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research Elevated Circulation Levels of an Antiangiogenic SERPIN in Patients with Diabetic Microvascular Complications Impair Wound Healing through Suppression of Wnt Signaling

74 citations , January 2014 in “Journal of Investigative Dermatology”

High kallistatin levels in diabetics worsen wound healing by blocking important cell signals.

research Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.

79 citations , October 2003 in “PubMed”

Overexpression of PKCepsilon leads to increased TNFalpha, promoting metastatic squamous cell carcinoma in mice.

research Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2

35 citations , January 2006 in “Cancer Research”

Mice with extra PKCδ resist chemical-induced skin cancer but not UV-induced.

research [An immunohistochemical study on the normal human skin using an anti-hair keratin monoclonal antibody (HKN-2)].

February 1985 in “PubMed”

research Novel and established potassium channel openers stimulate hair growth in vitromodes of action in hair follicles.: implications for their

January 2005

Potassium channel openers like minoxidil boost hair growth.

research Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways

3 citations , September 2024 in “International Journal of Molecular Sciences”

Mathematical modeling helps understand and predict the MAPK cell signaling pathway.

Multicentric Parallel Phase II Trial of the Polo-Like Kinase 1 Inhibitor BI 2536 in Patients With Advanced Head and Neck Cancer, Breast Cancer, Ovarian Cancer, Soft Tissue Sarcoma, and Melanoma. The First Protocol of the European Organization for Research and Treatment of Cancer Network of Core Institutes

research Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)

93 citations , May 2010 in “European Journal of Cancer”

BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.

research LHX2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth

43 citations , January 2016 in “Development”

LHX2 is essential for hair follicle development, controlled by NF-κB and TGFβ2 signaling.

research A WWP2–PTEN–KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice

9 citations , July 2022 in “Journal of Biological Chemistry”

WWP2 is crucial for tooth development in mice.

A Keratinocyte-Specific Epoxygenase, CYP2B12, Metabolizes Arachidonic Acid with Unusual Selectivity, Producing a Single Major Epoxyeicosatrienoic Acid

research A Keratinocyte-specific Epoxygenase, CYP2B12, Metabolizes Arachidonic Acid with Unusual Selectivity, Producing a Single Major Epoxyeicosatrienoic Acid

58 citations , April 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

research Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair

19 citations , August 2023 in “Experimental & Molecular Medicine”

Blocking CXXC5 speeds up diabetic wound healing by improving blood vessel growth and skin repair.

research 102 EZH2 is required for human hair follicle growth and epidermal differentiation

August 2016 in “Journal of Investigative Dermatology”

EZH2 is essential for hair growth and skin cell development.

research ROR2 regulates self-renewal and maintenance of hair follicle stem cells

16 citations , August 2022 in “Nature Communications”

ROR2 is essential for hair follicle stem cell renewal and maintenance.

research Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells

January 2004 in “Pharmaceutical biotechnology”

Finasteride effectively inhibits the enzyme steroid 5 alpha-reductase II.

research Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development

6 citations , June 2021 in “Developmental biology”

Dermal EZH2 controls skin cell development and hair growth in mice.

research Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases

88 citations , August 2019 in “Frontiers in immunology”

Tyrosine kinases are important in skin autoimmune diseases and could be targets for new treatments.

research Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways

10 citations , May 2012 in “Cell Adhesion & Migration”

ILK and ELMO2 help cells move and stick together, important for wound healing and hair growth.

research Potassium channel conductance as a control mechanism in hair follicles

42 citations , July 1993 in “Journal of Investigative Dermatology”

research Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt^WT mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research BMP2-mediated PTEN enhancement promotes differentiation of hair follicle stem cells by inducing autophagy

24 citations , September 2019 in “Experimental cell research”

BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.

research Chaperones as thermodynamic sensors

August 2013 in “Nature Reviews Drug Discovery”

New cancer treatments show promise in reducing tumor growth and improving skin regeneration in mice.

research PNKP is required for maintaining the integrity of progenitor cell populations in adult mice

3 citations , July 2021 in “Life science alliance”

PNKP is essential for keeping adult mouse progenitor cells healthy and growing normally.

CPK1 Activates CNGCs Through Phosphorylation for Calcium Signaling to Promote Root Hair Growth in Arabidopsis

research CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis

January 2025 in “Nature Communications”

CPK1 helps root hair growth in Arabidopsis by activating channels for calcium signaling.

research Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice.

79 citations , June 1993 in “Molecular and Cellular Biology”

The K5 promoter controls gene expression in skin cells, with specific DNA segments crucial for targeting and regulation.

research Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development

19 citations , April 1999 in “British Journal of Dermatology”

Keratin 2e shows a unique pattern in developing fetal skin, different from other keratins.

research Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2

22 citations , August 2015 in “PloS one”

Keratin from hair binds well to gold and BMP-2, useful for bone repair.

research 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model

July 2022 in “Journal of Investigative Dermatology”

Inhibiting TYK2 can restore hair growth in alopecia areata.

research Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration

August 2015 in “PubMed Central”

Epithelial-derived Pop-Up Keratinocytes (ePUKs) may enhance wound healing in regenerative medicine.

research KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis

13 citations , March 2021 in “British Journal of Pharmacology”

KY19382 helps regrow hair and create new hair follicles.

research Dehydroepiandrosterone- and glucose-6-phosphate-dehydrogenases in the hair cycle of the rat

7 citations , January 1971 in “Archives of Dermatological Research”

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