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Did you mean Growth Differentiation Factor 8?

GlossaryGrowth Differentiation Factor 8

inhibits muscle growth by signaling muscles to stop growing

Growth Differentiation Factor 8 (GDF-8), also known as Myostatin, is a protein that inhibits muscle growth. It plays a crucial role in regulating muscle mass by signaling muscles to stop growing, ensuring that muscle growth does not become excessive. This protein is of particular interest in medical research for its potential implications in treating muscle-wasting diseases and enhancing muscle growth in livestock.

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Growth Differentiation Factor 11 (GDF11)/Transforming Growth Factor-β (TGF-β)/Mesenchymal Stem Cells (MSCs) Balance: A Complex Partnership in Skin Rejuvenation

research Growth Differentiation Factor 11 (GDF11)/Transforming Growth Factor - β (TGF - β)/Mesenchymal Stem Cells (MSCs) Balance: A Complicated Partnership in Skin Rejuvenation

1 citations , January 2019 in “Journal of Embryology & Stem Cell Research”

MSCs help rejuvenate skin by promoting cell growth and reducing inflammation.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts

20 citations , January 2019 in “Journal of dermatological science”

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

Platelet-Derived Growth Factor Regulates the Proliferation and Differentiation of Human Melanocytes in a Differentiation-Stage-Specific Manner

research Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner

10 citations , May 2016 in “Journal of Dermatological Science”

PDGF-BB helps young melanocytes grow but stops mature ones from growing, and it makes melanocytes more specialized.

Astragalus Membranaceus and Cinnamomum Cassia Stimulate Hair Follicle Differentiation-Related Growth Factor via Wnt/Beta-Catenin Pathway

research Astragalus membranaceus and Cinnamomum cassia Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt/β-Catenin Signaling Pathway

October 2023 in “Current Issues in Molecular Biology”

The YH complex, made from Astragalus membranaceus and Cinnamomum cassia, may help treat hair loss by promoting hair growth and follicle development.

research Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin

90 citations , August 2004 in “Physiological Genomics”

Dermal papilla cells help skin stem cells grow into hair.

Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors to Improve Skin Regeneration

research Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors To Improve Skin Regeneration

5 citations , September 2019 in “ACS Applied Bio Materials”

The hydrogel with bioactive factors improves skin healing and regeneration.

HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

research HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells in vitro

7 citations , March 2021 in “Molecular Medicine Reports”

A mix of specific inhibitors and a growth factor helps keep hair growth cells from losing their properties in the lab.

research Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation

7 citations , October 2011 in “BMC Cancer”

Overexpression of HDGF in melanocytes does not cause cancer.

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

research Histochemical and Immunohistochemical Markers for Human Eccrine and Apocrine Sweat Glands: An Aid for Histopathologic Differentiation of Sweat Gland Tumors

73 citations , November 2001 in “Journal of Investigative Dermatology Symposium Proceedings”

Markers help differentiate between apocrine and eccrine sweat glands to identify sweat gland tumors.

research Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseases

17 citations , October 2021 in “Cellular & Molecular Biology Letters”

New biomarkers and potential treatments for skin diseases were identified.

research Dendritic Cell–Associated MARCKSL1 Regulates Fibroblast Differentiation During Wound Healing

March 2026 in “Wound Repair and Regeneration”

MARCKSL1 is important for wound healing and could be a target to reduce scarring.

research Regulation of adipocyte dedifferentiation at the skin wound edge

November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Adipocytes can change into fibroblast-like cells to help with wound healing.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

research DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

3 citations , January 2023 in “Science advances”

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

research TGFβ‐mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound‐induced skin fibrosis

3 citations , July 2024 in “Cell Proliferation”

Blocking TGFβ can help treat fibrotic skin conditions by promoting fat cell formation.

research Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

130 citations , March 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

127 citations , March 2016 in “PLoS ONE”

Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.

research Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization

169 citations , January 2020 in “Burns & Trauma”

Platelet-rich plasma speeds up skin wound healing.

research Impaired Keratinocyte Proliferative and Clonogenic Potential in Transgenic Mice Overexpressing 14-3-3σ in the Epidermis

15 citations , June 2011 in “Journal of Investigative Dermatology”

Overexpressing 14-3-3σ in mice skin reduces cell growth and hair density.

research AB0163 ANTI-KU ANTIBODIES: MUCH MORE THAN SCLEROMYOSITIS

June 2020 in “Annals of the Rheumatic Diseases”

Patients with Systemic Sclerosis have much higher levels of GDF-15, which could help predict organ involvement and guide treatment.

research MOF-mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions By Controlling Gene Promoters

November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

MOF controls skin development by regulating genes for mitochondria and cilia.

research An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys)

June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

A specific molecular switch, driven by MAPK/ERK signaling, helps spiny mice heal wounds by regenerating skin instead of forming scars.

research The hair cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research The hair cycle

103 citations , January 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Comprehensive transcriptome and methylome analysis delineates the biological basis of hair follicle development and wool-related traits in Merino sheep

112 citations , September 2021 in “BMC Biology”

Key genes and factors crucial for hair follicle development and wool traits in Merino sheep were identified.

research Platelet-Rich Plasma in Cosmetic Surgery

5 citations , January 2013 in “Otorhinolaryngology clinics : an international journal”

Platelet-rich plasma may improve healing and hair growth in cosmetic surgery but results vary.

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Related Terms

Research

research Growth Differentiation Factor 11 (GDF11)/Transforming Growth Factor - β (TGF - β)/Mesenchymal Stem Cells (MSCs) Balance: A Complicated Partnership in Skin Rejuvenation

research Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts

research Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner

research Astragalus membranaceus and Cinnamomum cassia Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt/β-Catenin Signaling Pathway

research Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin

research Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors To Improve Skin Regeneration

research HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells in vitro

research Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

research All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research Histochemical and Immunohistochemical Markers for Human Eccrine and Apocrine Sweat Glands: An Aid for Histopathologic Differentiation of Sweat Gland Tumors

research Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseases

research Dendritic Cell–Associated MARCKSL1 Regulates Fibroblast Differentiation During Wound Healing

research Regulation of adipocyte dedifferentiation at the skin wound edge

research DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

research TGFβ‐mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound‐induced skin fibrosis

research Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

research Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization

research Impaired Keratinocyte Proliferative and Clonogenic Potential in Transgenic Mice Overexpressing 14-3-3σ in the Epidermis

research AB0163 ANTI-KU ANTIBODIES: MUCH MORE THAN SCLEROMYOSITIS

research MOF-mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions By Controlling Gene Promoters

research An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys)

research The hair cycle

research The hair cycle

research Comprehensive transcriptome and methylome analysis delineates the biological basis of hair follicle development and wool-related traits in Merino sheep

research Platelet-Rich Plasma in Cosmetic Surgery

research Epidermal Renewal after Treatment of Primary Canine Hypothyroidism using Levothyroxine

research Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart

research The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair