135 citations
,
November 1987 in “Differentiation” Outer root sheath cells consistently express certain keratins influenced by their environment.
126 citations
,
January 1987 in “Current topics in developmental biology/Current Topics in Developmental Biology” Different keratin proteins are expressed in various epithelial cells at different stages, affecting cell structure and function.
98 citations
,
June 2001 in “Journal of biological chemistry/The Journal of biological chemistry” A cluster of sulfur-rich hair protein genes was found on chromosome 17.
44 citations
,
May 1997 in “Journal of Biological Chemistry” The human keratin 6a gene's specific sequences trigger expression in skin layers after injury.
21 citations
,
January 1995 in “Molecular Biology Reports” Scientists discovered two versions of a new human hair keratin gene.
6 citations
,
February 2013 in “British Journal of Dermatology” Androgens significantly regulate hair keratin K37 expression.
August 2024 in “Advanced Healthcare Materials” RK81 can help promote hair growth.
17 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Mutations in hKAP1 genes may cause hereditary hair disorders.
69 citations
,
October 2013 in “Tissue Engineering Part A” Keratin hydrogel improves nerve regeneration and motor recovery.
2 citations
,
September 2013 in “日本香粧品学会誌” Keratin films can measure hair heat damage.
January 2006 in “Basic & Clinical Medicine” Hair keratin doesn't significantly affect rat organ function but may help detect early rejection through blood changes.
2 citations
,
April 2008 in “PubMed” A gene mutation causes monilethrix in a Chinese family.
277 citations
,
October 1982 in “The Journal of Cell Biology” Basal-cell epitheliomas and the pilosebaceous tract share a unique keratin, distinguishing them from other skin areas.
66 citations
,
February 2013 in “PeerJ” Activating cannabinoid receptor 1 reduces certain keratin levels, potentially aiding psoriasis treatment.
40 citations
,
September 2010 in “Journal of Biological Chemistry” Keratin K80 is an ancient protein found in various tissues, important for cell structure and tissue differentiation.
27 citations
,
June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” The study found that variations in hair protein genes are likely due to evolutionary deletions or duplications.
4 citations
,
December 1995 in “Anthropologischer Anzeiger” Family members have similar hair protein patterns, which could be useful for genetic studies.
74 citations
,
October 1998 in “Journal of biological chemistry/The Journal of biological chemistry” The 190-kbp domain contains all human type I hair keratin genes, showing their organization and evolution.
51 citations
,
January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.
2 citations
,
September 2020 in “Biomedical materials” Recombinant keratin materials may better promote skin cell differentiation than natural keratin.
1 citations
,
June 2014 in “[Thesis]. Manchester, UK: The University of Manchester; 2014.” Chemical modifications can alter hair's stability and flexibility, with hydrophobic interactions helping maintain structure in humid conditions.
132 citations
,
February 2002 in “Journal of Biological Chemistry” HOXC13 is crucial for regulating hair keratin genes in hair follicles.
48 citations
,
November 2002 in “Journal of biological chemistry/The Journal of biological chemistry” Genetic variations in hair keratin proteins exist but don't significantly affect hair structure.
35 citations
,
October 2002 in “Biochemical and Biophysical Research Communications” The research cloned keratin 7 genes from humans, mice, and marsupials, found similarities between human and mouse genes, and discovered new areas of K7 expression in mice.
22 citations
,
January 2020 in “PeerJ” Keratin peptides in hair might help identify gender and ethnicity.
11 citations
,
May 2013 in “Journal of Investigative Dermatology” KRTAP10 proteins help form the hair shaft's tough outer layer by interacting with specific hair keratins.
1 citations
,
January 1989 in “Springer eBooks” 25 citations
,
September 1995 in “Biochemistry and Cell Biology” High levels of human keratin 16 in mice cause skin lesions and abnormal skin development.
49 citations
,
April 2010 in “International Journal of Cosmetic Science” Hair ages as the cuticle wears down, especially beyond 1 meter from the root, affecting its strength and shine.
3 citations
,
January 2015 in “Sen i Gakkaishi” The new keratin film without KAPs stains better and could help study keratin functions.