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GlossaryHEI-OC1 cells

immortalized mouse inner ear cells used for auditory research

HEI-OC1 cells are a type of immortalized cell line derived from the inner ear of mice, specifically used for research on hearing and auditory function. These cells are valuable in scientific studies because they can proliferate indefinitely and are used to investigate the mechanisms of hearing loss, drug ototoxicity, and potential treatments for auditory disorders.

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Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

research Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway

5 citations , November 2022 in “Molecular Neurobiology”

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

Deferoxamine Protects Cochlear Hair Cells Against Tert-Butyl Hydroperoxide-Induced Ototoxicity

research Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity

March 2024 in “Biochimica et biophysica acta. Molecular basis of disease”

Deferoxamine may help protect inner ear cells from damage caused by oxidative stress.

research Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway

5 citations , November 2021 in “Frontiers in Cell and Developmental Biology”

Caffeine can damage hearing cells and affect hearing recovery after ear trauma.

research 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway

1 citations , March 2024 in “Journal of Cellular and Molecular Medicine”

4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.

research Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways

May 2024 in “Biochemical pharmacology”

Blocking CISD1 reduces hearing loss from cisplatin in mice.

Melatonin Protects Cochlear Hair Cells from Nicotine-Induced Injury Through Inhibiting Apoptosis, Inflammation, Oxidative Stress, and Endoplasmic Reticulum Stress

research Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress

5 citations , July 2021 in “Basic & Clinical Pharmacology & Toxicology”

Melatonin may protect ear cells from damage caused by nicotine.

research CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress

4 citations , August 2023 in “Biomedicine & Pharmacotherapy”

Ivacaftor can protect against noise-induced hearing loss by reducing oxidative stress.

research Hair cell toxicology: With the help of a little fish

4 citations , December 2022 in “Frontiers in cell and developmental biology”

Zebrafish larvae are used to study and find treatments for ear cell damage because they are easier to observe and test than mammals.

research Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

26 citations , October 2023 in “Neuroscience Bulletin”

Stem cell therapy could help regenerate inner ear hair cells to treat hearing loss.

research Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

39 citations , December 2011 in “PLoS ONE”

Radiofrequency exposure can stimulate hair growth by increasing IGF-1 in hair follicle cells.

research Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation

2 citations , January 2023 in “Redox Report”

Estradiol may protect ear cells from hearing loss caused by a chemotherapy drug by activating a protective pathway.

research MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation

January 2024 in “Biological Research”

Tiny particles from stem cells can help protect ear cells from antibiotic damage by helping cells remove damaged parts.

research XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

January 2026 in “Advanced Science”

Increasing XIAP and DDRGK1 can help prevent hearing loss from loud noise.

research The Role of Nrf2 in Hearing Loss

17 citations , April 2021 in “Frontiers in Pharmacology”

Activating Nrf2 can help protect against hearing loss.

research Modern drug delivery strategies applied to natural active compounds

39 citations , September 2016 in “Expert Opinion on Drug Delivery”

New drug delivery methods can make natural compounds more effective and stable.

research Methods and Challenges in Purifying Drug‐Loaded Extracellular Vesicles

15 citations , June 2025 in “Journal of Extracellular Vesicles”

Standardized guidelines are needed to improve drug-loaded extracellular vesicle purification.

research Associations of dietary indices with risk of all-cause and cardiovascular mortality in hypertensive adults

3 citations , November 2025 in “Annals of Medicine”

Following the DASH diet reduces mortality risk in hypertensive adults.

research Population and Individual Stem Cell Dynamics in the Olfactory Epithelium

January 2016 in “eScholarship (California Digital Library)”

HBCs in the olfactory epithelium can self-renew or differentiate into other cell types, with specific patterns during regeneration.

research Hair Follicle Pluripotent Stem (hfPS) Cells

2 citations , January 2009 in “Human cell culture”

ZO-1 Boosts the In Vitro Self-Renewal of Pre-Haematopoietic Stem Cells from OCT4-Reprogrammed Human Hair Follicle Mesenchymal Stem Cells Through Cytoskeleton Remodeling

research ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling

December 2024 in “Stem Cell Research & Therapy”

ZO-1 helps hair follicle stem cells renew better by changing their structure.

research Author response: Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

1 citations , May 2020

Four transcription factors can convert mouse cells into hair cell-like cells, aiding hearing loss research and treatment.

research 0163 Specific targeting of dermal papilla cells with Hhip-Cre

July 2025 in “Journal of Investigative Dermatology”

research 895 Isoproterenol directs human hair follicle-associated pluripotent (hHAP) stem cells to differentiate to cardiac muscle cells

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human hair follicles can be used to create heart muscle cells.

research Transcriptional profiling of putative human epithelial stem cells

16 citations , July 2008 in “BMC Genomics”

Alpha 6 + /MHCI - cells have stem cell traits and are similar to mouse hair follicle stem cells.

Oxytocin Receptor Expression in Hair Follicle Stem Cells: A Promising Model for Biological and Therapeutic Discovery in Neuropsychiatric Disorders

research OXYTOCIN RECEPTOR EXPRESSION IN HAIR FOLLICLE STEM CELLS: A PROMISING MODEL FOR BIOLOGICAL AND THERAPEUTIC DISCOVERY IN NEUROPSYCHIATRIC DISORDERS

October 2023 in “IBRO neuroscience reports”

Rat hair follicle stem cells have functional oxytocin receptors, useful for studying neuropsychiatric disorders.

research Human Epidermal Neural Crest Stem Cells (hEPI-NCSC)—Characterization and Directed Differentiation into Osteocytes and Melanocytes

91 citations , March 2011 in “Stem Cell Reviews and Reports”

Human epidermal neural crest stem cells can become bone and skin pigment cells, making them useful for therapies.

research Defining compartmentalized stem and progenitor populations with distinct cell division frequency in the ocular surface epithelium

June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Stem and progenitor cells in the eye have different division rates and locations, affecting how they respond to injury.