1308 citations
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March 1998 in “Journal of bone and mineral research” The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
508 citations
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February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
408 citations
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January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
343 citations
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December 2008 in “Endocrine Reviews” Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.
326 citations
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February 2009 in “The American journal of pathology” Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.
277 citations
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July 2002 in “Molecular Endocrinology” Removing part of the vitamin D receptor stops vitamin D from working properly.
237 citations
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February 2016 in “Science Translational Medicine” The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.
222 citations
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January 2005 in “Endocrine journal” Melatonin is important for skin health and protection, and can be made by the skin or applied to it.
156 citations
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October 2012 in “Seminars in Cell & Developmental Biology” Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.
135 citations
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December 2015 in “Expert Opinion on Biological Therapy” Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.
127 citations
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January 2008 in “PloS one” Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.
125 citations
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September 2019 in “Journal of Clinical Immunology” Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.
124 citations
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July 2012 in “Archives of Dermatological Research” Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
121 citations
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March 1989 in “Journal of Investigative Dermatology” Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.
120 citations
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February 2009 in “Apoptosis” Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.
116 citations
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August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
111 citations
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June 2002 in “The EMBO Journal” Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.
106 citations
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April 2013 in “Dermatologic Surgery” Low-level light therapy safely improves hair growth and thickness for androgenetic alopecia.
100 citations
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July 2004 in “The Journal of Sexual Medicine” Hormones like estrogen, testosterone, progesterone, and prolactin play complex roles in female sexual function, with testosterone potentially improving sexual desire, arousal, and satisfaction. However, more research is needed to establish safe and effective hormone treatments for female sexual dysfunction.
98 citations
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April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively blocks rat enzymes, but with varying methods and strength.
90 citations
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October 1983 in “British Journal of Dermatology” The unit area trichogram is a reliable method to assess hair loss and treatment response in people with androgenic alopecia by measuring hair density and thickness.
77 citations
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March 2001 in “Clinics in Dermatology” Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.
76 citations
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June 2015 in “Journal of biomedical science” Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.
72 citations
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January 2001 in “Drugs” Minoxidil and finasteride treat hair loss; more research needed for other options.
71 citations
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February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
69 citations
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April 2017 in “BMJ open” Many people with alopecia experience high levels of social anxiety, anxiety, and depression, and while wigs can boost confidence, they may also cause anxiety.
67 citations
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August 2007 in “American Journal of Pathology” Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.
64 citations
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March 2017 in “Journal of Cosmetic Dermatology” PRP treatment may increase hair density and reduce hair loss, but more research is needed.
62 citations
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April 2008 in “Neurobiology of aging” Scientists found a gene in mice that causes early hearing loss.
57 citations
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July 2005 in “Genetics” Key genes are crucial for Drosophila wing development and could be insecticide targets.