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December 2000 in “Experimental Dermatology” Involucrin is a useful marker for keratinocyte differentiation in mice.
September 2017 in “Journal of Investigative Dermatology” Ceramide may help delay hair aging by restoring stressed hair cells.
86 citations
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October 2017 in “Clinics in Dermatology” Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.
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May 2001 in “Development” Overexpression of Hoxc13 in hair cells causes hair loss and skin issues.
1 citations
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July 2021 in “IntechOpen eBooks” Environmental factors can cause mutations in skin proteins, leading to skin disorders.
June 2026 in “Communications Biology” Hoxc13 and hair keratin are needed for forming rough skin on frog mating pads.
86 citations
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June 1998 in “Journal of Investigative Dermatology” The hairless gene mutation causes baldness by disrupting hair follicle structure.
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May 2016 in “Experimental Dermatology” The type of tumor suppressor gene lost affects the behavior of skin cancer.
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July 2004 in “Journal of Investigative Dermatology” Certain tyrosine kinases may regulate hair growth and could help develop hair loss treatments.
November 2022 in “Journal of Investigative Dermatology” Skin aging and cancer development are influenced by the competition between stem cells.
143 citations
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May 2007 in “Proceedings of the National Academy of Sciences” Vitamin D receptor is crucial for normal hair growth and preventing hair loss.
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May 2002 in “The American journal of pathology” Cathepsin L is essential for normal hair growth and development.
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September 2004 in “Journal of Biological Chemistry” Hoxc13 regulates specific hair protein genes on mouse chromosome 16.
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August 1980 in “Journal of Cutaneous Pathology” Rhodamin B stain is inconsistent for keratin in skin samples.
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June 2012 in “PLOS ONE” KLF4 is important for maintaining skin stem cells and helps heal wounds.
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March 1994 in “PubMed” High ODC and low K1 and K10 may indicate early skin tumors in mice.
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December 2013 in “Stem cells and development” Horse skin stem cells combined with platelet-rich plasma improve skin healing.
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February 2025 in “Frontiers in Medicine” IGF-1, KGF, and stem cells help skin cells move and survive, potentially speeding up wound healing.
February 2025 in “Animals” Understanding proteins in skin structures like claws and hair is crucial for future research.
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August 2014 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine” Human hair keratin can be used in many medical applications.
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March 2021 in “Molecular Carcinogenesis” Twist1 is crucial for UVB-induced skin cancer development.
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September 1994 in “Journal of Medical Genetics” Pachyonychia congenita is linked to a keratin gene on chromosome 17.
April 2023 in “Cancer research” KRTAP2-3 could help predict cancer recurrence by identifying specific cancer cells.
Hair follicle stem cells are crucial for touch sensation and proper nerve structure in mice.
November 2023 in “Journal of Investigative Dermatology” Removing GRK2 in skin cells causes hair loss similar to immune-related alopecia.
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August 2007 in “Annals of Anatomy - Anatomischer Anzeiger” Feathers become harder as they develop due to a change in keratin type.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The Kras mutation changes normal cell signals, leading to disrupted tissue structure and potential cancer.
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January 2009 in “Advances in Materials Science and Engineering” Wool keratin is reactive, biocompatible, biodegradable, and can model keratin from other sources.
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November 2013 in “Development” Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.
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July 2001 in “PubMed” A new type of pachyonychia congenita may exist, caused by a different keratin mutation.