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GlossaryHippo pathway

signaling pathway controlling cell growth and organ size

The Hippo pathway is a signaling pathway in cells that controls organ size by regulating cell growth, division, and death. It plays a crucial role in tissue regeneration and stem cell function, and its dysregulation can lead to cancer and other diseases.

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research Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

7 citations , August 2022 in “Experimental dermatology”

Blocking YAP/TAZ could be a new way to treat skin cancer.

Inhibition of the Hippo Pathway by Verteporfin Reduces the Proliferation and Stemness of Rat Hair Follicle Neural Crest Stem Cells Under Hypoxia

research Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia

February 2025 in “FASEB BioAdvances”

Verteporfin reduces growth and stem cell traits in rat hair follicle cells by blocking the Hippo pathway.

research YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2

2 citations , January 2025 in “动物学研究”

YAP1 helps fat cell formation by influencing the Hippo pathway.

research CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation

3 citations , June 2025 in “Journal of Cellular and Molecular Medicine”

CuATSM speeds up wound healing and reduces scarring.

research Identification of key pathways and genes that regulate cashmere development in cashmere goats mediated by exogenous melatonin

3 citations , September 2022 in “Frontiers in veterinary science”

Melatonin affects cashmere growth in goats by influencing stem cell and certain signaling pathways.

research Co-opting Developmental Signaling Pathways to Promote Wound Healing

1 citations , January 2018 in “Recent clinical techniques, results, and research in wounds”

Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.

research YAP and TAZ are essential for basal and squamous cell carcinoma initiation

76 citations , June 2018 in “EMBO Reports”

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth

research A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth

30 citations , May 2018 in “Experimental Dermatology”

The conclusion is that future hair loss treatments should target the root causes of hair thinning, not just promote hair growth.

research YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate

14 citations , November 2024 in “International Journal of Molecular Sciences”

YAP and TAZ proteins control skin cell growth and repair.

research Multifunctional and immunoregulatory microenvironment-responsive hydrogel for whole course management of infected diabetic wounds

10 citations , August 2024 in “Chemical Engineering Journal”

The ATAN-Met hydrogel helps heal infected diabetic wounds by promoting tissue regeneration and fighting bacteria.

research Many Paths to Alopecia via Compromised Regeneration of Hair Follicle Stem Cells

8 citations , May 2013 in “Journal of Investigative Dermatology”

Different problems with hair stem cell renewal can lead to hair loss.

XMU-MP-1 Induces Growth Arrest in a Model Human Mini-Organ and Antagonizes Cell Cycle-Dependent Paclitaxel Cytotoxicity

research XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity

4 citations , September 2020 in “Cell division”

XMU-MP-1 stops cell growth in a human mini-organ and reduces the effectiveness of the chemotherapy drug paclitaxel.

research Computational derivation of a molecular framework for hair follicle biology from disease genes

4 citations , November 2017 in “Scientific Reports”

The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.

research The regenerative wound healing effects and molecular mechanism of Isaria cicadae Miquel rice fermentation extract

2 citations , February 2025 in “Applied Microbiology and Biotechnology”

Isaria cicadae Miquel rice fermentation extract helps heal wounds and regenerate hair follicles.

research Pu‐erh tea reduces the transmission of CRD‐mediated alopecia risk to offspring

1 citations , April 2024 in “Food Frontiers”

Pu-erh tea reduces hair loss risk in offspring.

Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

research Additional file 10 of Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus

January 2022 in “Figshare”

Melatonin affects specific gene patterns and biological processes in goat hair growth.

Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During The Cashmere Growth Cycle in Capra Hircus

October 2021 in “Research Square (Research Square)”

Melatonin affects certain genes and pathways involved in cashmere goat hair growth.

research Transcriptome Dynamics Reveal Stage-specific and Melatonin-triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

June 2021 in “Research Square (Research Square)”

Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.

research Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

24 citations , May 2022 in “BMC Veterinary Research”

lncRNAs play a key role in hair follicle development, affecting cashmere quality and yield.

research Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus

9 citations , February 2022 in “BMC Genomics”

Melatonin affects gene expression in goat hair follicles, potentially increasing cashmere production.

research Cutaneous transcriptome analysis in NIH hairless mice

7 citations , August 2017 in “PloS one”

Key genes linked to hair growth and cancer were identified in hairless mice.

research MiR-23b and miR-133 cotarget TGFβ2/NOTCH1 in dermal fibroblasts and affect hair follicle development in sheep

August 2023 in “Research Square (Research Square)”

Two microRNAs affect hair follicle development in sheep by targeting specific genes.

research Additional file 6 of Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus

January 2022 in “Figshare”

Melatonin affects different genes and pathways important for goat hair growth.

research 837 From genotoxic stresses to skin damage: Distinct, novel mechanisms of skin and hair damage in chemo/radiation therapy

April 2017 in “Journal of Investigative Dermatology”

Chemotherapy and radiation therapy cause skin and hair damage by altering gene expression and signaling pathways.

research Roles of Hippo signaling pathway in size control of organ regeneration

37 citations , April 2015 in “Development Growth & Differentiation”

The Hippo signaling pathway helps control organ size during regeneration by regulating gene expression.

research Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome

October 2023 in “Frontiers in endocrinology”

Effective PCOS treatments require targeting specific signaling pathways.

research GPCRs as key regulators in wound healing

April 2026 in “Frontiers in Cell and Developmental Biology”

GPCRs are vital for wound healing by affecting cell growth and immune response.

research 755 Repurposing of DPP4 inhibition to improve hair follicle activation and regeneration

July 2022 in “Journal of Investigative Dermatology”

Blocking DPP4 can help activate hair growth and improve hair regeneration.

research Comparative regenerative mechanisms across different mammalian tissues

252 citations , February 2018 in “npj Regenerative Medicine”

Understanding different species' regeneration can improve mammalian healing.

research Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration

37 citations , February 2024 in “Military Medical Research”

Biomaterials can help heal wounds without scars and regenerate skin features.