research Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update
Botulinum and tetanus neurotoxins are better understood now, with updated information on their effects and treatment.
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300-330 / 1000+ results research Nigella sativa and its nano‐mediated approach toward management of neurodegenerative disorders: A review
Black cumin and its nanoformulations show promise in treating neurodegenerative diseases.
research Organizational Effects of Estrogens and Androgens on Estrogen and Androgen Receptor Expression in Pituitary and Adrenal Glands in Adult Male and Female Rats
Early hormones shape sex-specific differences in rat glands.
research Mitochondrial dysfunction in an animal model of diabetic neuropathy is associated with a reduction of neurosteroid synthesis.
Diabetic neuropathy in mice is linked to poor mitochondria function and lower brain hormone production.
research Role of BK channels and Kv4.2 channels in the electrophysiological properties of Merkel cells in rat whisker hair follicles
BK and Kv4.2 channels help Merkel cells in rat whiskers sense touch.
research Nucleus‐specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus
Brain-made chemicals can control nerve cell function differently in various parts of a mouse's brain, which may help us understand neurological conditions.
research GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects
GLP-1 receptor agonists, like Dulaglutide, Liraglutide, and Semaglutide, have potential benefits beyond the pancreas, including neuroprotection, pain suppression, cardiovascular protection, obesity management, and cancer treatment, but there are concerns about pancreatitis and pancreatic cancer risks.
research Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats
Allopregnanolone affects fear responses differently in male and female rats, possibly explaining sex differences in anxiety disorders.
research Role of neurosteroids in the anticonvulsant activity of midazolam
Midazolam's seizure prevention is partly due to increased neurosteroid production.
research Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases
H1 increases risk for neurodegenerative diseases, while H2 offers protection but is linked to other disorders.
research KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors
KCNQ potassium channels help control the sensitivity of touch receptors in the skin.
research Toll-like receptor 4 (TLR4): new insight immune and aging
TLR4 is important in aging-related diseases and could be a new treatment target.
research Linking the brain and bone through fat
Fat, bone, and the brain are interconnected in regulating energy and health.
research Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review
Tremella fuciformis polysaccharide has many health benefits and potential uses in food, medicine, and cosmetics.
research Mitochondrial dysfunction in diabetic neuropathy may be involved in the development of neuropathic pain via a reduction in neurosteroid synthesis
Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.
research Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases
Long-lived proteins may predict age-related diseases.
research Pharmacological and Biological Efficacy of Chitosan-Based Materials
Chitosan-based materials are promising for treating diseases and healing wounds due to their beneficial properties.
research Forsythiasides: A review of the pharmacological effects
Forsythiasides have multiple health benefits but may cause pseudoallergic reactions, and more research is needed.
research The emerging role of cellular senescence in amyotrophic lateral sclerosis
Cellular senescence may play a role in ALS, and anti-senescence therapies could be a promising treatment.
research Depressive and Anxiety Symptoms in Women with Polycystic Ovary Syndrome: A Meta-Analysis
Women with PCOS are more likely to experience depressive symptoms.
research Pregnancy's lasting imprint: Late pregnancy allopregnanolone alters rat fear recall and medial prefrontal cortex activity
Pregnancy affects fear memory and brain activity in female rats.
research Histopathological change of age-related hearing loss in female advance-aged CBA/CaJ mice
Age-related hearing loss involves cochlear damage and metabolic changes.
research Depression, higher level of tension induction, and impaired coping strategies in response to stress in women with PCOS correlate with clinical and laboratory indices of hyperandrogenism and not with central obesity and insulin resistance
Women with PCOS have more depression and stress due to high androgen levels, not obesity or insulin resistance.
research Sex Differences in Opioid-Mediated Effects: Role of Androgens
Men and women react differently to opioids, with hormones potentially influencing these differences.
research Exploring the possibility of predicting human head hair greying from DNA using whole-exome and targeted NGS data
Hair greying is mainly influenced by age, with genetics playing a smaller role.
research Neurological post‐acute sequelae of SARS‐CoV ‐2 infection
Long COVID affects over half of COVID-19 survivors, causing a range of symptoms like fatigue and neurological issues, with no specific treatment yet.
research Regulation of stem cell fate by HSPGs: implication in hair follicle cycling
HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.
research Three-Dimensional Analysis of Sex- and Gonadal Status- Dependent Microglial Activation in a Mouse Model of Parkinson’s Disease
Sex and sex hormones can affect brain inflammation in Parkinson's disease, with male mice being more affected and female mice showing a protective effect.
research Food and medicine homology: a potential nutritional intervention strategy for post-acute COVID-19 syndrome
FMH foods may help manage post-acute COVID-19 symptoms safely and easily.
research Hair Zinc and Chromium Levels Were Associated with a Reduced Likelihood of Age Related Cognitive Decline in Centenarians and Oldest-Old Adults
Higher hair levels of zinc and chromium were linked to less cognitive decline in very old people.