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research Faculty Opinions recommendation of Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells.

October 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Researchers developed a method to label and study human hair follicle stem cells using a fluorescent protein.

research Potential roles of FGF5 as a candidate therapeutic target in prostate cancer.

2 citations , January 2023 in “PubMed”

Targeting FGF5 could help treat prostate cancer.

research Order from disorder: Self-organization in mammalian hair patterning

91 citations , December 2006 in “Proceedings of the National Academy of Sciences”

Hair patterns in mice are controlled by both a global system dependent on Fz6 and a local self-organizing system.

research The presence of glycoproteins in the cell membrane complex of a variety of keratin fibres

29 citations , July 1991 in “Biochimica et Biophysica Acta (BBA) - General Subjects”

Glycoproteins are present in the cell membranes of various keratin fibers.

research Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin

48 citations , April 2008 in “Human Molecular Genetics”

Progerin affects cell shape but not hair or skin in mice.

research Fibroblast Growth Factors in Epithelial Homeostasis and Repair

December 2016

Fibroblast Growth Factors (FGFs) help maintain and repair skin tissues, which is important for preventing diseases like inflammation, fibrosis, and cancer.

research Fine Structure of the Fully Keratinized Hair Cuticle in the Head Hair of the Human

11 citations , January 1981 in “Cells Tissues Organs”

Human hair cuticle has five cell layers with specific junctions and granules.

research Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle

112 citations , August 1984 in “Journal of Investigative Dermatology”

research Transcriptional profiling of putative human epithelial stem cells

16 citations , July 2008 in “BMC Genomics”

Alpha 6 + /MHCI - cells have stem cell traits and are similar to mouse hair follicle stem cells.

research Decision letter: Coordinated hedgehog signaling induces new hair follicles in adult skin

May 2019

Hedgehog signaling can create new hair follicles but may also cause tumors.

research Hair Histology and Glycosaminoglycans Distribution Probed by Infrared Spectral Imaging: Focus on Heparan Sulfate Proteoglycan and Glypican-1 during Hair Growth Cycle

9 citations , January 2021 in “Biomolecules”

Infrared spectral imaging can map hair growth proteins and sugars without staining.

In Vitro Cultured Human-Derived HFMSCs Show Potential to Promote Wound Healing

research In vitro cultured human-derived HFMSCs have shown the potential to promote wound

January 2026 in “China National GeneBank DataBase”

Human hair follicle stem cells can help heal wounds faster.

Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen ( HLA ) in 13 cases of familial frontal fibrosing alopecia: CYP 21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA ‐ A33:01 ; B14:02; C*08:02 as a genetic marker

7 citations , January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

research A Dispute Between the Cavendish and Caltech: The Emergence and Ubiquity of the α‎-Helix

February 2020 in “Oxford University Press eBooks”

The alpha-helix was confirmed as a key structure in proteins.

research Engineering Human Skin with Spatially Defined Hair Peg-Like Structures Using Self-Organizing Composite Organoids and Micropatterned Dermal Scaffolds

January 2026 in “SSRN Electronic Journal”

Faculty Opinions Recommendation of Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo

research Faculty Opinions recommendation of Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.

September 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Lymphatic vessels and hair follicles interact and may influence hair growth.

research LHX2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth

43 citations , January 2016 in “Development”

LHX2 is essential for hair follicle development, controlled by NF-κB and TGFβ2 signaling.

research Recent Advances in the Role of Fibroblast Growth Factors in Hair Follicle Growth

August 2025 in “Biomolecules”

Fibroblast growth factors could be a better, safer treatment for hair loss than current options.

research Fibroblast Growth Factor Influences the Development and Cycling of Murine Hair Follicles

58 citations , April 1993 in “Developmental Biology”

bFGF delays hair growth in mice.

research Sequences and differential expression of three novel human type-II hair keratins

61 citations , February 1997 in “Differentiation”

Hair differentiation starts earlier than thought, involving multiple type-II keratins.

research 684 TGF-β signaling during the early phase of regeneration is required for wound-induced hair follicle neogenesis

July 2024 in “Journal of Investigative Dermatology”

TGF-β signaling is essential for new hair growth after a wound.

research Apoptosis and keratin intermediate filaments

180 citations , April 2002 in “Cell Death and Differentiation”

research Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation

28 citations , August 1992 in “Differentiation”

A new pair of mouse keratins, 65 kD and 48 kD, are found in specific skin areas and are linked to a unique skin differentiation type.

research Heterotypic cell contacts and basal lamina morphology during hair follicle development in the mouse: a light, scanning, and electron microscopic study at the site of tissue interaction

13 citations , December 1983 in “Canadian journal of zoology”

Heterotypic cell contacts likely help hair matrix cells differentiate during mouse hair follicle development.

research Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21

37 citations , January 1993 in “Journal of Investigative Dermatology”

The Hair Follicle: Functions, Self-Renewal, and Alopecic Disorders

research The Hair Follicle

28 citations , March 2016 in “Toxicologic pathology”

Dogs could be good models for studying human hair growth and hair loss.

research <p class="MsoNormal" style="margin-bottom: 12.0pt; text-align: left; mso-line-height-alt: 14.0pt; layout-grid-mode: char; mso-layout-grid-align: none;" align="left">Discovery of Four New<em> FGF5</em> Variants Causing Long Hair in the Dog

January 2026 in “Preprints.org”

Four new FGF5 gene variants cause long hair in dogs.

research In vitro assembly properties of human type I and II hair keratins

1 citations , January 2014 in “Medical Entomology and Zoology”

research EXPRESSION CHARACTERISTICS OF bFGF, EGF, TGF-β ISOFORMS AND THEIR RECEPTORS IN SKIN FROM FETUS AND ADULT

January 2003 in “Jiefangjun yixue zazhi”

Growth factors in skin increase with age, aiding development and healing.

research Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture

2 citations , February 2024 in “Nature cell biology”

Mechanical forces are crucial for shaping cells and forming tissues during development.

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