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GlossaryHigh-Fat Diet

diet high in fats, often over 35-40% of calories

A High-Fat Diet (HFD) is a dietary regimen where a significant portion of daily caloric intake comes from fats, often exceeding 35-40% of total calories. This type of diet is commonly used in research to study metabolic disorders, obesity, and their effects on various biological processes, including hair growth and alopecia.

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Effective Amelioration of Hepatic Inflammation and Insulin Response in High-Fat Diet-Fed Rats via Regulating AKT/mTOR Signaling: Role of Lepidium Sativum Seed Extracts

research Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts

14 citations , October 2020 in “Journal of ethnopharmacology”

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

research Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages

6 citations , December 2022 in “Cell reports”

Eating a high-fat fish oil diet caused mice to lose hair due to a specific immune cell activity in the skin linked to a protein called E-FABP.

research AB1159 HIGH FAT DIET AND THE ADIPOCYTE TO MYOFIBROBLAST TRANSITION: IMPLICATIONS FOR SYSTEMIC SCLEROSIS CUTANEOUS FIBROSIS

June 2024

A high fat lard diet may protect against skin fibrosis and affect hair growth.

research The role of wood sterol in alopecia induced by high fat diet through lipid metabolism

May 2024 in “Food bioscience”

Wood sterol may help reduce hair loss caused by a high-fat diet.

research 930 High-fat diet exacerbates neutrophilic folliculitis by facilitating sequential chemokine expressions by keratinocytes and neutrophils

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

A high-fat diet worsens neutrophilic folliculitis by increasing certain chemokines.

research Downregulation of mRNAs Encoding Keratin-Associated Proteins in the Tongue of Mice Fed a High-Fat Diet

January 2024 in “Journal of Hard Tissue Biology”

A high-fat diet may weaken tongue structure by reducing certain protein genes.

research Impact of a High-Fat High-Carbohydrate (HFHC) Diet at a Young Age on Steroid Hormone Hair Concentrations in Mice: A Comparison with a Control Diet and Nutraceutical Supplementation

November 2025 in “Life”

A balanced diet is crucial for normalizing hormone levels and managing obesity-related issues.

Consumption of a Low-Carbohydrate and High-Fat Diet Exaggerates Biotin Deficiency in Mice

research Consumption of a low-carbohydrate and high-fat diet (the ketogenic diet) exaggerates biotin deficiency in mice

10 citations , September 2013 in “Nutrition”

The ketogenic diet can worsen biotin deficiency, suggesting a need for biotin supplements.

research Yangyin Qingre Huoxue Method in Traditional Chinese Medicine Ameliorates Atherosclerosis in ApoE^−/− Mice Suffering from High-Fat Diet and HSP65 Aggression

4 citations , January 2019 in “Evidence-based Complementary and Alternative Medicine”

Yangyin Qingre Huoxue Prescription may help treat atherosclerosis with fewer liver side effects than simvastatin.

research 477 Dietary fat- and obesity-sensitive dermal adipocyte PKCβ induction and inflammation cross-talk

April 2017 in “Journal of Investigative Dermatology”

Eating a lot of fat increases PKCβ and inflammation in skin fat cells, which affects skin and hair health.

Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

research Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

3 citations , September 2021 in “International Journal of Molecular Sciences”

Androgens and a high-fat diet may increase the risk of severe COVID-19 in women with PCOS by upregulating certain proteins in the heart and kidneys.

research Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity

April 2019 in “PLOS ONE”

A high-fat diet caused severe health problems in female macaques but was reversible with a normal diet, while male macaques reacted differently.

Polycystic Ovary Syndrome and Other Androgen Excess-Related Conditions: Can Changes in Dietary Intake Make a Difference?

research Polycystic Ovary Syndrome (PCOS) and Other Androgen Excess–Related Conditions: Can Changes in Dietary Intake Make a Difference?

48 citations , February 2008 in “Nutrition in Clinical Practice”

Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.

research Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota

1 citations , August 2022 in “Frontiers in Physiology”

Finasteride may help treat kidney disease caused by a high-fat diet by reducing harmful toxins and improving gut bacteria.

research Milestones in Photocarcinogenesis

29 citations , July 2013 in “Journal of Investigative Dermatology”

UV radiation causes skin cancer, but sunscreens and certain drugs can help prevent it.

research The Association of Polycystic Ovarian Syndrome Among Reproductive-Aged Women With Consumption of Junk Food in Jeddah, Saudi Arabia

November 2023 in “Curēus”

Eating junk food is linked to higher rates of PCOS and related symptoms in women.

research Role of Nutritional Diversity and Lifestyle in Polycystic Ovary Syndrome (PCOS) Risk among College Students: A Cross-Sectional Analysis of Mumbai Metropolitan Region, India

November 2025 in “Journal of Scientific Research and Reports”

Poor diet and frequent fast food increase PCOS risk.

research Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism

45 citations , August 2018 in “Journal of Lipid Research”

Blocking the ATX-LPA pathway may improve insulin sensitivity and mitochondrial function in obesity.

research Fatty acid composition of selected organs of gerbils maintained on a fat‐deficient or fat‐supplemented diet

4 citations , September 1977 in “Lipids”

Gerbils on a fat-deficient diet had altered fatty acid levels, hair loss, reduced sperm, and lower body weight.

research The Effects of the Ethanol Extract of Allium Ascalonicum L. in High-Fat-High-Fructose-Induced Insulin Resistance Swiss-Webster Male Mice

May 2025 in “Journal of Experimental Pharmacology”

Allium ascalonicum L. extract may help improve insulin resistance.

research Diagnosing Essential Fatty Acid Deficiency

18 citations , June 1998 in “Circulation”

Mild essential fatty acid deficiency can cause health issues and is worsened by low-fat diets.

research Skin as a mirror of metabolic syndrome: Do some dermatoses alarm internal metabolic sinister?

November 2024 in “IP Indian Journal of Clinical and Experimental Dermatology”

Certain skin conditions can indicate a higher risk of diabetes and heart problems.

research Rodent models in placental research. Implications for fetal origins of adult disease

7 citations , January 2022 in “Animal Reproduction”

Using rodents for research shows that health problems in the womb can cause diseases later in life.

research Clinical aspects of the metabolic syndrome

December 2017

Losing weight and eating better are key to managing metabolic syndrome and its related conditions.

research Relationship of Diet to Androgenetic Alopecia

1 citations , January 1996 in “Springer eBooks”

Diet affects baldness; eat balanced, less animal fat, more fruits, vegetables, and cereals.

research EFFECT OF OBESITY ON GENERAL HEALTH AND ON PAROTID SALIVARY GLANDS OF RATS- HISTOLOGICAL AND ULTRASTRUCTURAL STUDY

2 citations , April 2024 in “Alexandria Dental Journal”

A high-fat diet causes obesity, insulin resistance, poor health, and salivary gland damage.