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GlossaryHair Cycle Arrest

normal hair growth phases are disrupted, halting new hair production

Hair Cycle Arrest refers to a condition where the normal cycle of hair growth is disrupted, causing hair follicles to stop progressing through their usual phases of growth, rest, and shedding. This can lead to thinning hair or hair loss, as the follicles remain in a dormant state and fail to produce new hair. It can be caused by various factors, including hormonal imbalances, stress, or underlying medical conditions.

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Adrenal Steroid Hormone Concentrations in Dogs with Hair Cycle Arrest (Alopecia X) Before and During Treatment with Melatonin and Mitotane

research Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane

52 citations , October 2004 in “Veterinary dermatology”

Melatonin and mitotane treatment led to hair re-growth in 62% of dogs with Alopecia X, but this was not always linked to normal hormone levels.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research Oestrogen receptor evaluation in Pomeranian dogs with hair cycle arrest (alopecia X) on melatonin supplementation

20 citations , July 2006 in “Veterinary dermatology”

Melatonin helped some Pomeranian dogs regrow hair, but it wasn't linked to estrogen receptors.

research Deslorelin for the treatment of hair cycle arrest in intact male dogs

10 citations , July 2014 in “Veterinary dermatology”

Deslorelin may help intact male dogs regrow hair from alopecia X, with a 75% success rate and no side effects.

research Deslorelin Implant Treatment for Hair Cycle Arrest (Alopecia X) in Two Intact Male Keeshonden

3 citations , May 2018 in “The Journal of the American Animal Hospital Association/Journal of the American Animal Hospital Association”

Deslorelin implants successfully treated hair loss in two male Keeshonden dogs.

research 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia

1 citations , November 2022 in “Journal of Investigative Dermatology”

ALRN-6924 may prevent hair loss caused by chemotherapy.

research The use of photobiomodulation therapy in the treatment of hair cycle arrest in a Pembroke Welsh corgi

February 2022 in “Veterinary record case reports”

Light therapy successfully treated a dog's hair growth problem without side effects.

research Intensive stress impedes hair follicle growth through triggering cell cycle arrest of hair follicle stem cells

March 2025 in “The FASEB Journal”

Intense stress stops hair growth by halting hair follicle stem cell activity.

Temporary Cell Cycle Arrest by ALRN-6924: A Novel P53-Targeting Strategy to Protect Human Scalp Hair Follicles Against Cyclophosphamide-Induced Alopecia

research 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia

April 2023 in “Journal of Investigative Dermatology”

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

research 502 The stress-responsive secretory protein adrenomedullin 2 potently induces cell cycle arrest and apoptosis in human hair follicles

November 2024 in “Journal of Investigative Dermatology”

Adrenomedullin 2 stops cell growth and causes cell death in human hair follicles.

research Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by the Artificial Lipid Barrier

23 citations , March 2017 in “Journal of Investigative Dermatology”

An artificial lipid barrier can restore hair growth in cases of SCD1 deficiency.

Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

research 1367 Inhibition of the mitochondrial pyruvate carrier promotes ATF4–dependent stress responsive metabolic rewiring and cell cycle arrest in the human hair follicle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.

research Evaluation of phenotypic risk indicators for the development of alopecia X (hair cycle arrest) in Pomeranian dogs in the Netherlands and Belgium

2 citations , January 2025 in “Veterinary Dermatology”

Male Pomeranians with woolly coats are more likely to develop alopecia X.

research Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X

18 citations , October 2017 in “PLOS ONE”

The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.

research FGF18 signaling determines radioresistance of telogen hair follicles by the arrest of hair cycling

September 2016 in “Journal of dermatological science”

FGF18 helps hair follicles resist radiation by stopping hair growth cycles.

research Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice

February 2024 in “Journal of Investigative Dermatology”

Deleting NIPP1 in mouse skin cells causes early aging and chronic skin issues.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

130 citations , January 1994 in “Differentiation”

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

research Beyond goosebumps: Does the arrector pili muscle have a role in hair loss?

31 citations , January 2014 in “International Journal of Trichology”

The arrector pili muscle might play a role in hair loss and needs more research to understand its impact.

XMU-MP-1 Induces Growth Arrest in a Model Human Mini-Organ and Antagonizes Cell Cycle-Dependent Paclitaxel Cytotoxicity

research XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity

4 citations , September 2020 in “Cell division”

XMU-MP-1 stops cell growth in a human mini-organ and reduces the effectiveness of the chemotherapy drug paclitaxel.

Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

research Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures

61 citations , September 2010 in “Genomics”

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

research Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation

29 citations , December 2016 in “The EMBO Journal”

Gata6 is important for protecting hair growth cells from DNA damage and keeping normal hair growth.

research Hair fragility (trichorrhexis nodosa) in alopecic Pomeranian dogs

1 citations , September 2024 in “Veterinary Dermatology”

Trichography is important for diagnosing hair fragility in Pomeranian dogs with hair cycle issues.

research Description and characterization of a hair coat disorder in schipperkes

1 citations , December 2018 in “Veterinary dermatology”

The hair coat disorder in Schipperkes is similar to Alopecia X and involves increased androstenedione levels and hair cycle arrest.

research A New Role of Non-Sex Hormone in the Pathogenesis of Female Pattern Hair Loss

August 2025 in “Journal of Investigative Dermatology”

Elevated luteinizing hormone contributes to female-pattern hair loss, and blocking certain channels may help prevent it.

research Cycle pilaire et alopécie X chez le chien

January 2008 in “Pratique médicale & chirurgicale de l'animal de compagnie”

Alopecia X in dogs is a cosmetic issue, not a hormonal disorder, and harmful treatments should be avoided.

research In Vitro and In Vivo Models for the Development of Hair Growth Materials By Regulating the β-Catenin Signaling Pathways

February 2024 in “Journal of medicinal food”

The research found a way to develop hair growth materials by targeting a specific signaling pathway.

research Disrupted citric acid metabolism inhibits hair growth

1 citations , July 2022 in “Journal of dermatology”

Disrupted citric acid metabolism stops hair growth.

research Mild oxidative stress protects against chemotherapy-induced hair loss

2 citations , January 2023 in “Frontiers in Oncology”

Mild oxidative stress can prevent hair loss from chemotherapy.

research The role and mechanism of engineered nanovesicles derived from hair follicle mesenchymal stem cells in the treatment of UVB‐induced skin photoaging

5 citations , May 2024 in “Journal of Cosmetic Dermatology”

Engineered nanovesicles from hair follicle stem cells can effectively treat UVB-induced skin aging.

research Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches

179 citations , April 2012 in “Nature Communications”

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.