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GlossaryHair Cycle Clock

internal mechanism regulating hair growth, rest, and shedding phases

The Hair Cycle Clock refers to the internal biological mechanism that regulates the phases of hair growth, rest, and shedding. This cycle includes the anagen (growth), catagen (transitional), and telogen (resting) phases, ensuring that hair follicles undergo a synchronized process of renewal and shedding. Understanding this clock is crucial for diagnosing and treating hair disorders like alopecia.

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Research

5 / 1000+ results

research Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

116 citations , May 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

research A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

92 citations , September 2013 in “Journal of Investigative Dermatology”

BMAL1 and Period1 genes can influence human hair growth.

Hunting the Hair Cycle Clock: Evidence That Mitochondrially Localized MPZL3 Is a Key Element in Murine and Human Hair Follicles

research 715 Hunting the hair cycle clock (HCC): Evidence that mitochondrially localized MPZL3 is a key HCC element in murine and human hair follicles

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 is important for controlling the hair growth cycle in mice and humans.

research 583 Hair cycle regulation by a mitochondrially localized protein: Is MPZL3 a central component of the elusive hair cycle clock?

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 protein is important for controlling hair growth cycles.

research New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence

68 citations , April 2012 in “Journal of Investigative Dermatology”

The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.

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Community Join

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community Circadian rhythm disruption and its potential impact on hair growth cycles

in Technology 7 upvotes 2 months ago

Poor sleep quality may affect hair growth cycles by disrupting the body's natural clock and stress hormones. The focus should be on improving sleep to support overall health, including hair growth, rather than relying solely on treatments like Minoxidil, finasteride, or RU58841.

community Scalp hydration's surprising link to hair growth cycle regulation

in Technology 23 upvotes 2 months ago

Scalp hydration may influence hair growth by affecting the signaling pathways that control the hair growth cycle. Users suggest using facial moisturizer, aloe vera, and oils for scalp hydration.

community Does periodic shedding make long hair with finasteride impossible?

in Finasteride/Dutasteride 7 upvotes 3 months ago

Finasteride can help extend the hair growth cycle and improve hair density, allowing for long hair despite initial shedding. Periodic shedding may occur, but it typically does not affect healthy hair significantly.

community 11 month progress on a cocktail regiment

in Progress Pictures 440 upvotes 2 years ago

The user "Dismal_Library_2264" shared their 11-month progress on a hair loss treatment regimen. They used dutasteride, topical minoxidil, dermarolling, a hair serum, and specific shampoos. They experienced some side effects but were overall satisfied with the results.

community Long term fin users (3+ years): Do you still shed periodically?

in Finasteride/Dutasteride 26 upvotes 1 year ago

Long-term finasteride users often experience periodic hair shedding due to natural hair cycles, even after several years of use. Some consider switching to dutasteride, but concerns about side effects and the effectiveness of finasteride remain common.

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Learn

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learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn sh-Polypeptide-7

learn Vascular Endothelial Growth Factor

learn Epidermal Growth Factor

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Experts

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