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Immune Checkpoint Inhibitor-Related Alopecia: Insight into the Pathophysiology Using Non-Invasive Diagnostic Techniques

research Immune checkpoint inhibitor‐related alopecia: Insight into the pathophysiology utilizing non‐invasive diagnostic techniques

6 citations , January 2019 in “Journal of dermatology”

Immune checkpoint inhibitors used in cancer therapy can cause hair loss, and understanding this can help manage the side effect.

research A Case Report on Recurrent Trichilemmal Carcinoma of Scalp- Role of Clinico-Radiological Correlation

April 2023 in “International Journal of Medical Science and Clinical Research Studies”

Accurate diagnosis of rare scalp cancer requires combining clinical and radiological information.

research First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

505 citations , October 2011 in “Journal of clinical oncology”

MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.

research K6/ODC transgenic mice as a sensitive model for carcinogen identification

57 citations , July 2000 in “Toxicology Letters”

K6/ODC transgenic mice are effective for quickly identifying cancer-causing chemicals.

research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

54 citations , February 2002 in “Carcinogenesis”

Increasing SSAT makes skin more prone to cancer.

research Regulation of VDR by ΔNp63α is associated with inhibition of cell invasion

34 citations , July 2009 in “Journal of Cell Science”

ΔNp63α helps control a protein that stops cancer cells from spreading.

research A Survey on Health Effects in a Human Population Exposed to Permanent‐Waving Solution Containing Thioglycolic Acid

31 citations , November 2003 in “Journal of Occupational Health”

Thioglycolic acid in hair products may pose reproductive and cancer risks for hairdressers.

research Merkel cell carcinoma: updates in tumor biology, emerging therapies, and preclinical models

17 citations , July 2024 in “Frontiers in Oncology”

New therapies and trials are needed for Merkel cell carcinoma, a tough skin cancer.

research Twist1 is required for the development of UVB‐induced squamous cell carcinoma

11 citations , March 2021 in “Molecular Carcinogenesis”

Twist1 is crucial for UVB-induced skin cancer development.

research Cutaneous transcriptome analysis in NIH hairless mice

7 citations , August 2017 in “PloS one”

Key genes linked to hair growth and cancer were identified in hairless mice.

The Use of Stem Cell Differentiation Stage Factors Taken from Zebrafish Embryos During Organogenesis and Their Role in Regulating Gene Expression of Normal and Pathological Cells

research The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos during Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells

3 citations , July 2020 in “International Journal of Molecular Sciences”

SCDSFs from zebrafish embryos are beneficial for treating cancer, regenerating tissues, and improving conditions like psoriasis and alopecia.

research Clinical Snippets

1 citations , March 2003 in “Journal of Investigative Dermatology”

Early sunburn treatment with certain inhibitors may reduce skin cancer risk.

research Gene Therapy: Recent Advances and Applications in Dermatology

1 citations , October 1996 in “Journal of Cutaneous Medicine and Surgery”

Gene therapy shows promise for treating skin disorders and cancer, but faces technical challenges.

research The role of Twist1 in UVB-induced skin carcinogenesis

December 2020

Deleting Twist1 in skin cells reduces UVB-induced skin cancer risk.

research Abstract 2474: The mechanistic role of polyamines in DNA double-strand break repair

July 2017 in “Cancer Research”

Polyamines help repair DNA breaks and may influence cancer development.

research Snail2: Estudios estructura-función y análisis in vivo de su papel en el desarrollo del folícullo piloso y la carcinogénesis química de la piel

October 2014 in “Dialnet (Universidad de la Rioja)”

Snail2 is crucial for hair growth and affects skin cancer development.

research Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.

January 2009 in “Bradford Scholars (University of Bradford)”

BMP signaling helps prevent skin tumors by blocking cancer-promoting pathways.

research Prodrugs of butyric acid from bench to bedside: Synthetic design, mechanisms of action, and clinical applications

70 citations , January 2000 in “Drug Development Research”

New butyric acid prodrugs show promise for cancer treatment, anemia management, and protecting hair from chemotherapy damage.

research EFFECT OF ESTRADIOL LOCALLY APPLIED TO ABNORMAL SKIN

14 citations , August 1943 in “Archives of Dermatology”

Applying estradiol to skin causes local changes but not cancer.

research A discriminant multi-scale histopathology descriptor using dictionary learning

9 citations , March 2014 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE”

The new image descriptor helps identify skin cancer structures with good accuracy.

research Dasatinib-Induced Leukotrichia in a Patient With Chronic Myelogenous Leukemia

9 citations , May 2013 in “JAMA Dermatology”

A woman's hair turned white after taking a cancer drug called dasatinib.

research Cyclophosphamide-associated acneiform drug eruption in a patient with multiple myeloma

5 citations , August 2011 in “Journal of the American Academy of Dermatology”

A patient's skin eruption was caused by the cancer drug cyclophosphamide and improved after stopping the drug.

research Cytokeratin 19 expression in usual cutaneous carcinomas

January 2003 in “The Chinese Journal of Burns Wounds & Surface Ulcers”

CK 19 expression is higher in more severe skin cancers.

research Vitamin D3 and chemotherapy-induced alopecia

11 citations , June 1996 in “Nutrition”

Vitamin D3 may prevent hair loss from chemotherapy, but side effects and cancer cell protection are concerns.

research Targeting the Wnt pathways for therapies

112 citations , January 2014 in “Molecular and cellular therapies”

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo

52 citations , May 1997 in “Journal of Biological Chemistry”

High ornithine decarboxylase levels may lead to hair loss and cancer by increasing CK2 activity in the nucleus.

research Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic mice

49 citations , August 2004 in “The FASEB Journal”

Mice with human skin protein K8 had more skin problems and cancer.

research Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

31 citations , February 2007 in “Molecular Carcinogenesis”

Overexpressing ATF3 in mice's epithelial cells may lead to oral cancer.

research Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

29 citations , October 2016 in “Cell death and differentiation”

ΔNp63α stops TAp73β from working in skin cancer by blocking its access to specific genes, not by directly interacting with it.

research Prevention of chemotherapy-induced alopecia in rodent models

27 citations , March 2008 in “Cell stress & chaperones”

Localized heat or specific injections can prevent chemotherapy-induced hair loss without affecting cancer treatment.

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