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GlossaryHair Bulb

rounded base of the hair follicle where growth starts

The hair bulb is the rounded, bulbous structure at the base of the hair follicle, located in the dermis layer of the skin. It is the site where hair growth begins, containing actively dividing cells that produce the hair shaft and the inner root sheath. The hair bulb also houses the dermal papilla, which supplies nutrients and signals necessary for hair growth.

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Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro

58 citations , June 1987 in “Archives of Dermatological Research”

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

research Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors

46 citations , April 2014 in “PLOS ONE”

Gray hair may be caused by lower antioxidant activity in hair cells.

research Cellular Activity in the Dermis Surrounding the Hair Bulb in Alopecia Areata

25 citations , October 1975 in “Journal of Cutaneous Pathology”

Hair growth in alopecia areata is hindered due to impaired cell activity in the surrounding tissue.

Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles for Effective Preservation and Delivery of Fermented Herbal Extract for Enlarging Hair Bulb and Enhancing Hair Growth

research <p>Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles For Effective Preservation And Delivery Of Fermented Herbal Extract For Enlarging Hair Bulb And Enhancing Hair Growth</p>

22 citations , October 2019 in “International Journal of Nanomedicine”

The nanoparticles improved hair growth and enlarged hair bulbs.

research In vitro effects of testosterone, dihydrotestosterone and estradiol on cell growth of human hair bulb papilla cells and hair root sheath fibroblasts.

22 citations , July 1990 in “Acta Dermato Venereologica”

High levels of testosterone and dihydrotestosterone inhibit hair cell growth, while high levels of estradiol promote it.

Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and Pilomatricoma

research Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma

20 citations , February 2016 in “American Journal of Pathology”

The genes OVOL1 and OVOL2 are important for hair growth and may be involved in a type of skin tumor.

The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients

18 citations , January 2017 in “Annals of dermatology/Annals of Dermatology”

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

research Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro

9 citations , March 1987 in “British Journal of Dermatology”

EGF and FGF can boost hair growth by speeding up cell growth.

research Effects of testosterone, dihydrotestosterone and estradiol on the growth behavior of cultured hair bulb papilla cells and root sheath fibroblasts

5 citations , January 1989

Testosterone and dihydrotestosterone slow hair cell growth, while estradiol has no effect.

research “Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women”

3 citations , May 2019 in “Journal of Cosmetic Dermatology”

Miliacin with polar lipids helps hair growth and improves hair loss in women.

Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation

research Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation

3 citations , July 2011 in “Folia Histochemica et Cytobiologica”

Calcium reduces involucrin in rat hair bulbs but doesn't affect filaggrin and Kdap.

research A Short Peptide GPIGS Promotes Proliferation of Hair Bulb Keratinocytes and Accelerates Hair Regrowth in Mice

3 citations , January 2005 in “Biological & Pharmaceutical Bulletin”

The peptide GPIGS helps hair cells grow and speeds up hair regrowth in mice.

Comparing the Delivery to the Hair Bulb of Two Fluorescent Molecules of Distinct Hydrophilicities by Different Nanoparticles and a Serum Formulation

research Comparing the delivery to the hair bulb of two fluorescent molecules of distinct hydrophilicities by different nanoparticles and a serum formulation

2 citations , April 2021 in “International Journal of Pharmaceutics”

Serum formulations were better at delivering molecules to the hair bulb than nanoparticles.

research Can a topical scalp treatment reduce hair bulb extraction?

2 citations , October 2007 in “PubMed”

Topical scalp treatments could potentially reduce hair extraction.

research DNA determination of human hair bulbs in normal and androgenetic alopecia

1 citations , August 1994 in “Journal of Cutaneous Pathology”

Hair loss happens due to faster cell growth and fewer cells in affected follicles.

research Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles For Effective Preservation And Delivery Of Fermented Herbal Extract For Enlarging Hair Bulb And Enhancing Hair Growth

October 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)”

The nanoparticles effectively deliver herbal extract to enhance hair growth.

research 083 More Expression of IL-17 than IFN-γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion

September 2019 in “Journal of Investigative Dermatology”

IL-17 and certain immune cells are linked to more severe alopecia areata.

research [Skin-like structure generated from implantation of hair follicle bulb cells into collagen/chitosan porous scaffolds in vitro].

July 2004 in “PubMed”

Hair bulb cells can create skin-like tissues for potential skin repair.

research Quantification of Squalene and Lactic Acid in Hair Bulbs with Damaged Sheaths: Are They Metabolic Wastes in Alopecia?

September 2023 in “Biomedicines”

Squalene may be a marker for certain types of alopecia.

research Do Hair Bulb Melanocytes Undergo Apotosis During Hair Follicle Regression (Catagen)?

130 citations , December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle melanocytes die during hair regression.

research Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation

19 citations , November 2001 in “Journal of Investigative Dermatology Symposium Proceedings”

Human hair follicles can regenerate and recover after severe injury by going through a brief abnormal resting phase before growing again.

research [Proliferation behavior of the anagen hair bulb in androgenetic alopecia before and after local administration of 17 alpha- propylmesterolone–DNA flow cytophotometry studies].

December 1990 in “PubMed”

Topical 17 alpha-propylmesterolone increases hair cell growth in androgenetic alopecia.

research Eosinophils in fibrous tracts and near hair bulbs: A helpful diagnostic feature of alopecia areata

64 citations , July 1997 in “Journal of The American Academy of Dermatology”

Finding eosinophils near hair bulbs helps diagnose alopecia areata.

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

August 2023 in “International Journal of Molecular Sciences”

The human scalp hair bulb contains different types of melanocytes with varying abilities to produce melanin.

research 883 Hair follicle bulb developed as 3D scaffold free microtissue

April 2017 in “Journal of Investigative Dermatology”

Scientists created a tiny, 3D model of a hair follicle that grows and acts like a real one.

research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

July 2023

The human scalp has different types of pigment cells in hair follicles with varying abilities to produce pigment.

research Activation of the OVOL1-OVOL2 axis in the hair bulb and in pilomatricoma and pilomatrix carcinoma

September 2016 in “Journal of dermatological science”

The OVOL1-OVOL2 axis is important for hair follicle differentiation and can help diagnose certain hair-related tumors.

research Pro-inflammatory Vδ1+T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles

23 citations , September 2020 in “Journal of Dermatological Science”

Targeting Vδ1+T-cells may help treat alopecia areata.

Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

research Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp

14 citations , October 2020 in “Scientific reports”

Hair greying is linked to reduced ATM protein in hair cells, which protects against stress and damage.

research NEW NON SYNTHETIC MOLECULES ARE ABLE TO INHIBIT APOPTOSIS IN DERMAL PAPILLAR CELLS OF HAIR BULB

January 2011 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)”

New molecules can prevent cell death in hair follicles.