research Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals
Gut microbes significantly affect brain steroid levels.
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30-60 / 1000+ resultsresearch A Mouse Kindling Model of Perimenstrual Catamenial Epilepsy
Neurosteroids help reduce seizures, but their withdrawal increases seizure activity.
research Investigation of the crosstalk between proteasome function and nucleotide excision repair mechanism during ageing
The document concludes that the discussed biological mechanisms and potential therapies are not related to hair loss or hair growth.
research Neurosteroids, neuroactive steroids, and symptoms of affective disorders
Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.
research Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration
Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.
research Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men
Finasteride can cause sexual problems and depression in young men.
research Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain
Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.
research The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats
Finasteride helps protect brain in old male rats.
research Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth
Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.
research Fetal Alcohol Syndrome: Current Status of Pathogenesis
The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.
research 5α-Reduced glucocorticoids: a story of natural selection
Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
research Effect of neurosteroid dehydroepiandrosterone on the higher nervous activity of old non-human primates
DHEA improved brain function and behavior in old monkeys and had additional health benefits.
research Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model
A natural steroid in the body may protect against eye damage in glaucoma.
research Preclinical Evidence and Underlying Mechanisms of Polygonum multiflorum and Its Chemical Constituents Against Cognitive Impairments and Alzheimer’s Disease
Polygonum multiflorum shows promise for treating Alzheimer's and cognitive impairments.
research The potential involvement of cholinergic system in finasteride induced cognitive dysfunction
Finasteride might affect memory by impacting cholinergic system.
research A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) L.
Eclipta prostrata has many traditional uses and health benefits, but more research is needed to understand how it works and ensure it's safe.
research Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain
Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.
research Therapeutic Potential of Nerve Growth Factor-Modified Hair Follicle Stem Cells Transplantation in a Rat Model of Alzheimer’s Disease
NGF-modified hair follicle stem cells may help treat Alzheimer's by improving brain function and reducing harmful proteins.
research Transcriptome profiling of whisker follicles in methamphetamine self-administered rats
Methamphetamine affects gene expression in rat whisker follicles, with key genes linked to addiction.
research Post-finasteride syndrome – does it really exist?
Post-finasteride syndrome's existence is uncertain; more research needed.
research Biological effects of human placental extracts - variations in manufacturing methods and compositions
Placental extracts have antioxidant, anti-inflammatory, and immune-boosting effects, but their exact workings are unclear.
research WNT Signaling in Disease
The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.
research Midazolam Ameliorates the Behavior Deficits of a Rat Posttraumatic Stress Disorder Model through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis
Midazolam reduces PTSD-like behavior in rats by acting on specific brain receptors.
research Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies
Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.
research The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites
Juniperus plants contain compounds with potential for developing various medical treatments.
research Avaliação de respostas defensivas associadas ao pânico em ratas: perfil da ativação serotonérgica no núcleo dorsal da rafe e substância cinzenta periaquedutal
Female rats showed more panic-related behavior than males, influenced by hormonal cycles and certain drugs.
research Physiologic functions of PP2A: Lessons from genetically modified mice
Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.
research Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report
Finasteride use may lead to less alcohol consumption in men with lasting sexual side effects.
research Roles of steroid sulfatase in brain and other tissues
Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.
research Mechanisms underlying select chemotherapeutic-agent-induced neuroinflammation and subsequent neurodegeneration
Chemotherapy can cause brain inflammation and damage, and understanding this process could help manage side effects.