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Did you mean High-Fat Diet?

GlossaryHigh-Fat Diet

diet high in fats, often over 35-40% of calories

A High-Fat Diet (HFD) is a dietary regimen where a significant portion of daily caloric intake comes from fats, often exceeding 35-40% of total calories. This type of diet is commonly used in research to study metabolic disorders, obesity, and their effects on various biological processes, including hair growth and alopecia.

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research Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages

6 citations , December 2022 in “Cell reports”

Eating a high-fat fish oil diet caused mice to lose hair due to a specific immune cell activity in the skin linked to a protein called E-FABP.

research AB1159 HIGH FAT DIET AND THE ADIPOCYTE TO MYOFIBROBLAST TRANSITION: IMPLICATIONS FOR SYSTEMIC SCLEROSIS CUTANEOUS FIBROSIS

June 2024

A high fat lard diet may protect against skin fibrosis and affect hair growth.

Effective Amelioration of Hepatic Inflammation and Insulin Response in High-Fat Diet-Fed Rats via Regulating AKT/mTOR Signaling: Role of Lepidium Sativum Seed Extracts

research Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts

14 citations , October 2020 in “Journal of ethnopharmacology”

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

research The role of wood sterol in alopecia induced by high fat diet through lipid metabolism

May 2024 in “Food bioscience”

Wood sterol may help reduce hair loss caused by a high-fat diet.

research 930 High-fat diet exacerbates neutrophilic folliculitis by facilitating sequential chemokine expressions by keratinocytes and neutrophils

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

A high-fat diet worsens neutrophilic folliculitis by increasing certain chemokines.

research Downregulation of mRNAs Encoding Keratin-Associated Proteins in the Tongue of Mice Fed a High-Fat Diet

January 2024 in “Journal of Hard Tissue Biology”

A high-fat diet may weaken tongue structure by reducing certain protein genes.

research Impact of a High-Fat High-Carbohydrate (HFHC) Diet at a Young Age on Steroid Hormone Hair Concentrations in Mice: A Comparison with a Control Diet and Nutraceutical Supplementation

November 2025 in “Life”

A balanced diet is crucial for normalizing hormone levels and managing obesity-related issues.

Consumption of a Low-Carbohydrate and High-Fat Diet Exaggerates Biotin Deficiency in Mice

research Consumption of a low-carbohydrate and high-fat diet (the ketogenic diet) exaggerates biotin deficiency in mice

10 citations , September 2013 in “Nutrition”

The ketogenic diet can worsen biotin deficiency, suggesting a need for biotin supplements.

research Yangyin Qingre Huoxue Method in Traditional Chinese Medicine Ameliorates Atherosclerosis in ApoE^−/− Mice Suffering from High-Fat Diet and HSP65 Aggression

4 citations , January 2019 in “Evidence-based Complementary and Alternative Medicine”

Yangyin Qingre Huoxue Prescription may help treat atherosclerosis with fewer liver side effects than simvastatin.

research Protective Effect of “ Ark‐e‐Kasni ,” a Unani Formulation, in Letrozole and High‐Fat Diet–Induced Polycystic Ovarian Syndrome in Rats

March 2026 in “Journal of obstetrics and gynaecology research”

Ark-e-Kasni improves PCOS symptoms and may be a potential treatment.

research 477 Dietary fat- and obesity-sensitive dermal adipocyte PKCβ induction and inflammation cross-talk

April 2017 in “Journal of Investigative Dermatology”

Eating a lot of fat increases PKCβ and inflammation in skin fat cells, which affects skin and hair health.

Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

research Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

3 citations , September 2021 in “International Journal of Molecular Sciences”

Androgens and a high-fat diet may increase the risk of severe COVID-19 in women with PCOS by upregulating certain proteins in the heart and kidneys.

research Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity

April 2019 in “PLOS ONE”

A high-fat diet caused severe health problems in female macaques but was reversible with a normal diet, while male macaques reacted differently.

Polycystic Ovary Syndrome and Other Androgen Excess-Related Conditions: Can Changes in Dietary Intake Make a Difference?

research Polycystic Ovary Syndrome (PCOS) and Other Androgen Excess–Related Conditions: Can Changes in Dietary Intake Make a Difference?

48 citations , February 2008 in “Nutrition in Clinical Practice”

Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.

research Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota

1 citations , August 2022 in “Frontiers in Physiology”

Finasteride may help treat kidney disease caused by a high-fat diet by reducing harmful toxins and improving gut bacteria.

research Milestones in Photocarcinogenesis

29 citations , July 2013 in “Journal of Investigative Dermatology”

UV radiation causes skin cancer, but sunscreens and certain drugs can help prevent it.

research Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease

9 citations , March 2022 in “Frontiers in Immunology”

Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.

research The Association of Polycystic Ovarian Syndrome Among Reproductive-Aged Women With Consumption of Junk Food in Jeddah, Saudi Arabia

November 2023 in “Curēus”

Eating junk food is linked to higher rates of PCOS and related symptoms in women.

research Clinical characteristics and factors associated with different BASP subtypes of androgenetic alopecia

May 2026 in “Frontiers in Medicine”

Androgenetic alopecia is linked to factors like age, family hair loss history, diet, and health conditions.

Alleviation of Hyperlipidemia, Insulin Resistance, and Myopathy by Nano Selenium/Nano CoQ10 Platform with Simvastatin in Hyperlipidemic Rats: Comprehensive Outlook

research Alleviation of hyperlipidemia, insulin resistance, and myopathy by nano selenium/ nano CoQ10 platform with simvastatin in hyperlipidemic rats; comprehensive outlook

January 2023 in “Research Square (Research Square)”

Nano selenium and CoQ10 helped reduce blood fat levels and insulin resistance while preventing muscle damage from statin drugs in rats.

research Role of Nutritional Diversity and Lifestyle in Polycystic Ovary Syndrome (PCOS) Risk among College Students: A Cross-Sectional Analysis of Mumbai Metropolitan Region, India

November 2025 in “Journal of Scientific Research and Reports”

Poor diet and frequent fast food increase PCOS risk.

research The effect of dietary change on in vitro erythrocyte haemolysis, skin lesions and alopecia in common marmosets (Callithrix jacchus)

7 citations , January 1991 in “Comparative biochemistry and physiology. A. Comparative physiology”

A diet high in vitamin E improved blood health, skin, and fur in common marmosets.

research Fatty acid composition of selected organs of gerbils maintained on a fat‐deficient or fat‐supplemented diet

4 citations , September 1977 in “Lipids”

Gerbils on a fat-deficient diet had altered fatty acid levels, hair loss, reduced sperm, and lower body weight.

The Effects of the Ethanol Extract of Allium Ascalonicum L. in High-Fat High-Fructose Induced Insulin Resistance in Swiss-Webster Male Mice

research The Effects of the Ethanol Extract of Allium Ascalonicum L. in High-Fat-High-Fructose-Induced Insulin Resistance Swiss-Webster Male Mice

May 2025 in “Journal of Experimental Pharmacology”

Allium ascalonicum L. extract may help improve insulin resistance.

research Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE−/− mice fed western diet

30 citations , July 2018 in “Scientific Reports”

Blocking certain fat production can reverse skin inflammation and hair loss.

research Diagnosing Essential Fatty Acid Deficiency

18 citations , June 1998 in “Circulation”

Mild essential fatty acid deficiency can cause health issues and is worsened by low-fat diets.

research Skin as a mirror of metabolic syndrome: Do some dermatoses alarm internal metabolic sinister?

November 2024 in “IP Indian Journal of Clinical and Experimental Dermatology”

Certain skin conditions can indicate a higher risk of diabetes and heart problems.

research Rodent models in placental research. Implications for fetal origins of adult disease

7 citations , January 2022 in “Animal Reproduction”

Using rodents for research shows that health problems in the womb can cause diseases later in life.

research Clinical aspects of the metabolic syndrome

December 2017

Losing weight and eating better are key to managing metabolic syndrome and its related conditions.

research Relationship of Diet to Androgenetic Alopecia

1 citations , January 1996 in “Springer eBooks”

Diet affects baldness; eat balanced, less animal fat, more fruits, vegetables, and cereals.