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Disrupting a specific protein's function in hair follicle stem cells triggers their activation and a self-healing process.

A skin condition called pyodermatitis vegetans was found in a patient with multiple myeloma for the first time.

Sebaceous gland atrophy and abnormal function may contribute to hair loss in psoriasis.

RPGRIP1L helps skin cells stick together by blocking PKCβII, which can prevent skin blistering like in pemphigus.

Nirogacestat can cause severe skin issues like hidradenitis suppurativa.

A new compound slows cancer cell growth and causes cell death by blocking cell cycle progression and increasing cell-damaging molecules.

Mutations in the enzyme don't significantly change how it binds to its specific substances.

Keratinocytes can reverse the effects of the GNAQ oncogene, inhibiting melanoma cell growth.

EGFR hyperactivation increases sebaceous gland size and sebum production in mice.

Applying certain vesicles from umbilical cord stem cells helps heal skin wounds in diabetic mice by reducing cell death and inflammation.

mrp/plf-mRNA can indicate tumor-promoting effects in skin.

A gene deletion in DSG4 causes sparse hair in some Pakistani families.

Deleting TNFα gene reduces skin cancer risk in certain mice.

Lack of TG2 increases fat storage and lowers cell cleanup in skin oil cells.

A patient with a PLEC mutation has epidermolysis bullosa, muscular dystrophy, and myasthenia gravis, which improved with steroid treatment.

Normal human melanocytes can avoid cell death through multiple pathways.

Plakophilin 1 helps control skin cell immune responses to prevent excessive inflammation.

Removing certain hair follicle stem cells worsens skin reactions to allergens.

Blocking Prostaglandin D₂ (PGD₂) could help treat hair loss.

Mutations in the DSG4 gene cause specific hair and scalp issues.

Newly designed proteins can effectively degrade specific proteins in cells, offering a promising alternative for targeted protein degradation.

PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.

Mice with extra PKCδ resist chemical-induced skin cancer but not UV-induced.

An infant with Hutchinson-Gilford Progeria Syndrome had successful surgery to fix breathing issues caused by a new genetic mutation.

Keratinocytes can reduce the survival of certain melanoma cells, suggesting new therapy paths.

Melanocyte pathology requires keratinocyte hyperplasia and regulation dysfunction.

Targeted siRNA therapy may be a promising treatment for KID syndrome by reducing mutant gene expression and improving cell communication.

New mouse models of Pemphigus show severe symptoms and need better treatments.

Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.