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360-390 / 1000+ resultsresearch Cutaneous hydroxystereoid dehydrogenases and rat-hair-cycle
Certain enzymes react strongly with some hormones in rat skin during hair growth, mainly in sebaceous glands and hair sheaths.
research VIBRATIONAL SPECTROSCOPIC INVESTIGATION AND MOLECULAR STRUCTURE OF A 5α-REDUCTASE INHIBITOR: FINASTERIDE
Finasteride's molecular properties and active sites were identified using computational methods.
research Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs
research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro
11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.
research Release systems based on self-assembling RADA16-I hydrogels with a signal sequence which improves wound healing processes
Self-assembling RADA16-I hydrogels with bioactive peptides significantly improve wound healing.
research Bioinspired multifunctional injectable hydrogel for hemostasis and infected wound management
The hydrogel quickly stops bleeding and helps heal infected wounds.
research A mechanical-assisted post-bioprinting strategy for challenging bone defects repair
The new method improves bone repair by enhancing cell loading and stability in bioprinted scaffolds.
research Improved synthesis of finasteride
The new method makes finasteride production cheaper and safer for industry.
research Discovery of a novel hybrid from finasteride and epristeride as 5α-reductase inhibitor
New hybrid compound found to effectively prevent hair loss.
research Data-driven strategies for drug repurposing: insights, recommendations, and case studies
Drug repurposing can speed up and reduce costs in drug discovery, especially for cancer treatment.
research AcD : A Novel Bioactive Polymer Scaffold of Adipose‐Derived Stem Cells Combining With Decellularized Extracellular Matrix in Tissue Engineering
AcD scaffolds improve tissue repair and regeneration by combining stem cells with a supportive matrix.
research A computer‐aided drug repurposing: the antibacterial agents targeting GroEL
Daprodustat, combined with PAβN, could be a new antibacterial treatment.
research B/N-doped carbon nano-onions as nanocarriers for targeted breast cancer therapy
Boron/nitrogen-doped carbon nano-onions improve targeted breast cancer treatment by enhancing drug delivery and reducing side effects.
research Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase
LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.
research The walking dead: sequential nuclear and organelle destruction during hair development
Cells in hair die by breaking down their DNA and mitochondria as they form keratin.
research Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application
Polymers can be designed to mimic natural cell environments for medical uses.
research Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
Histone demethylases can change gene expression and may be linked to diseases like cancer.
research Finasteride/spironolactone
research The Trilogy of Skin Regeneration via Metal-Organic Frameworks Nanomedicine: Precision Management of Refractory Wounds, Pathological Scarring, and Hair Follicle Reactivation
Metal-organic frameworks can help heal wounds, reduce scars, and promote hair growth, but more research is needed.
research 5α-Reductases In Human Physiology: an Unfolding Story
We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
research Development of 3-D Microbioreactor Systems for Cell-Based High Throughput Screening
A new 3-D bioreactor system improves drug screening and reduces animal testing.
research Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process
Changing the 6-position on benzopyran molecules affects insulin release, with some compounds showing strong inhibitory effects.
research Reaction of Finasteride Intermediate with Benzeneseleninic Anhydride: An In-Depth Study
Impure benzeneseleninic anhydride samples cause lower finasteride intermediate yields.
research Hydrogel Composites for Multifunctional Biomedical Applications
Hydrogel composites have great potential in regenerative medicine, tissue engineering, and drug delivery.
research Hydrogel Lego based on rehydrated laminate assembly for standardized production and customized integration of multifunctional hydrogel sensors
New hydrogel sensors can be quickly made and customized for wearable devices.
research Miscellaneous Steroids
The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.
research Novel recombinant human acid α-glucosidase with optimal glycosylation is significantly better than standard of care enzyme replacement for glycogen clearance in skeletal muscles of GAA knock-out mice
research Cytotoxic Effect of YH239-EE and Its Enantiomer on MCF7 Cell Line
The (+) enantiomer of YH239-EE effectively kills breast cancer cells.
research New 5?-reductase inhibitors: In vitro and in vivo effects
Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.