research Investigation of Children's Hair Lead Level and Its Effect of Healthy in A Lead-Zinc Mine
Lead pollution from the mine harms children's IQ, growth, and health.
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research Moving Beyond Boundaries: Utilization of Longitudinal Exposure–Response Model for Bounded Outcome Score to Inform Decision Making in the Accelerated Drug Development Paradigm
The study utilized a model-informed drug development approach to evaluate the efficacy of ritlecitinib, a JAK3/TEC family kinases inhibitor, in treating alopecia areata, using data from 1,268 patients across phase 2b and 3 trials. The longitudinal exposure-response model effectively described the Severity of Alopecia Tool (SALT) score profile, identifying disease severity as the sole covariate impacting efficacy. It demonstrated that temporary treatment interruptions of up to 6 weeks do not significantly affect efficacy, while longer interruptions could lead to substantial hair regrowth loss. The study found that a 50 mg once-daily dose was effective, with higher doses approaching maximum efficacy. The model's predictive performance was validated, supporting dose selection and trial strategies, and offering a framework applicable to other conditions measured on a bounded scale.
research Attention Balanced Multi-Dimension Multi-Task Deep Learning for Alopecia Recognition
The new deep learning system can accurately recognize hair loss conditions with a 95.11% success rate.
research Quality of life assessment in patients with alopecia areata and androgenetic alopecia in the People’s Republic of China
Hair loss from alopecia areata and androgenetic alopecia moderately affects the quality of life, especially in younger patients and those with long-term hair loss, impacting both their physical and emotional well-being.
research Endocrine Therapy–Induced Alopecia in Patients With Breast Cancer
Hair loss from hormone therapy in breast cancer patients can be improved with minoxidil treatment.
research RỤNG TÓC VÀ SỨC KHỎE TÂM THẦN: MỐI LIÊN HỆ HAI CHIỀU VỚI LO ÂU, MẤT NGỦ VÀ CHẤT LƯỢNG CUỘC SỐNG
Hair loss and mental health issues like anxiety and insomnia affect each other, impacting quality of life.
research The psychosocial burden of androgenetic alopecia in Saudi Arabia: A cross-sectional study
Hair loss in Saudi Arabia causes a low psychosocial impact, with less effect on those without a family history of hair loss.
research Prevalence of androgenic alopecia (AGA) in patients with polycystic ovarian syndrome (PCOS) and characterization of associated clinical and biochemical features
Hair loss is common in women with PCOS and is linked to symptoms like acne and excess hair but not to worse metabolic health.
research Alopecia areata
Baricitinib shows promise for severe alopecia areata but isn't a cure and has side effects.
research Evaluating the hair regenerative potential of plant-based hair serum formulation: a comparative study
The plant-based hair serum is a promising and safe alternative to minoxidil for hair regrowth.
research Comparative Efficacy and Safety of Baricitinib Against Traditional Therapies in Severe Alopecia Areata: A Retrospective Cohort Study
Baricitinib is effective for severe alopecia areata but has some side effects.
research Evaluation of the Efficacy and Safety of Oral Tofacitinib for the Treatment of Alopecia Areata in Children
Tofacitinib effectively reduces hair loss in children with alopecia areata but may cause mild side effects and relapses.
research Adolescent Male Androgenetic Alopecia with Iron Deficiency Anemia: A Case Treated with Individualized Homeopathy
Homeopathy may help treat hair loss and improve quality of life.
research Beneficial effect of spironolactone on androgenic alopecia
Spironolactone may help reduce hair loss in androgenic alopecia.
research Bimatoprost
Bimatoprost may help treat hair loss from alopecia areata.
research The efficacy of scalp cooling in patients receiving chemotherapy for primary gynecologic cancers: a randomized controlled trial
Scalp cooling reduces hair loss and improves quality of life during chemotherapy.
research Real‐life effectiveness and safety of baricitinib in adults with alopecia areata: A multicentre study
Baricitinib effectively reduces hair loss in alopecia areata and is well-tolerated.
research Androgenic Alopecia Is Associated With More Severe Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
People with hair loss may have worse urinary symptoms due to an enlarged prostate.
research A Chance Finding of High Grade Prostate Cancer in a 35-Year-Old Male – A Case Report and Outcomes of Robotic Radical Prostatectomy in Young Men with Prostate Cancer
A young man with high-grade prostate cancer had successful surgery and good recovery, highlighting the need for awareness in younger men.
research Associated Factors of Quality of Life in Adult Female Acne Coexisting with Hyperandrogenism and Polycystic Ovarian Syndrome using the Dermatology Life Quality Index
Acne and hair loss in women can greatly lower their quality of life, but having polycystic ovarian syndrome does not.
research Alopecia Universalis: an extremely rare but probable adverse effect of adalimumab
Adalimumab can cause complete hair loss in rare cases.
research Dermatology Life Quality Index in Thai Male Androgenetic Alopecia Patients attending Dermatology Outpatient Clinic
Younger men with hair loss have a worse quality of life.
research A Case Study of Androgenetic Alopecia in woman Improved by Pharmacopuncture Therapy and Needle-embedding Therapy
The woman's hair loss improved significantly after treatment with acupuncture, pharmacopuncture, and needle-embedding therapy.
research Evaluation of Sexual Function With an International Index of Erectile Function in Subjects Taking Finasteride for Androgenetic Alopecia
Finasteride for hair loss doesn't harm erectile function; weight loss and exercise improve it.
research Long-Term Efficacy of Ritlecitinib up to Month 24 From the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata
Ritlecitinib is effective for long-term treatment of severe alopecia areata.
research Topical tofacitinib for patients with lichen planopilaris and/or frontal fibrosing alopecia
Topical tofacitinib cream may help treat certain hair loss conditions with fewer risks.
research Efficacité à long terme du baricitinib dans le traitement de la pelade : résultats à la semaine 104 des études BRAVE-AA1 et BRAVE-AA2
Baricitinib effectively treats severe alopecia for up to 104 weeks.
research Retrospective Analysis of Pediatric Alopecia Areata Treated with Methotrexate
Methotrexate may effectively and safely treat hair loss in children, with notable improvement after 12-15 months.
research 706 Predictive modeling of patient response to JAK/STAT inhibitors and dynamic patient-matching
Machine learning can predict how well patients with alopecia areata will respond to certain treatments.
research Systems pharmacology identifies dermal papilla–specific transcriptomic reversal of androgenetic alopecia by lithium–zinc pathway convergence
Lithium and zinc together may help reverse hair loss by targeting specific cells.