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research Hair-specific expression of chloramphenicol acetyltransferase in transgenic mice under the control of an ultra-high-sulfur keratin promoter.

33 citations , September 1990 in “Proceedings of the National Academy of Sciences”

The study showed that a specific DNA sequence can control gene expression in hair growth areas of mice.

research The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes

56 citations , September 2014 in “Molecular Endocrinology”

Vitamin D receptor is essential for hair growth signaling.

research Role of Csdc2 in Regulating Secondary Hair Follicle Growth in Cashmere Goats

2 citations , July 2024 in “International Journal of Molecular Sciences”

Csdc2 helps hair growth in cashmere goats by regulating specific genes.

research NEW NON SYNTHETIC MOLECULES ARE ABLE TO INHIBIT APOPTOSIS IN DERMAL PAPILLAR CELLS OF HAIR BULB

January 2011 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)”

New molecules can prevent cell death in hair follicles.

research Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21

37 citations , January 1993 in “Journal of Investigative Dermatology”

research Glycyrrhizic acid attenuates stem cell-like phenotypes of human dermal papilla cells

21 citations , November 2015 in “Phytomedicine”

Glycyrrhizic acid may help reduce unwanted hair growth.

Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

research Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets

3 citations , May 2022 in “Experimental Dermatology”

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.

research Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity

December 2022 in “Biochemical and Biophysical Research Communications”

HtrA2 activity is crucial for normal hair growth by regulating fat cell development.

Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

research Smad1 and 5 but Not Smad8 Establish Stem Cell Quiescence Which Is Critical to Transform the Premature Hair Follicle During Morphogenesis Toward the Postnatal State

31 citations , September 2013 in “Stem Cells”

Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.

research The polygenic architecture of hidradenitis suppurativa reveals signaling mechanisms that implicate epithelial remodeling

July 2025

Blocking CXCR4 may help treat hidradenitis suppurativa.

research SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

87 citations , September 2019 in “Nature Communications”

SOX11 and SOX4 help skin cells act like embryonic cells to heal wounds in mice.

research Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation

1 citations , April 2022 in “Cell Death Discovery”

Increasing Smurf2 hinders hair follicle stem cell differentiation and wound healing.

research A Missense Mutation in the Cadherin Interaction Site of The Desmoglein 4 Gene Underlies Localized Autosomal Recessive Hypotrichosis

33 citations , October 2005 in “Journal of Investigative Dermatology”

A specific gene mutation causes sparse, brittle hair in a family.

research Hypohidrotic Ectodermal Dysplasia with c.28delG Mutation in Ectodysplasin A Gene and Severe Atopic Dermatitis Treated Successfully with Tofacitinib

4 citations , November 2020 in “Acta Dermato Venereologica”

Tofacitinib effectively improved severe skin symptoms in a patient with Hypohidrotic Ectodermal Dysplasia.

research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations , May 2013 in “PloS one”

The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.

research Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages

71 citations , June 2005 in “Journal of Investigative Dermatology”

PAD enzymes play a key role in hair growth and structure.

research The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice

73 citations , May 2009 in “Proceedings of the National Academy of Sciences”

Disrupting the Sox21 gene in mice causes hair loss and regrowth cycles.

research Role of vitamin D receptor in the epidermal function and hair follicle homeostasis.

November 2016 in “The Molecular Biology Society of Japan”

research Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells

31 citations , October 2010 in “BMB Reports”

L-threonate may help prevent balding by blocking a key protein.

research The role of hsa‐miR‐193a‐5p as an important factor for control of inositol in alopecia areata

June 2024 in “Skin Research and Technology”

hsa-miR-193a-5p may help diagnose and treat alopecia areata.

research Downregulation of nuclear factor-kappaB activation in human keratinocytes by melanogenesis inhibitors

May 2004 in “International Journal of Cosmetic Science”

Melanogenesis inhibitors like kojic acid and niacinamide can reduce inflammation and pigment production in skin cells.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

17 citations , March 2012 in “Journal of biological chemistry/The Journal of biological chemistry”

Hairless protein affects hair follicle structure by regulating the Dlx3 gene.

research Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin

124 citations , November 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

PAD3 plays a key role in hair and skin protein structure and may be linked to skin diseases.

research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

54 citations , February 2002 in “Carcinogenesis”

Increasing SSAT makes skin more prone to cancer.

Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin

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