research FRI-02 FROM GIRLS TO BOYS TO OLDER MEN, THE INTERESTING TALE OF THE GUEVEDOCES AND 5-ALPHA REDUCTASE INHIBITORS
The discovery of 5α-reductase deficiency in guevedoces led to the development of important urologic medications.
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570-600 / 1000+ resultsresearch More than One Gene Involved in Monilethrix: Intracellular but also Extracellular Players
Monilethrix involves multiple genes affecting hair structure, including DSG4 mutations.
research Organoid‐Guided Precision Medicine: From Bench to Bedside
Organoid technology is improving personalized medicine by better predicting drug responses and treatments.
research Sequential estrogen-progestin addition to gonadotropin-releasing hormone agonist suppression for the chronic treatment of ovarian hyperandrogenism: a pilot study.
The treatment effectively reduced hair growth and was safe for patients with PCOS, but it needs better bleeding control.
research Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
Multitarget drugs are needed to better treat complex diseases.
research DIFFERENT HORMONAL PATTERNS IN PREP'UBERTAL HYPERTRICHOSIS
research Cortexolone 17a-propionate: A new antiandrogen acting on hair dermal papilla cells for the treatment of androgenic alopecia
Cortexolone 17a-propionate may be an effective new treatment for hair loss.
research Molecular Interactions of New Pregnenedione Derivatives
The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
research 5 Alpha-reductase inhibitors: whatʼs new?
A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.
research Autotaxin–lysophosphatidic acid– LPA 3 signaling at the embryo‐epithelial boundary controls decidualization pathways
LPA3 signaling in the uterus is crucial for placental formation and fetal development.
research Exposure of Xenopus laevis tadpoles to finasteride, an inhibitor of 5-α reductase activity, impairs spermatogenesis and alters hypophyseal feedback mechanisms
Finasteride exposure harms tadpole reproduction and hormone balance.
research Genetic Ablation of the CDP/Cux Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility
Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.
research 25 years of ERβ: a personal journey
ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.
research Mapping the expression of epithelial hair follicle stem cell‐related transcription factors LHX 2 and SOX 9 in the human hair follicle
LHX2 and SOX9 identify unique hair follicle cell groups, crucial for hair maintenance.
research The Art of Mixing Follicular Units and Follicular Groupings in Hair Restoration Surgery
A hair restoration technique was introduced that mixes different types of hair groupings to reduce procedure time, limit damage, and potentially increase hair density, suggesting more hair can be transplanted than previously thought.
research Two Cases of Paradoxical Nonscarring Alopecia after Mesotherapy with Dutasteride
Two people lost hair unexpectedly after getting a common hair loss treatment with a drug called Dutasteride.
research The disrupted balance between hair follicles and sebaceous glands inHoxc13‐ablated rabbits
Rabbits lacking the Hoxc13 gene show similar hair and skin issues to humans with ECTD-9, making them good for research on this condition.
research Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases
Neural organoids show promise for future CNS disease treatments.
research Open and Closed Structure
The 3D hair follicle model improves understanding of hair growth and drug testing.
research Core–Sheath Nanofibers From a Modified Coaxial Electrospinning for Transdermal Delivery of Finasteride
This study presents a modified coaxial electrospinning approach to create core-sheath nanofibers for enhanced transdermal delivery of finasteride (FIN). By using an electrospinnable ethylcellulose solution with FIN as the core and an unspinnable polyvinylpyrrolidone/sodium dodecyl sulfate solution as the sheath, the researchers fabricated robust medicated nanofibers (E3). Compared to traditional monolithic nanofibers (E2), the E3 nanofibers demonstrated improved FIN penetration rates, with significant differences observed from initial tests at 0.5 hours (10.32% for E2 and 12.85% for E3) to final tests at 4.0 hours (38.16% for E2 and 51.31% for E3). The study suggests that the unspinnable sheath fluid prevents abnormal phenomena in single-fluid processes, offering a strategy to enhance the performance of traditional electrospinning products.
research A 5α-reductase inhibitor, finasteride, increases differentiation and proliferation of embryonal carcinoma cell-derived-neural cells
research Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles
A new method improves the isolation of hair follicle cells for better hair growth research.
research High-performance liquid chromatographic determination of finasteride in human plasma using direct injection with column switching
New method detects finasteride in plasma quickly and accurately without clean-up.
research Dual‐flow‐RootChip reveals local adaptations of roots towards environmental asymmetry at the physiological and genetic levels
Roots adapt to uneven environments by changing growth and gene expression.
research (Un)targeted Scanning of Locks of Hair for Drugs of Abuse by Direct Analysis in Real Time–High-Resolution Mass Spectrometry
A new method can quickly and accurately detect drugs in hair.
research Loss-of-Function Mutations in HOXC13 Cause Pure Hair and Nail Ectodermal Dysplasia
Mutations in the HOXC13 gene cause hair and nail development issues.
research K6/ODC transgenic mice as a sensitive model for carcinogen identification
K6/ODC transgenic mice are effective for quickly identifying cancer-causing chemicals.
research High-content drug screening for rare diseases
High-content screening is useful for finding new treatments for rare diseases and has led to FDA-approved drugs.
research Three-dimensional modelling of interchain sequence similarities and differences in the coiled-coil segments of keratin intermediate filament heterodimers highlight features important in assembly
Keratin heterodimers are preferred for their specific and structural advantages.
research Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits
A brain-made hormone can protect against memory-related brain damage caused by harmful proteins.