research Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors
Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.
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120-150 / 1000+ resultsresearch Skin regional specification and higher-order HoxC regulation
A specific DNA duplication in Polish chickens affects feather shape by altering gene expression.
research Roles for Msx and Dlx homeoproteins in vertebrate development
Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.
research Metabolic study of androsta-1,4,6-triene-3,17-dione in horses using liquid chromatography/high resolution mass spectrometry
The study found that urine metabolites M1b or M4 are the best indicators of ATD use in horses, with detection possible up to 77 hours in urine and 28 hours in blood.
research AN EFFICIENT SYNTHESIS OF DUTASTERIDE: UTILIZING BENZOYL GROUP AS NOVEL LACTAMIC PROTECTING GROUP
Researchers created a new, efficient way to make Dutasteride, a hair loss and prostate drug, with high purity using a benzoyl group.
research Evaluation of bioequivalence of five 0.1 mg dutasteride capsules compared to one 0.5 mg dutasteride capsule: a randomized study in healthy male volunteers
Taking five small dutasteride capsules is the same as taking one larger capsule.
research HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond
Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.
research Discovery of an Androgen Receptor Degrader Featuring a Pyridazinyl Glutarimide CRBN-Binding Motif for Transdermal Treatment of Androgenetic Alopecia
dAR-6–1 is a promising new treatment for hair loss that works better than minoxidil.
research Effects of 2-Ethylhexanoic Acid on Reproduction and Postnatal Development in Wistar Rats
2-Ethylhexanoic acid harms fertility and delays development in rats.
research Mechanisms of Action of Dehydroepiandrosterone
DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.
research New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors
New compounds may help treat prostate issues without affecting androgen receptors.
research Chronic exposures to the herbicide atrazine and the pharmaceutical finasteride disrupt sex steroid and thyroid hormone signalling and gonadal development in frogs
Atrazine and finasteride disrupt hormone signaling and affect frog development.
research Lipid Profile and 5α-Reductase Inhibition Activity of Proprietary Ultrahigh-Pressure Supercritical Carbon Dioxide and Hexane Saw Palmetto Extracts
UHP-sCESr is as effective as HESr for treating BPH symptoms.
research METABOLISM OF DEHYDROEPIANDROSTERONE BY ISOLATED HUMAN HAIR FOLLICLES
Human hair follicles can process steroid hormones like DHEA.
research Simultaneous determination of multi-class active pharmaceutical ingredients by UHPLC-HRMS
A new method was developed to accurately detect and measure 47 different drug ingredients in various products.
research 13C-NMR study of 4-azasteroids in solution and solid state
4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.
research Engineering Human Skin with Spatially Defined Hair Peg-Like Structures Using Self-Organizing Composite Organoids and Micropatterned Dermal Scaffolds
research Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol
Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.
research AcD : A Novel Bioactive Polymer Scaffold of Adipose‐Derived Stem Cells Combining With Decellularized Extracellular Matrix in Tissue Engineering
AcD scaffolds improve tissue repair and regeneration by combining stem cells with a supportive matrix.
research Integument pattern formation involves genetic and epigenetic controls: feather arrays simulated by digital hormone models.
Feather patterns form through genetic and epigenetic controls, with cells self-organizing into periodic patterns.
research The ultrastructure of the interfollicular epidermis of the hairless (hr/hr) mouse
research Identification of a Rare Variant in the SRD5A2 Gene in Siblings With 46,XY Disorders of Sexual Development
A rare gene variant causes sexual development issues in siblings, needing personalized treatment.
research Bicalutamide
research Enrichment and characterization of human dermal stem/progenitor cells using collagen type IV
Scientists identified a group of human skin cells with high growth and regeneration potential.
research In Vivo Follicular Unit Multiplication: Is It Possible to Harvest an Unlimited Donor Supply?
It's not possible to get unlimited hair for transplants from the same donor area.
research A Mechanical-assisted Post-bioprinting Strategy for Challenging Bone Defects Repair
The new method improves bone repair by enhancing cell loading and stability in bioprinted scaffolds.
research Multiple cell types guided by neurocytes orchestrate horn bud initiation in dairy goats
Nerve cells and other cell types work together to start horn growth in dairy goats.
research Functional redundancy of Frizzled 3 and Frizzled 6 in planar cell polarity control of mouse hair follicles
Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.
research Allosteric interactions prime androgen receptor dimerization and activation
Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.
research Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin
DHEA acts like a male hormone on rat skin glands and doesn't turn into female hormones there.