.
research Diagnostic and grading criteria for androgenetic alopecia using dermoscopy
New dermoscopic criteria accurately diagnose and grade the severity of hair loss in androgenetic alopecia.
research Prediction of gain-of-function and loss-of-function mutations using Combined Annotation Dependent Depletion (CADD)
C-scores can help predict gain-of-function and loss-of-function mutations.
research Characterization and isolation of stem cell–enriched human hair follicle bulge cells
Researchers successfully isolated and identified key stem cells in human hair follicles, which could help develop new skin and hair treatments.
research Prevention of doxorubicin-induced alopedia by scalp hypothermia: relation to degree of cooling.
Cooling the scalp below 22°C before and during chemotherapy can help prevent hair loss.
research Dermatological practice and psychiatry
Many skin patients have mental health issues, so dermatologists should consider psychological care.
research A new classification of early female pattern hair loss
The new system helps detect and track early female hair loss better.
research Characterization of a Test for Invasive Breast Cancer Using X-ray Diffraction of Hair—Results of a Clinical Trial
Combining hair x-ray diffraction with mammography improves breast cancer detection.
research Validation and clinical relevance of a novel scalp coverage scoring method
The new scalp coverage scoring method accurately measures hair loss and growth in men.
research Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell
Certain drugs change freshwater snail shells to a "banana" shape.
research Cross-species amplification of human microsatellite markers in pig-tailed and stump-tailed macaques
Some human genetic markers work for genetic studies in pig-tailed and stump-tailed macaques, which can help in their conservation.
research Literature Reviews
A new hair transplant method showed promising results and a study found how deep a CO₂ laser can penetrate skin.
research A Quantitative Measurement Method for Nuclear-Pleomorphism Scoring in Breast Cancer
A new method accurately measures cell changes in breast cancer.
research Neurosteroid Synthesis-Mediated Regulation of GABAAReceptors: Relevance to the Ovarian Cycle and Stress
Ovarian and stress hormones can change GABA A receptors through neurosteroids.
research British A ssociation of D ermatologists' guidelines for the management of tinea capitis 2014
Accurate diagnosis and effective oral treatment are key to managing tinea capitis and preventing its spread.
research Significance of the S100A4 Protein in Psoriasis
The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.
research Continued improvement in pressure-flow parameters in men receiving finasteride for 2 years
Finasteride improves urinary function in men for 2 years.
research Severe, Disfiguring, Pityriasis Rubra Pilaris in a Woman in the Dominican Republic
A woman with HIV had a severe skin condition that improved with antiretroviral therapy.